scholarly journals Non-linear Amplification of Variability Through Interaction Across Scales Supports Greater Accuracy in Manual Aiming: Evidence From a Multifractal Analysis With Comparisons to Linear Surrogates in the Fitts Task

2019 ◽  
Vol 10 ◽  
Author(s):  
Christopher A. Bell ◽  
Nicole S. Carver ◽  
John A. Zbaracki ◽  
Damian G. Kelty-Stephen
2019 ◽  
Vol 23 ◽  
pp. 233121651988761 ◽  
Author(s):  
Gilles Courtois ◽  
Vincent Grimaldi ◽  
Hervé Lissek ◽  
Philippe Estoppey ◽  
Eleftheria Georganti

The auditory system allows the estimation of the distance to sound-emitting objects using multiple spatial cues. In virtual acoustics over headphones, a prerequisite to render auditory distance impression is sound externalization, which denotes the perception of synthesized stimuli outside of the head. Prior studies have found that listeners with mild-to-moderate hearing loss are able to perceive auditory distance and are sensitive to externalization. However, this ability may be degraded by certain factors, such as non-linear amplification in hearing aids or the use of a remote wireless microphone. In this study, 10 normal-hearing and 20 moderate-to-profound hearing-impaired listeners were instructed to estimate the distance of stimuli processed with different methods yielding various perceived auditory distances in the vicinity of the listeners. Two different configurations of non-linear amplification were implemented, and a novel feature aiming to restore a sense of distance in wireless microphone systems was tested. The results showed that the hearing-impaired listeners, even those with a profound hearing loss, were able to discriminate nearby and far sounds that were equalized in level. Their perception of auditory distance was however more contracted than in normal-hearing listeners. Non-linear amplification was found to distort the original spatial cues, but no adverse effect on the ratings of auditory distance was evident. Finally, it was shown that the novel feature was successful in allowing the hearing-impaired participants to perceive externalized sounds with wireless microphone systems.


2021 ◽  
Author(s):  
Karina Loviknes ◽  
Danijel Schorlemmer ◽  
Fabrice Cotton ◽  
Sreeram Reddy Kotha

<p>Non-linear site effects are mainly expected for strong ground motions and sites with soft soils and more recent ground-motion models (GMM) have started to include such effects. Observations in this range are, however, sparse, and most non-linear site amplification models are therefore partly or fully based on numerical simulations. We develop a framework for testing of non-linear site amplification models using data from the comprehensive Kiban-Kyoshin network in Japan. The test is reproducible, following the vision of the Collaboratory for the Study of Earthquake Predictability (CSEP), and takes advantage of new large datasets to evaluate <span>whether or not</span> non-linear site effects predicted by site-amplification models are supported by empirical data. The site amplification models are tested using residuals between the observations and predictions from a GMM based only on magnitude and distance. When the GMM is derived without any site term, the site-specific variability extracted from the residuals is expected to capture the site response of a site. The non-linear site amplification models are tested against a linear amplification model on individual well-record<span>ing</span> stations. Finally, the result is compared to building codes where non-linearity is included. The test shows that for most of the sites selected as having sufficient records, the non-linear site-amplification models do not score better than the linear amplification model. This suggests that including non-linear site amplification in GMMs and building codes may not yet be justified, at least not in the range of ground motions considered in the test (peak ground acceleration < 0.2 g).</p>


2018 ◽  
Vol 221 (12) ◽  
pp. jeb179085 ◽  
Author(s):  
Juha Rusanen ◽  
Roman Frolov ◽  
Matti Weckström ◽  
Michiyo Kinoshita ◽  
Kentaro Arikawa

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Yeonee Seol ◽  
Gábor M Harami ◽  
Mihály Kovács ◽  
Keir C Neuman

RecQ helicases promote genomic stability through their unique ability to suppress illegitimate recombination and resolve recombination intermediates. These DNA structure-specific activities of RecQ helicases are mediated by the helicase-and-RNAseD like C-terminal (HRDC) domain, via unknown mechanisms. Here, employing single-molecule magnetic tweezers and rapid kinetic approaches we establish that the HRDC domain stabilizes intrinsic, sequence-dependent, pauses of the core helicase (lacking the HRDC) in a DNA geometry-dependent manner. We elucidate the core unwinding mechanism in which the unwinding rate depends on the stability of the duplex DNA leading to transient sequence-dependent pauses. We further demonstrate a non-linear amplification of these transient pauses by the controlled binding of the HRDC domain. The resulting DNA sequence- and geometry-dependent pausing may underlie a homology sensing mechanism that allows rapid disruption of unstable (illegitimate) and stabilization of stable (legitimate) DNA strand invasions, which suggests an intrinsic mechanism of recombination quality control by RecQ helicases.


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