scholarly journals Grade G2 Rectal Neuroendocrine Tumor Is Much More Invasive Compared With G1 Tumor

2021 ◽  
Vol 11 ◽  
Author(s):  
Yi-Wei Li ◽  
Yi-Ping He ◽  
Fang-Qi Liu ◽  
Jun-Jie Peng ◽  
San-Jun Cai ◽  
...  

BackgroundTo compare clinicopathologic feature of rectal neuroendocrine tumor (NET) grade G1 with G2 NET.MethodsSix hundred-one cases of rectal G1 and G2 NETs diagnosed in our center were analyzed.ResultsOf 601 cases of rectal NET, 515 cases were with grade G1 and 86 cases were with grade G2. Median tumor size was 0.7 cm. Compared with G1 NET, G2 tumors were with significantly larger tumor size (0.8 vs 2.2 cm, p < 0.001), less percentages of patients with tumors confined to submucosa (92.6 vs 42.8%, p < 0.001), more frequent presence of microvascular invasion (MVI) (3.6 vs 16.9%, p < 0.001) or peri-neural invasion (PNI) (2.0 vs 24.1%, p < 0.001). Incidence of lymph node and distant metastasis was 5.2 and 2.1% in G1 NET compared with 44.2 and 31.4% in G2 tumor, respectively (p < 0.001). For tumors sized 1–2 cm and confined to submucosa, incidence of lymph node metastasis was 6.1% for G1 NET compared with 21.1% for G2 NET. Status of MVI/PNI was predictive of lymph node metastasis for G2 tumor rather than G1 NET in this subgroup.ConclusionsRectal G2 NET was much more invasive with significantly elevated prevalence of lymph node metastasis compared with G1 tumor.

Author(s):  
Akira Sakamoto ◽  
Hiroaki Nozawa ◽  
Hirofumi Sonoda ◽  
Munetoshi Hinata ◽  
Hiroaki Ishii ◽  
...  

2017 ◽  
Vol 91 (1) ◽  
pp. 178-179
Author(s):  
Takashi Ogimi ◽  
Hideo Shimada ◽  
Takayuki Nishi ◽  
Takayuki Tajima ◽  
Hiroshi Miyakita ◽  
...  

2019 ◽  
Vol 80 (7) ◽  
pp. 1341-1346
Author(s):  
Masashi NAKAGAWA ◽  
Jun KAWACHI ◽  
Rai SHIMOYAMA ◽  
Naoko ISOGAI ◽  
Hiroyuki KASHIWAGI ◽  
...  

2016 ◽  
Vol 49 (6) ◽  
pp. 556-562 ◽  
Author(s):  
Shinichi Umeda ◽  
Mitsuhiro Hishida ◽  
Satomi Jinno ◽  
Minoru Shimizu ◽  
Hiroyuki Kobayashi ◽  
...  

2016 ◽  
pp. 56-60
Author(s):  
Van Minh Nguyen ◽  
Hong Loi Nguyen ◽  
Thi Kim Anh Dang

Background: To evaluate the clinical, hystopathologycal features and correlation between lymph node metastasis and hystopathologycal grade in patients with carcinoma of the oral cavity. Materials and Methods: From July 2015 to July 2016, 32 patients with carcinoma of the oral cavity at Hue Central Hospital Results: The most common age group from 51 to 60 years and the male/female ratio was 1.9/1. Tumor were usually observed around the the tongue (40.6%) and oral floor (34.4%). Most of the tumor size is larger than 2 cm diameters (> 80%). The regional lymph node metastasis rate was 43.8% and there was a positive correlation between lymph node metastasis and tumor size (p <0.05). Squamous-cell carcinoma was mainly type of histopathology. Difference between the rate of lymph node metastasis in patient groups with different histopathological grade show no statistical significance (p> 0.05). Conclusion: the greater tumor, the higher regional lymph node metastasis. There is no relationship between the lymph node metastasis rate and histopathological grade of oral carcinoma. Key words: : carcinoma of oral cavity, tumor size, lymph node metastasis, histopathology


2021 ◽  
Vol 28 (3) ◽  
pp. 1663-1672
Author(s):  
Satomi Hattori ◽  
Nobuhisa Yoshikawa ◽  
Kazumasa Mogi ◽  
Kosuke Yoshida ◽  
Masato Yoshihara ◽  
...  

(1) This study investigated the prognostic impact of tumor size in patients with metastatic cervical cancer. (2) Methods: Seventy-three cervical cancer patients in our institute were stratified into two groups based on distant metastasis: para-aortic lymph node metastasis alone (IIIC2) or spread to distant visceral organs with or without para-aortic lymph node metastasis (IVB) to identify primary tumor size and concurrent chemoradiotherapy. (3) Results: The overall survival (OS) for patients with a tumor >6.9 cm in size was significantly poorer than that for patients with a tumor ≤6.9 cm in the IVB group (p = 0.0028); the corresponding five-year OS rates in patients with a tumor ≤6.9 and >6.9 cm were 53.3% and 13.4%, respectively. In the multivariate analysis, tumor size and primary treatment were significantly associated with survival in metastatic cervical cancer. (4) Conclusions: Tumor size ≤6.9 cm and concurrent chemoradiotherapy as the primary treatment were favorable prognostic factors for patients with metastatic cervical cancer.


Medicine ◽  
2015 ◽  
Vol 94 (36) ◽  
pp. e1404 ◽  
Author(s):  
Young Jin Yoo ◽  
Seok Jeong Yang ◽  
Ho Kyoung Hwang ◽  
Chang Moo Kang ◽  
Hogeun Kim ◽  
...  

2012 ◽  
Vol 15 (5) ◽  
pp. 358-363 ◽  
Author(s):  
F. Mera-Menéndez ◽  
A. Hinojar-Gutiérrez ◽  
M. Guijarro Rojas ◽  
J. García de Gregorio ◽  
E. Mera-Menéndez ◽  
...  

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