scholarly journals Evaluation of Functional Recovery in Rats After Median Nerve Resection and Autograft Repair Using Computerized Gait Analysis

2021 ◽  
Vol 14 ◽  
Author(s):  
Johannes C. Heinzel ◽  
Viola Oberhauser ◽  
Claudia Keibl ◽  
Nicole Swiadek ◽  
Gregor Längle ◽  
...  
Keyword(s):  
Gait Analysis ◽  
Nerve Regeneration ◽  
Median Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Duty Cycle ◽  
Evaluation Method ◽  
Additional Tool ◽  
The Right ◽  
Median Nerve Injury

Computerized gait analysis is a common evaluation method in rat models of hind limb nerve injuries, but its use remains unpublished in models of segmental nerve injury of the forelimb. It was the aim of this work to investigate if computerized gait analysis is a feasible evaluation method in a rat model of segmental median nerve injury and autograft repair. Ten male Lewis rats underwent 7-mm resection of the right median nerve with immediate autograft repair. The left median nerve was resected without repair and served as an internal control. Animals were assessed for 12 weeks after surgery via CatWalk (CW) gait analysis every 2 weeks. Evaluation of motor recovery by means of the grasping test was performed weekly while electrophysiological measurements were performed at the end of the observation period. CW data were correlated with grasping strength at each post-operative time point. CW data were also correlated with electrophysiology using linear regression analysis. Principal component analysis was performed to identify clusters of outcome metrics. Recovery of motor function was observable 4 weeks after surgery, but grasping strength was significantly reduced (p < 0.01) compared to baseline values until post-operative week 6. In terms of sensory recovery, the pain-related parameter Duty Cycle showed significant (p < 0.05) recovery starting from post-operative week 8. The Print Area of the right paw was significantly (p < 0.05) increased compared to the left side starting from post-operative week 10. Various parameters of gait correlated significantly (p < 0.05) with mean and maximum grasping strength. However, only Stand Index showed a significant correlation with compound muscle action potential (CMAP) amplitude (p < 0.05). With this work, we prove that computerized gait analysis is a valid and feasible method to evaluate functional recovery after autograft repair of the rat median nerve. We were able to identify parameters such as Print Area, Duty Cycle, and Stand Index, which allow assessment of nerve regeneration. The course of these parameters following nerve resection without repair was also assessed. Additionally, external paw rotation was identified as a valid parameter to evaluate motor reinnervation. In summary, computerized gait analysis is a valuable additional tool to study nerve regeneration in rats with median nerve injury.

scholarly journals Surgical outcome of prognostic factors for final outcome of hand function following primary median nerve repair

2018 ◽  
Vol 5 (11) ◽  
pp. 3672
Author(s):  
S. Dhanaraju ◽  
N. Kannan
Keyword(s):  
Prognostic Factors ◽  
Median Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Nerve Repair ◽  
Hand Function ◽  
Tendon Injury ◽  
Final Outcome ◽  
Nerve Injuries ◽  
Median Nerve Injury

Background: A major problem in surgery of median nerve injuries is the unpredictable final outcome, so identifying the prognostic factors for final outcome is needed in primary median nerve repair following injury. Assessing the functional recovery of hand function following median nerve repair.Methods: Total no. of patients with median nerve injury repaired in our institution was 70. All the patients assessed preoperatively by clinical examination, surgery performed immediately or within 12 hours of injury, performed under axillary block and tourniquet control, Multiple surgeons involved (about 6 surgeons). All are primarily repaired nerves, repair by 70 prolene epineural sutures, postoperative immobilization of 3 weeks.Results: Median nerve injury associated with other flexors involved patients show good functional recovery, the functional recovery deteriorate once involvement of finger flexors, particularly if all the tendons were injured. The arterial injury and repair don’t seem to influence the outcome of the hand function, but both artery involvement usually associated with all tendon injury, it shows poor outcome.Conclusions: The more distal the injury the outcome will be quicker as compared to middle 1/3 and proximal 1/3 injuries. Pure median nerve injuries sensory recovery in S4 grade about 5%, S3+ recovery of sensation is about 36%. Pure median nerve injury patients M4 motor recovery about 54%.Only median nerve injury the final outcome is good but combined median and ulnar nerve injury and associated tendon injury the outcome is poor. 

scholarly journals Pseudoaneurysm with Median Nerve Injury Caused by Right Radial Artery Puncture: A Case Report

2020 ◽  
Author(s):  
Zengmig Xue
Keyword(s):  
Median Nerve ◽  
Nerve Injury ◽  
Radial Artery ◽  
Severe Pain ◽  
Index Finger ◽  
Chest Tightness ◽  
Treatment Measures ◽  
The Right ◽  
Median Nerve Injury

Background: Pseudoaneurysm with median nerve injury is a serious complication of radial artery puncture. It is very important to summarize the prevention and treatment experience of this complication through case discussion.Case report: A 66-year-old woman was admitted to the hospital because of ‘‘paroxysmal chest tightness and suffocationfor 5 days.” Coronary angiography was performed. During insertion of the arterial sheath, the patient experiencedsevere pain in the right forearm, which radiated to the palm. The puncture sheath did not return blood after the sheathcore was withdrawn. The sheath was removed and local compression was used to stop bleeding. There was no obvious bleeding at the puncture point, and the compression was removed 6 hours after the procedure. Local swelling and increased tension were seen in the right forearm. At the 1-week follow-up she exhibited swelling, high local tension, small blisters, and bluish-purple skin of the right forearm, with an acceptable right radial artery pulsation. She had severe pain in the affected limb, which radiated to the thumb, index finger, and middle finger.Case discussion: We discuss the causes of and treatment measures for pseudoaneurysm with median nerve injury caused by radial artery puncture.

Use of the CatWalk gait analysis system to assess functional recovery in rodent models of peripheral nerve injury – a systematic review

2020 ◽  
Vol 345 ◽  
pp. 108889
Author(s):  
Johannes Heinzel ◽  
Gregor Längle ◽  
Viola Oberhauser ◽  
Thomas Hausner ◽  
Jonas Kolbenschlag ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Nerve ◽  
Gait Analysis ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Rodent Models ◽  
Analysis System

Acute Median Nerve Injury due to Migration of a Kirschner Wire

1998 ◽  
Vol 23 (1) ◽  
pp. 112-113 ◽  
Author(s):  
I-M. JOU ◽  
K-A. LAI
Keyword(s):  
Median Nerve ◽  
Nerve Injury ◽  
Kirschner Wire ◽  
Orthopaedic Implants ◽  
K Wires ◽  
Median Nerve Injury

Migration of orthopaedic implants such as K-wires is not unusual, but migration due to an improperly constructed brace has not been reported. This report describes such a mechanism in a case complicated by acute median nerve injury.

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