scholarly journals Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaoqiang Li ◽  
Xuanfeng Ding ◽  
Weili Zheng ◽  
Gang Liu ◽  
Guillaume Janssens ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Organs At Risk ◽  
Substantial Improvement ◽  
Intensity Modulated Proton Therapy ◽  
Spot Scanning ◽  
Similar Dose ◽  
Arc Therapy ◽  
Clinical Benefits ◽  
Delivery Efficiency

PurposeTo integrate dose-averaged linear energy transfer (LETd) into spot-scanning proton arc therapy (SPArc) optimization and to explore its feasibility and potential clinical benefits.MethodsAn open-source proton planning platform (OpenREGGUI) has been modified to incorporate LETd into optimization for both SPArc and multi-beam intensity-modulated proton therapy (IMPT) treatment planning. SPArc and multi-beam IMPT plans with different beam configurations for a prostate patient were generated to investigate the feasibility of LETd-based optimization using SPArc in terms of spatial LETd distribution and plan delivery efficiency. One liver and one brain case were studied to further evaluate the advantages of SPArc over multi-beam IMPT.ResultsWith similar dose distributions, the efficacy of spatially optimizing LETd distributions improves with increasing number of beams. Compared with multi-beam IMPT plans, SPArc plans show substantial improvement in LETd distributions while maintaining similar delivery efficiency. Specifically, for the liver case, the average LETd in the GTV was increased by 124% for the SPArc plan, and only 9.6% for the 2-beam IMPT plan compared with the 2-beam non-LETd optimized IMPT plan. In case of LET optimization for the brain case, the SPArc plan could effectively increase the average LETd in the CTV and decrease the values in the critical structures while smaller improvement was observed in 3-beam IMPT plans.ConclusionThis work demonstrates the feasibility and significant advantages of using SPArc for LETd-based optimization, which could maximize the LETd distribution wherever is desired inside the target and averts the high LETd away from the adjacent critical organs-at-risk.

scholarly journals Robust intensity-modulated proton therapy to reduce high linear energy transfer in organs at risk

2017 ◽  
Vol 44 (12) ◽  
pp. 6138-6147 ◽  
Author(s):  
Yu An ◽  
Jie Shan ◽  
Samir H. Patel ◽  
William Wong ◽  
Steven E. Schild ◽  
...  
Keyword(s):  
At Risk ◽  
Energy Transfer ◽  
Proton Therapy ◽  
Linear Energy Transfer ◽  
Organs At Risk ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
High Linear Energy Transfer

scholarly journals Dosimetric Comparison of Helical Tomotherapy, Volumetric-Modulated Arc Therapy, and Intensity-Modulated Proton Therapy for Angiosarcoma of the Scalp

2021 ◽  
Vol 20 ◽  
pp. 153303382098586
Author(s):  
Tomoki Mizuno ◽  
Natsuo Tomita ◽  
Taiki Takaoka ◽  
Masashi Tomida ◽  
Hiroshi Fukuma ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Helical Tomotherapy ◽  
Organs At Risk ◽  
Volumetric Modulated Arc Therapy ◽  
Target Volume ◽  
The Other ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Arc Therapy ◽  
Dose Constraint

Objective: We compared radiotherapy plans among helical tomotherapy (HT), volumetric-modulated arc therapy (VMAT), and intensity-modulated proton therapy (IMPT) for angiosarcoma of the scalp (AS). Methods: We conducted a planning study for 19 patients with AS. The clinical target volume (CTV) 1 and CTV2 were defined as the gross tumor volume with a specific margin and total scalp, respectively. For HT and VMAT, the planning target volume (PTV) 1 and PTV2 were defined as CTV1 and CTV2 with 0.5-cm margins, respectively. For IMPT, robust optimization was used instead of a CTV-PTV margin (i.e. CTV robust). The targets of the HT and VMAT plans were the PTV, whereas the IMPT plans targeted the CTV robust. In total, 70 Gy and 56 Gy were prescribed as the D95% (i.e. dose to 95% volume) of PTV1 (or CTV1 robust) and PTV2 (or CTV2 robust), respectively, using the simultaneous integrated boost (SIB) technique. Other constraint goals were also defined for the target and organs at risk (OAR). Results: All dose constraint parameters for the target and OAR met the goals within the acceptable ranges for the 3 techniques. The coverage of the targets replaced by D95% and D98% were almost equivalent among the 3 techniques. The homogeneity index of PTV1 or CTV1 robust was equivalent among the 3 techniques, whereas that of PTV2 or CTV2 robust was significantly higher in the IMPT plans than in the other plans. IMPT reduced the Dmean of the brain and hippocampus by 49% to 95%, and the Dmax of the spinal cord, brainstem, and optic pathway by 70% to 92% compared with the other techniques. Conclusion: The 3 techniques with SIB methods provided sufficient coverage and satisfactory homogeneity for the targets, but IMPT achieved the best OAR sparing.

scholarly journals Biological dose and complication probabilities for the rectum and bladder based on linear energy transfer distributions in spot scanning proton therapy of prostate cancer

2017 ◽  
Vol 56 (11) ◽  
pp. 1413-1419 ◽  
Author(s):  
Jesper Pedersen ◽  
Jørgen B. B. Petersen ◽  
Camilla H. Stokkevåg ◽  
Kristian S. Ytre-Hauge ◽  
Stella Flampouri ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Energy Transfer ◽  
Proton Therapy ◽  
Linear Energy Transfer ◽  
Spot Scanning ◽  
Biological Dose

scholarly journals Linear energy transfer distributions in the brainstem depending on tumour location in intensity-modulated proton therapy of paediatric cancer

2017 ◽  
Vol 56 (6) ◽  
pp. 763-768 ◽  
Author(s):  
Lars Fredrik Fjæra ◽  
Zuofeng Li ◽  
Kristian S. Ytre-Hauge ◽  
Ludvig P. Muren ◽  
Daniel J. Indelicato ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Proton Therapy ◽  
Linear Energy Transfer ◽  
Paediatric Cancer ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Tumour Location
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