scholarly journals Sintilimab and Chidamide for Refractory Transformed Diffuse Large B Cell Lymphoma: A Case Report and A Literature Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Chao Chen ◽  
Wei Zhang ◽  
Daobin Zhou ◽  
Yan Zhang
Keyword(s):  
Combination Therapy ◽  
B Cell ◽  
Lymphoid Tissue ◽  
Cell Lymphoma ◽  
Single Case ◽  
B Cell Lymphoma ◽  
New Combination ◽  
Large B Cell Lymphoma ◽  
Therapeutic Possibilities ◽  
Large B Cell

Patients with relapsed/refractory (R/R) transformed diffused large B cell lymphoma (tDLBCL) have a poor prognosis and a low survival rate. In addition, no standard therapy has yet been established for R/R tDLBCL. Herein we presented a single case of a patient with R/R tDLBCL who was successfully treated with sintilimab and chidamide. The patient was a 71-year-old man with pulmonary mucosa-associated lymphoid tissue lymphoma. He did not receive any treatment until tDLBCL was confirmed 2 years later. The tDLBCL was primary refractory to R2-CHOP, R2-MTX, and Gemox regimens. However, the patient achieved sustained complete remission after the combination therapy of sintilimab and chidamide. To the best of our knowledge, this is the first report of sintilimab combined with chidamide for the treatment of R/R tDLBCL, which opens up new therapeutic possibilities for this new combination therapy in future prospective clinical trials.

Diffuse Large B-Cell Lymphoma Transformed from a Rectal Mucosa-Associated Lymphoid Tissue Lymphoma

2016 ◽  
Vol 39 (2) ◽  
pp. 51
Author(s):  
Sae Han Kang ◽  
Jang Won Park ◽  
Byung Wook Jung ◽  
Jun Gyu Song ◽  
Hyun Sik Oh ◽  
...  
Keyword(s):  
B Cell ◽  
Lymphoid Tissue ◽  
Cell Lymphoma ◽  
Rectal Mucosa ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Recurrence of Nodal Diffuse Large B-Cell Lymphoma as Intravascular Large B-Cell Lymphoma: Is an Intravascular Component at Initial Diagnosis Predictive?

2005 ◽  
Vol 129 (3) ◽  
pp. 391-394
Author(s):  
Xian-Feng Zhao ◽  
Amy M. Sands ◽  
Peter T. Ostrow ◽  
Regina Halbiger ◽  
James T. Conway ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Single Case ◽  
Multiorgan Failure ◽  
Molecular Genetic ◽  
B Cell Lymphoma ◽  
Initial Diagnosis ◽  
Chain Gene ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract We report a case of a 59-year-old man who first presented with a nodal diffuse large B-cell lymphoma that later relapsed as an intravascular large B-cell lymphoma. In the initial biopsy specimen, a few intranodal small vessels that contained large lymphoma cells were noted. After 8 months of multiagent chemotherapy, clinical remission was attained. Two years after the initial diagnosis of nodal diffuse large B-cell lymphoma, the patient presented with a rapid onset of multiorgan failure, which at autopsy was shown to be due to intravascular large B-cell lymphoma. Molecular genetic studies showed that these 2 lymphomas had immunoglobulin heavy-chain gene rearrangements that were of identical size, suggesting that they were derived from the same clone. To our knowledge, this is the first report of a nodal large B-cell lymphoma that relapsed as an intravascular large B-cell lymphoma. Although this report is of only a single case, the presence of a relatively inconspicuous intravascular component in an otherwise typical nodal large B-cell lymphoma may be predictive and could affect clinical decisions regarding diagnosis, monitoring, and prognosis of such lymphomas.

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