Objectives: To evaluate the protective effects of combination of extracts of Oleaeuropeae and Ginkgo biloba in response to hematological toxicosis induced by DOX. Designof study: Animal experimental study. Setting: Dow University of Health Sciences. Period: 2month. Materials & methods: The extracts of Olea europeae and Ginkgo biloba were preparedby using standard Soxhlet apparatus and then they were mixed together in 1:1 ratio. EighteenMale Wistar rats were incorporated in the study and divided in 3 groups: T* (control group: 2ml 0.9 % NS), TP0 (DOX group: 15 mg/kg/week) and TP1 (extract of Olea europeae & Ginkgobiloba + DOX: 200 + 15 mg/kg/week). All animals receive drugs by intra-peritoneal route. On57th day blood was withdrawn by cardiac puncture and preserved for analysis. Hematologicalprofile includes CBC and Platelet count. Results: Hematological analysis reveals that theanimals which receive Doxorubicin had low levels of Hemoglobin, RBCs, Leukocytes,Neutrophils, Eosinophils, Monocytes, Lymphocytes and Platelets when compared to controlgroup. The levels of Hb and RBCs were low but it is not evident of anemia. Neutrophil andPlatelet were drastically low, which shows presence of Neutropenia and Thrombocytopenia.The treated group animals had shown positive elevation in the levels of CBC and Platelet count.Conclusions: On the basis of hematological report it is concluded that combination of extractsof Olea europeae and Ginkgo biloba can prevent the toxicosis effects of Doxorubicin.
A standardized extract of Ginkgo biloba prevents locomotion impairment induced by cassava juice in Wistar rats
