scholarly journals Cerebral Metabolic Changes During Visuomotor Adaptation Assessed Using Quantitative fMRI

2020 ◽  
Vol 11 ◽  
Author(s):  
Catherine Foster ◽  
Jessica J. Steventon ◽  
Daniel Helme ◽  
Valentina Tomassini ◽  
Richard G. Wise
Keyword(s):  
Visuomotor Adaptation ◽  
Metabolic Changes

scholarly journals Cerebral Metabolic Changes during Visuomotor Adaptation Assessed using Quantitative FMRI

2019 ◽  
Author(s):  
Catherine Foster ◽  
Jessica J Steventon ◽  
Daniel Helme ◽  
Valentina Tomassini ◽  
Richard G. Wise
Keyword(s):  
Brain Plasticity ◽  
Reaction Time Task ◽  
Visuomotor Adaptation ◽  
Brain Regions ◽  
Metabolic Changes ◽  
Mean Flow ◽  
Coupling Ratio ◽  
Healthy Human ◽  
Task Adaptation ◽  
Calibrated Fmri

AbstractThe neural energetics underlying functional brain plasticity have not been thoroughly investigated in the healthy human brain. A better understanding of the blood flow and metabolism changes underlying plasticity will help us to address pathologies in which plasticity is compromised and, with interventions, could be enhanced for patient benefit.Calibrated fMRI was conducted in 20 healthy participants during performance of a serial reaction time task which induces rapid motor adaptation. Regions of interest (ROIs) were defined from areas showing linearly decreasing task-induced BOLD and CBF responses. BOLD, CBF and relative CMRO2 responses were calculated for each block of the task. The flow-metabolism coupling ratio, n, was also calculated for each ROI. Increases from baseline in BOLD, CBF and CMRO2 were observed in multiple brain regions including the motor and sensorimotor cortices, cerebellum and hippocampus during SRT task performance, as well as changes in the response amplitude from early to late task blocks reflecting task adaptation. CMRO2 responses on average decreased faster than BOLD or CBF responses, potentially due to rapid neural adaptation. However, the mean flow-metabolism coupling ratio was not significantly different between ROIs or across blocks.Calibrated fMRI can be used to study energetic changes during learning in the healthy brain and could be used to investigate the vascular and metabolic changes underlying reductions in plasticity in ageing and disease.

A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

1975 ◽  
Vol 33 ◽  
pp. 460-461
Author(s):  
Sidney D. Kobernick ◽  
Edna A. Elfont ◽  
Neddra L. Brooks
Keyword(s):  
Lipid Metabolism ◽  
New Zealand ◽  
Aortic Wall ◽  
Rabbit Aorta ◽  
Plaque Formation ◽  
Metabolic Changes ◽  
Atherosclerotic Plaques ◽  
Cytochemical Study ◽  
Cellular Alteration ◽  
New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

Metabolic Changes During Behavioral Thermoregulation

1965 ◽  
Author(s):  
Ivan Barofsky
Keyword(s):  
Metabolic Changes ◽  
Behavioral Thermoregulation

Antipsychotic Rx May Mean Metabolic Changes

2005 ◽  
Vol 35 (10) ◽  
pp. 34
Author(s):  
DIANA MAHONEY
Keyword(s):  
Metabolic Changes

Antipsychotic Drugs Spur Metabolic Changes

2010 ◽  
Vol 40 (12) ◽  
pp. 38
Author(s):  
BETSY BATES
Keyword(s):  
Antipsychotic Drugs ◽  
Metabolic Changes

Platelet Metabolism during the Interiorization of Two Different Types of Particulate Matter

1972 ◽  
Vol 27 (02) ◽  
pp. 263-271 ◽  
Author(s):  
I. A. Cooper ◽  
P Cochrane ◽  
B. G. Firkin ◽  
K. J. Pinkard
Keyword(s):  
Particulate Matter ◽  
Polymorphonuclear Leukocyte ◽  
Anaerobic Metabolism ◽  
Human Platelets ◽  
Metabolic Changes ◽  
Polystyrene Latex ◽  
Considerable Time ◽  
Difference Of Opinion ◽  
Different Types ◽  
Aerobic And Anaerobic

SummaryIt has been suggested that human platelets possess the ability to phagocytose particulate matter similar to the polymorphonuclear leukocyte. However some difference of opinion has arisen regarding this contention, particularly as differences have been demonstrated with regard to the observed metabolic changes occurring in platelets related to such a process.The experiments reported in this paper were designed to observe the aerobic and anaerobic metabolism in human platelets during and following interiorization of two different particles, viz. polystyrene latex and thorotrast. The results of these experiments show a marked difference between both types of particles with regard to observable metabolic changes despite the rapid interiorization of both types of material. Some alteration occurs in both aerobic and anaerobic metabolism a considerable time after interiorization of latex, whereas no alteration could be demonstrated after interiorization of thorotrast. It is suggested that the interiorization of particulate matter is by some process other than phagocytosis and that observed metabolic changes related to latex may be due to a release reaction.

Thyroid dysfunctions and metabolic changes in centenarians: consequence or cause of longevity?

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
M Kleinhardt ◽  
D Nicula ◽  
T Thomas ◽  
G Brabant ◽  
M Derwahl
Keyword(s):  
Metabolic Changes ◽  
Thyroid Dysfunctions

Ultra-trail marathon induces bone response in association with acute and established metabolic changes

2016 ◽  
Author(s):  
Giovanni Lombardi ◽  
Veronica Sansoni ◽  
Silvia Perego ◽  
Gianluca Vernillo ◽  
Federico Schena ◽  
...  
Keyword(s):  
Metabolic Changes ◽  
Bone Response
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