scholarly journals Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Qigen Fang ◽  
Yao Wu ◽  
Wei Du ◽  
Xu Zhang ◽  
Defeng Chen
Keyword(s):  
Salivary Gland ◽  
Tumor Cells ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Tumor Stage ◽  
Advanced Tumor Stage ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Gland Carcinoma ◽  
The Difference

ObjectivePD-L1 is one of the predictors of immunotherapy efficacy. Our goal was to analyze its expression and prognostic significance in high-grade salivary gland carcinoma (SGC).MethodsPD-L1 expression was evaluated using paraffin-embedded specimens from patients with surgically treated high-grade SGC, and it was scored by the tumor proportion score (TPS), combined positive score (CPS), and immune cell (IC) score. Associations between clinicopathological variables, disease-free survival (DFS), overall survival (OS) and PD-L1 expression were assessed.ResultsTPS≥1% occurred in 47 patients with an incidence of 43.1%, and it was significantly related to an advanced tumor stage. In patients with TPS<1%, TPS ranging from 1% to 20%, and TPS≥20%, the 5-year DFS rates were 36%, 26%, and 13%, respectively, and the difference was significant. In patients with TPS<1%, TPS ranging from 1% to 20%, and TPS≥20%, the 5-year OS rates were 49%, 24%, and 13%, respectively, and the difference was significant. CPS≥1 occurred in 87 patients with an incidence of 79.8%. IC scores of 0, 1, 2, and 3 were noted in 24 (22.0%), 37 (33.9%), 31 (28.4%), and 17 (15.6%) patients, respectively. Both CPS and IC scores had no impact on DFS or OS.ConclusionsThe expression of PD-L1 in tumor cells of high-grade SGCs was not uncommon, and it was significantly associated with tumor stage. PD-L1 expression in tumor cells rather than in immune cells indicated a poor prognosis.

Pre-treatment metabolic tumor volume predicts tumor metastasis and progression in high-grade salivary gland carcinoma

2018 ◽  
Vol 144 (12) ◽  
pp. 2485-2493
Author(s):  
Turki M. Almuhaimid ◽  
Won Sub Lim ◽  
Jong-Lyel Roh ◽  
Jungsu S. Oh ◽  
Jae Seung Kim ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Tumor Metastasis ◽  
Tumor Volume ◽  
Metabolic Tumor Volume ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Gland Carcinoma ◽  
Pre Treatment

scholarly journals Prognostic Significance of Preoperative and Postoperative Complement C3 Depletion in Gastric Cancer: A Three-Year Survival Investigation

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jinning Ye ◽  
Yufeng Ren ◽  
Jianhui Chen ◽  
Wu Song ◽  
Chuangqi Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Significance ◽  
Hospital Costs ◽  
Disease Free Survival ◽  
Tumor Stage ◽  
Complement C3 ◽  
Advanced Tumor Stage ◽  
Advanced Tumor ◽  
Prolonged Hospital

Objectives. The role of complement system in predicting prognosis of gastric cancer (GC) remains obscured. This study aims to explore the incidence of complement C3 depletion and associated outcomes in GC patients. Methods. between August 2013 and December 2013, 106 patients with gastric adenocarcinoma were prospectively analyzed. Plasma levels of complement C3 and C4 were detected at baseline, one day before surgery, and postoperative day 3, respectively. Patients with low C3 levels (<0.75 mg/mL) were considered as having complement depletion (CD), while others with normal C3 levels were included as control. The 3-year overall survival (OS), disease-free survival (DFS), and other outcomes were compared between both groups, with the CD incidence explored meanwhile. Results. The CD incidence was 28.3% before surgery but increased to 37.7% after surgery. Preoperative CD was related to prolonged hospital stay (22.7 versus 19.2 day, P=0.032) and increased postoperative complications (33.3% versus 14.5%, P=0.030) and hospital costs (P=0.013). Besides, postoperative C3 depletion was significantly associated with decreased 3-year OS (P=0.022) and DFS (P=0.003). Moreover, postoperative C3 depletion and advanced tumor stage were independent predictive factors of poor prognosis. Conclusions. Complement C3 depletion occurring in gastric cancer was associated with poor short-term and long-term outcomes.

HPV-Related Multiphenotypic Sinonasal Carcinoma: A Unique Case

2019 ◽  
Vol 27 (8) ◽  
pp. 888-892 ◽  
Author(s):  
Daniel Ching ◽  
Shadi Pirasteh ◽  
Chanh Ly
Keyword(s):  
Salivary Gland ◽  
Human Papillomavirus ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Unique Case ◽  
Sinonasal Carcinoma ◽  
Adenoid Cystic ◽  
Gland Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma ◽  
High Risk Hpv

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a recently described neoplasm that presents only in the sinonasal tract, displays features of both a surface-derived carcinoma and a salivary gland carcinoma, and is associated with high-risk HPV, specifically HPV type 33. Majority of the cases display high-grade histologic features, but HMSC paradoxically behaves in a relatively indolent fashion. Distinguishing HMSC from other histologic mimickers is essential as the management and prognosis are significantly different. In this article, we present a unique case of HMSC and review the literature.

Elective neck management for high-grade salivary gland carcinoma

2013 ◽  
Vol 34 (3) ◽  
pp. 205-208 ◽  
Author(s):  
Michael P. Herman ◽  
John W. Werning ◽  
Christopher G. Morris ◽  
Jessica M. Kirwan ◽  
Robert J. Amdur ◽  
...  
Keyword(s):  
Salivary Gland ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Gland Carcinoma
Sign in / Sign up

Export Citation Format

Share Document