Past smoking and current dopamine agonist use show an independent and dose-dependent association with impulse control disorders in Parkinson's disease

2013 ◽  
Vol 19 (7) ◽  
pp. 698-700 ◽  
Author(s):  
Guilherme T. Valença ◽  
Philip G. Glass ◽  
Nadja N. Negreiros ◽  
Meirelayne B. Duarte ◽  
Lais M.G.B. Ventura ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Agonist ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
Dose Dependent

scholarly journals Impulse Control Disorders in Parkinson’s Disease: From Bench to Bedside

2021 ◽  
Vol 15 ◽  
Author(s):  
Andrea Augustine ◽  
Catharine A. Winstanley ◽  
Vaishnav Krishnan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Agonist ◽  
Impulse Control ◽  
Neurodegenerative Disorder ◽  
Impulse Control Disorders ◽  
Special Focus ◽  
Motor Impairments ◽  
Dopamine Agonist Therapy ◽  
Compulsive Behaviors

Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by symptoms that impact both motor and non-motor domains. Outside of motor impairments, PD patients are at risk for impulse control disorders (ICDs), which include excessively disabling impulsive and compulsive behaviors. ICD symptoms in PD (PD + ICD) can be broadly conceptualized as a synergistic interaction between dopamine agonist therapy and the many molecular and circuit-level changes intrinsic to PD. Aside from discontinuing dopamine agonist treatment, there remains a lack of consensus on how to best address ICD symptoms in PD. In this review, we explore recent advances in the molecular and neuroanatomical mechanisms underlying ICD symptoms in PD by summarizing a rapidly accumulating body of clinical and preclinical studies, with a special focus on the utility of rodent models in gaining new insights into the neurochemical basis of PD + ICD. We also discuss the relevance of these findings to the broader problem of impulsive and compulsive behaviors that impact a range of neuropsychiatric syndromes.

scholarly journals Risky decision-making and affective features of impulse control disorders in Parkinson’s disease

2017 ◽  
Vol 125 (2) ◽  
pp. 131-143 ◽  
Author(s):  
Alice Martini ◽  
Simon J. Ellis ◽  
James A. Grange ◽  
Stefano Tamburin ◽  
Denise Dal Lago ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
Risky Decision Making ◽  
Risky Decision

P.5.d.005 Reduced dopamine transporter binding predates impulse control disorders in Parkinson's disease

2013 ◽  
Vol 23 ◽  
pp. S548-S549
Author(s):  
O.A. Van den Heuvel ◽  
C. Vriend ◽  
A.H. Nordbeck ◽  
J. Booij ◽  
Y.D. Van der Werf ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Transporter ◽  
Impulse Control ◽  
Impulse Control Disorders

scholarly journals Clinical and psychopathological factors associated with impulse control disorders in Parkinson's disease

2016 ◽  
Vol 31 (4) ◽  
pp. 231-238 ◽  
Author(s):  
N. Sáez-Francàs ◽  
G. Martí Andrés ◽  
N. Ramírez ◽  
O. de Fàbregues ◽  
J. Álvarez-Sabín ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
Factors Associated

scholarly journals Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies

2021 ◽  
Vol 12 ◽  
Author(s):  
Jun-Fang Zhang ◽  
Xi-Xi Wang ◽  
Ya Feng ◽  
Robert Fekete ◽  
Joseph Jankovic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Broad Spectrum ◽  
Impulse Control ◽  
Compulsive Buying ◽  
Therapeutic Strategies ◽  
Impulse Control Disorders ◽  
Dopaminergic Therapy ◽  
Disease Epidemiology ◽  
Tremendous Impact

Impulse control disorders (ICDs) in Parkinson's disease (PD) are aberrant behavior such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically occur as a result of dopaminergic therapy. Numerous studies have focused on the broad spectrum of ICDs-related behaviors and their tremendous impact on patients and their family members. Recent advances have improved our understanding of ICDs. In this review, we discuss the epidemiology, pathogenesis and treatment of ICDs in the setting of PD.

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