scholarly journals Mesenchymal Bmp7 Controls Onset of Tooth Mineralization: A Novel Way to Regulate Molar Cusp Shape

2020 ◽  
Vol 11 ◽  
Author(s):  
Zeba Malik ◽  
Daniela M. Roth ◽  
Farah Eaton ◽  
Jessica M. Theodor ◽  
Daniel Graf
Keyword(s):  
Tooth Mineralization ◽  
Cusp Shape

Cusp-shape studies withHe+ions at 1.41- and 2.41-a.u. impact velocities

1992 ◽  
Vol 45 (7) ◽  
pp. 4535-4541 ◽  
Author(s):  
L. Gulyás ◽  
L. Sarkadi ◽  
J. Pálinkás ◽  
Á. Kövér ◽  
T. Vajnai ◽  
...  
Keyword(s):  
Cusp Shape

A multivariate approach to assess variation in tooth mineralization using free-lived and captive-raised chimpanzees (P. troglodytes)

2015 ◽  
Vol 158 (3) ◽  
pp. 452-462 ◽  
Author(s):  
Julia C. Boughner ◽  
Jasmine Der ◽  
Kevin L. Kuykendall
Keyword(s):  
Multivariate Approach ◽  
Tooth Mineralization

Effects of Enzyme Replacement Therapy for Primary Teeth in a Patient with Infantile Hypophosphatasia

2020 ◽  
Vol 44 (5) ◽  
pp. 348-351
Author(s):  
Rena Okawa ◽  
Saaya Matayoshi ◽  
Rina Kariya ◽  
Yuko Ogaya ◽  
Ryota Nomura ◽  
...  
Keyword(s):  
Enzyme Replacement Therapy ◽  
Replacement Therapy ◽  
Primary Teeth ◽  
Alveolar Bone ◽  
Primary Molars ◽  
Enzyme Replacement ◽  
Tooth Mineralization ◽  
Old Japanese ◽  
Skeletal Disorder ◽  
Phosphatase Enzyme

Hypophosphatasia (HPP) is a skeletal disorder characterized by hypomineralization of bone, with early exfoliation of primary teeth. Alkaline phosphatase enzyme replacement therapy (ERT) has been shown to improve bone hypomineralization for patients with HPP, although its dental effects are unknown. A 20-month-old Japanese boy diagnosed with infantile HPP was referred to our clinic because of early exfoliation of primary teeth. The patient had been followed by a pediatrician since the age of 3 months, due to slow weight gain. At the age of 12 months, primary incisors showed sudden exfoliation; at the age of 19 months, a diagnosis of HPP was made based on bone and dental manifestations. ERT was initiated at the age of 21 months. The patient demonstrated stable periodontal conditions of primary molars that erupted after initiation of ERT, due to improved alveolar bone and tooth mineralization. Thus, ERT may improve both dental and systemic conditions.

An example of regional variation in the tempos of tooth mineralization and hand-wrist ossification

1992 ◽  
Vol 101 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Mark S. Mappes ◽  
Edward F. Harris ◽  
Rolf G. Behrents
Keyword(s):  
Regional Variation ◽  
Tooth Mineralization

Lactational Exposure of Han/Wistar Rats to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Interferes with Enamel Maturation and Retards Dentin Mineralization

2004 ◽  
Vol 83 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Y. Gao ◽  
C. Sahlberg ◽  
A. Kiukkonen ◽  
S. Alaluusua ◽  
R. Pohjanvirta ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Cell Function ◽  
Causative Factor ◽  
Enamel Matrix ◽  
Lactational Exposure ◽  
Aryl Hydrocarbon ◽  
Tooth Mineralization ◽  
Cyp1a1 Expression ◽  
Enamel Mineralization ◽  
Tetrachlorodibenzo P Dioxin

Exposure to environmental dioxins via mother’s milk may be one causative factor of mineralization defects in children’s teeth. A prerequisite for the completion of enamel mineralization is the removal of enamel matrix. To test the hypothesis that dioxins interfere with enamel maturation, we administered lactating Han/Wistar rats a single dose of 2,3,7,8-tetrachlorodibenzo -p-dioxin (TCDD; 50 or 1000 μg/kg) on the day after delivery and analyzed tissue sections of the pup heads at post-natal days (Pn) 9 and 22. By Pn22, the first and second molars of the exposed pups, but not controls, showed retention of enamel matrix. Predentin was thicker than normal. Immunostaining for the aryl hydrocarbon/dioxin receptor (AhR) and cytochrome P4501A1 (CYP1A1) in ameloblasts and odontoblasts was reduced, suggesting that TCDD interferes with tooth mineralization via AhR. Extinction of AhR may lead to abolition of CYP1A1 expression as a sign of impaired dental cell function.

On the cusp shape of hyperbolic knots

2016 ◽  
Vol 25 (05) ◽  
pp. 1650025
Author(s):  
Yoshiyuki Yokota
Keyword(s):  
Potential Functions ◽  
Volume Conjecture ◽  
Cusp Shape

In this paper, we give a formula of the cusp shape of hyperbolic knots by using potential functions which appears in the study of the volume conjecture.

scholarly journals Tooth Mineralization: A Technical Note on the Moorrees-Fanning-Hunt Standards

2018 ◽  
Vol 16 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Edward F. Harris ◽  
Andrea L. Buck
Keyword(s):  
Longitudinal Studies ◽  
Short Communication ◽  
Technical Note ◽  
Growing Up ◽  
Graphic Form ◽  
Tooth Mineralization ◽  
Standard Deviations

One of the largest, longitudinal studies of tooth mineralization is that described by Moorrees, Fanning and Hunt (J Dent Res, 1963) based on children growing up in Boston, Massachusetts, and Yellow Springs, Ohio. This short communication provides tables of the means and standard deviations, by sex, in order to make the data more accessible and usable than the graphic form of the information in the original article. Characteristics of the study and applications are discussed.

Bone Morphogenetic Protein 2 Coordinates Early Tooth Mineralization

2018 ◽  
Vol 97 (7) ◽  
pp. 835-843 ◽  
Author(s):  
Z. Malik ◽  
M. Alexiou ◽  
B. Hallgrimsson ◽  
A.N. Economides ◽  
H.U. Luder ◽  
...  
Keyword(s):  
Tooth Development ◽  
Bmp Signaling ◽  
Conditional Knockout ◽  
Bone Morphogenetic Protein 2 ◽  
Micro Computed Tomography ◽  
Tooth Mineralization ◽  
Morphogenetic Protein ◽  
Dental Hard Tissues ◽  
Dentin Sialoprotein ◽  
Tooth Germs

Formation of highly organized dental hard tissues is a complex process involving sequential and ordered deposition of an extracellular scaffold, followed by its mineralization. Odontoblast and ameloblast differentiation involves reciprocal and sequential epithelial-mesenchymal interactions. Similar to early tooth development, various Bmps are expressed during this process, although their functions have not been explored in detail. Here, we investigated the role of odontoblast-derived Bmp2 for tooth mineralization using Bmp2 conditional knockout mice. In developing molars, Bmp2LacZ reporter mice revealed restricted expression of Bmp2 in early polarized and functional odontoblasts while it was not expressed in mature odontoblasts. Loss of Bmp2 in neural crest cells, which includes all dental mesenchyme, caused a delay in dentin and enamel deposition. Immunohistochemistry for nestin and dentin sialoprotein (Dsp) revealed polarization defects in odontoblasts, indicative of a role for Bmp2 in odontoblast organization. Surprisingly, pSmad1/5/8, an indicator of Bmp signaling, was predominantly reduced in ameloblasts, with reduced expression of amelogenin ( Amlx), ameloblastin ( Ambn), and matrix metalloproteinase ( Mmp20). Quantitative real-time polymerase chain reaction (RT-qPCR) analysis and immunohistochemistry showed that loss of Bmp2 resulted in increased expression of the Wnt antagonists dickkopf 1 ( Dkk1) in the epithelium and sclerostin ( Sost) in mesenchyme and epithelium. Odontoblasts showed reduced Wnt signaling, which is important for odontoblast differentiation, and a strong reduction in dentin sialophosphoprotein ( Dspp) but not collagen 1 a1 ( Col1a1) expression. Mature Bmp2-deficient teeth, which were obtained by transplanting tooth germs from Bmp2-deficient embryos under a kidney capsule, showed a dentinogenesis imperfecta type II–like appearance. Micro–computed tomography and scanning electron microscopy revealed reduced dentin and enamel thickness, indistinguishable primary and secondary dentin, and deposition of ectopic osteodentin. This establishes that Bmp2 provides an early temporal, nonredundant signal for directed and organized tooth mineralization.

scholarly journals Micro-computed tomography imaging reveals the development of a unique tooth mineralization pattern in mackerel sharks (Chondrichthyes; Lamniformes) in deep time

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Patrick L. Jambura ◽  
René Kindlimann ◽  
Faviel López-Romero ◽  
Giuseppe Marramà ◽  
Cathrin Pfaff ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Micro Computed Tomography ◽  
Computed Tomography Imaging ◽  
Deep Time ◽  
Tomography Imaging ◽  
Tooth Mineralization
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