scholarly journals Possible Association of Polymorphisms in Ubiquitin Specific Peptidase 46 Gene With Post-traumatic Stress Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Jun Ho Seo ◽  
Tae Yong Kim ◽  
Se Joo Kim ◽  
Jin Hee Choi ◽  
Hyung Seok So ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Ubiquitin Proteasome System ◽  
Combat Trauma ◽  
Post Traumatic Stress ◽  
Association Analyses ◽  
Single Marker ◽  
Ubiquitin Proteasome ◽  
Post Traumatic

Introduction: Dynamic proteolysis, through the ubiquitin-proteasome system, has an important role in DNA transcription and cell cycle, and is considered to modulate cell stress response and synaptic plasticity. We investigated whether genetic variants in the ubiquitin carboxyl-terminal hydrolase 46 (USP46) would be associated with post-traumatic stress disorder (PTSD) in people with exposure to combat trauma using a case-control candidate gene association design.Methods: Korean male veterans exposed to the Vietnam War were grouped into those with (n = 128) and without (n = 128) PTSD. Seven tagging SNPs of USP46 were selected, and single-marker and haplotype-based association analyses were performed. All analyses were adjusted for sociodemographic factors and levels of combat exposure severity and alcohol problem.Results: One single-marker (rs2244291) showed nominal evidence of association with PTSD status and with the “re-experiencing” cluster, although the association was not significant after Bonferroni correction. No significant association with the other SNPs or the haplotypes was detected.Conclusion: The present finding suggests preliminarily that genetic vulnerability regarding the ubiquitin-proteasome system may be related to fear memory processes and the development of PTSD symptoms after trauma exposure. Further studies with a larger sample size will be needed to examine the role of the ubiquitin-proteasome system including USP46 in PTSD.

scholarly journals Possible association of polymorphisms in ubiquitin specific peptidase 46 gene with post-traumatic stress disorder

2020 ◽  
Author(s):  
Jun-ho Seo ◽  
Tae-yong Kim ◽  
Se-joo Kim ◽  
Jin-hee Choi ◽  
Hyung-seok So ◽  
...  
Keyword(s):  
Vietnam War ◽  
Stress Disorder ◽  
Ubiquitin Proteasome System ◽  
Sociodemographic Factors ◽  
Combat Trauma ◽  
Post Traumatic Stress ◽  
Association Analyses ◽  
Male Veterans ◽  
Single Marker ◽  
Ubiquitin Proteasome

Abstract Background: Dynamic proteolysis, through the ubiquitin-proteasome system, has an important role in DNA transcription and cell cycle, and is considered to modulate cell stress response and synaptic plasticity. We investigated whether genetic variants in the ubiquitin carboxyl-terminal hydrolase 46 (USP46) would be associated with posttraumatic stress disorder (PTSD) in people with exposure to combat trauma using a case-control candidate gene association design. Methods: Korean male veterans exposed to the Vietnam War were grouped into those with (n = 128) and without (n = 128) PTSD. Seven tagging SNPs of USP46 were selected, and single-marker and haplotype-based association analyses were performed. All analyses were adjusted for sociodemographic factors and levels of combat exposure severity and alcohol problem. Results: One single-marker (rs2244291) showed nominal evidence of association with PTSD status and with the ‘re-experiencing’ cluster, although the association was not significant after Bonferroni correction. No significant association with the other SNPs or the haplotypes was detected. Conclusion: The present finding suggests preliminarily that genetic vulnerability regarding the ubiquitin-proteasome system may be related to fear memory processes and the development of PTSD symptoms after trauma exposure. Further studies with a larger sample size will be needed to examine the role of the ubiquitin-proteasome system including USP46 in PTSD.

scholarly journals Possible Association of Polymorphisms in Ubiquitin Specific Peptidase 46 Gene with Post-Traumatic Stress Disorder

2020 ◽  
Author(s):  
Jun-ho Seo ◽  
Tae-yong Kim ◽  
Se-joo Kim ◽  
Jin-hee Choi ◽  
Hyung-seok So ◽  
...  
Keyword(s):  
Vietnam War ◽  
Stress Disorder ◽  
Ubiquitin Proteasome System ◽  
Sociodemographic Factors ◽  
Combat Trauma ◽  
Post Traumatic Stress ◽  
Association Analyses ◽  
Male Veterans ◽  
Single Marker ◽  
Ubiquitin Proteasome

Abstract Background: Dynamic proteolysis, through the ubiquitin-proteasome system, has an important role in DNA transcription and cell cycle, and is considered to modulate cell stress response and synaptic plasticity. We investigated whether genetic variants in the ubiquitin carboxyl-terminal hydrolase 46 (USP46) would be associated with posttraumatic stress disorder (PTSD) in people with exposure to combat trauma using a case-control candidate gene association design. Methods: Korean male veterans exposed to the Vietnam War were grouped into those with (n = 128) and without (n = 128) PTSD. Seven tagging SNPs of USP46 were selected, and single-marker and haplotype-based association analyses were performed. All analyses were adjusted for sociodemographic factors and levels of combat exposure severity and alcohol problem. Results: One single-marker (rs2244291) showed nominal evidence of association with PTSD status and with the ‘re-experiencing’ cluster, although the association was not significant after Bonferroni correction. No significant association with the other SNPs or the haplotypes was detected. Conclusion: The present finding suggests preliminarily that genetic vulnerability regarding the ubiquitin-proteasome system may be related to fear memory processes and the development of PTSD symptoms after trauma exposure. Further studies with a larger sample size will be needed to examine the role of the ubiquitin-proteasome system including USP46 in PTSD.

scholarly journals Eye movement desensitisation and reprocessing

1999 ◽  
Vol 5 (2) ◽  
pp. 120-125 ◽  
Author(s):  
M. J. MacCulloch
Keyword(s):  
Eye Movements ◽  
Eye Movement ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Emotional Processing ◽  
Stress Disorder ◽  
Combat Trauma ◽  
Post Traumatic Stress ◽  
Long Period ◽  
Post Traumatic

Eye movement desensitisation and reprocessing (EMDR) was described by Shapiro (1989a,b) as a new method for treating post-traumatic stress disorder (PTSD). In May 1987, while walking in the park, Shapiro noticed that her own disturbing thoughts changed then disappeared “without any conscious effort” (Shapiro, 1995) when they had been temporally paired with diagonal upward to and fro eye movements. Over the next six months Shapiro worked with approximately 70 people to develop a procedure based on the temporal pairing of distressing images and thoughts with various eye movements. Shapiro began to develop strategies to unblock stalled emotional processing, which was initiated by EMDR in non-patients. She successfully tried the method on a Vietnam veteran suffering from severe PTSD and then embarked upon a trial of EMDR on a mixed group of victims of rape, molestation and Vietnam combat trauma. Initially, EMDR achieved wide recognition as a new breakthrough treatment for PTSD. This was, in part, because of very positive early reports (e.g. Wolpe & Abrams, 1991), but also because the EMDR effect appeared to occur with unprecedented speed, often in cases of PTSD that had previously resisted treatment by many other methods over a long period.

scholarly journals Review and Critical Evaluation of Cognitive Behavioural Therapy for the Treatment of Post-Traumatic Stress Disorder

2021 ◽  
Vol 9 (3) ◽  
pp. 56-64
Author(s):  
Azubuike Chidozie Precious
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Behavioral Therapy ◽  
Combat Trauma ◽  
Cognitive Behavioral ◽  
Post Traumatic Stress ◽  
Professional Literature ◽  
Post Traumatic

This systematic analysis seeks to describe the evidence regarding cognitive-behavioral therapy (CBT) for the treatment of post-traumatic stress disorder (PTSD) in the recent, published, professional literature. This systematic review addressed the question of the efficacy of and evidence for CBT for the treatment of PTSD. The review incorporates a comprehensive literature review, addresses the methodological quality of the papers, and synthesizes the results by themes. After evaluation of the published and professional literature, five themes; Result of CBT for PTSD, Alternatives to CBT for PTSD, CBT in practice, Treatment of children, and CBT in tandem with medication. 11 published studies including qualitative interviews, randomized control trials, and meta-analyses were examined. CBT proved to be instrumental in alleviating PTSD symptoms in men who have been exposed to combat trauma, women who have experienced violence, veterans who have gone through combat trauma and also have disorders due to addictions, and young adults and children who have experienced trauma. Studies have shown that CBT works quite well in the case of couples where one has been diagnosed with PTSD. CBT for PTSD can be delivered face-to-face or by using telepsychiatry. CBT tends to have a higher success rate when carried out while administering appropriate drugs. Also, carrying out CBT for PTSD can bring about stronger relationships and post-traumatic stress growth. Keywords: Cognitive Behavioral Therapy, Post-Traumatic Stress Disorder, Treatment.

Sign in / Sign up

Export Citation Format

Share Document