scholarly journals Evolution of Substance use, Neurological and Psychiatric Symptoms in Schizophrenia and Substance use Disorder Patients: A 12-Week, Pilot, Case–Control Trial with Quetiapine

2011 ◽  
Vol 2 ◽  
Author(s):  
Simon Zhornitsky ◽  
Emmanuel Stip ◽  
Joelle Desfossés ◽  
Tania Pampoulova ◽  
Élie Rizkallah ◽  
...  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Najmeh Shahini ◽  
Ali Talaei ◽  
Zanireh Salimi ◽  
Moussalreza Adinepour Sarab ◽  
Shakiba Gholamzad ◽  
...  

Abstract Background Patients with Substance use disorder have distinct personality traits, they were high score in novelty seeking (NS) and sensation seeking and lower in Self-directedness and higher in Self-transcendence, so we aim to investigate the relationships of temperament and characteristics with related some variables such as substance of choice. Design and setting A case–control study enrolling 70 Substance use disorder patients and 70 controls was conducted at Mashhad University of medical sciences. Methods Using a case–control design, a group of 70 Substance use disorder patients and 70 controls was conducted at Mashhad university of medical sciences. All participation completed the 240 questions of Temperament and Character Inventory-Revised (TCI-R). Multivariate analysis of covariance (MANCOVA) was employed to compare the relationship between temperament and character traits and patterns of substance use. Results The scores of reward dependence, persistence, self-directedness, cooperativeness, and self-transcendence were significantly lower in the case group compared to healthy individuals (P < 0.05). In contrast, the score of novel seeking was significantly higher in the case group (P < 0.05). On the other hand, harm avoidance was not significantly different between the two studied groups (P = 0.637). Conclusions Higher NS in patients with substance use disorder is common and different traits, and temperaments would choose different substance combinations.


Author(s):  
Dennis C. Daley ◽  
Antoine Douaihy

The term “co-occurring disorders” refers to the presence of a psychiatric disorder and a substance use disorder. A psychiatric disorder increases the risk of a substance use disorder and vice versa. Treating one disorder improves the outcomes in treating the other. Psychiatric medications can be both effective and appropriate in treating the psychiatric disorder in people with co-occurring disorders. Medication-assisted treatment (MAT) can treat effectively the substance use disorder in people with co-occurring disorders. The goals of this chapter are to learn about the different types of psychiatric disorders, to learn about the causes of psychiatric disorders, and to assess the client’s psychiatric symptoms, if applicable.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ely M. Marceau ◽  
Gabriella Holmes ◽  
Jane Cutts ◽  
Lauren Mullaney ◽  
Denise Meuldijk ◽  
...  

Abstract Background Reducing substance use in youth is a global health priority. We compared two cohorts from the same 12-week residential substance use disorder (SUD) facility over a 10 year period: Cohort A (2008–2009) and Cohort B (2018–2020). The essential components of the program remained the same with the primary treatment being dialectical behaviour therapy (DBT) plus residential milieu. Methods Young people in the current Cohort B (N = 100) versus historical Cohort A (N = 102) had a similar ratio of males (74 vs. 70%) but were slightly older (mean 20.6 vs. 19.5 years). Linear mixed models were used to model outcome measures (global psychiatric symptoms, substance use severity, and quality of life) longitudinally up to 12 months later. Results Baseline to end-of-treatment comparisons showed that the current Cohort B had overall higher levels of global psychiatric symptoms (d = 0.70), but both groups reduced psychiatric symptoms (Cohort A: d = 1.05; Cohort B: d = 0.61), and had comparable increases in confidence to resist substance use (d = 0.95). Longitudinal data from the current Cohort B showed significant decreases in substance use severity from baseline to 6-month follow-up (d = 1.83), which were sustained at 12-month follow-up (d = 0.94), and increases in quality of life from baseline to end-of-treatment (d = 0.83). Conclusions We demonstrate how DBT plus milieu residential care for young people continues to show positive effects in a 10-year comparison. However, youth seeking treatment today compared to 10 years ago evidenced higher acuity of psychiatric symptoms reinforcing the importance of continuous improvement of psychological treatments. Trial registration Australian New Zealand Clinical Trials Registry: trial IDACTRN12618000866202, retrospectively registered on 22/05/2018, .


2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Ikram I. Mohamed ◽  
Hossam Eddin Khalifa Ahmad ◽  
Shehab H. Hassaan ◽  
Shymaa M. Hassan

Sign in / Sign up

Export Citation Format

Share Document