scholarly journals Controversy about the Role of Rifampin in Biofilm Infections: Is It Justified?

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 165
Author(s):  
Nora Renz ◽  
Andrej Trampuz ◽  
Werner Zimmerli
Keyword(s):  
Clinical Evidence ◽  
Controlled Trial ◽  
Joint Infection ◽  
Current Data ◽  
Multiple Drug ◽  
Randomized Controlled ◽  
The Past ◽  
Prosthesis Retention ◽  
Rifampin Resistance

Rifampin is a potent antibiotic against staphylococcal implant-associated infections. In the absence of implants, current data suggest against the use of rifampin combinations. In the past decades, abundant preclinical and clinical evidence has accumulated supporting its role in biofilm-related infections.In the present article, experimental data from animal models of foreign-body infections and clinical trials are reviewed. The risk for emergence of rifampin resistance and multiple drug interactions are emphasized. A recent randomized controlled trial (RCT) showing no beneficial effect of rifampin in patients with acute staphylococcal periprosthetic joint infection treated with prosthesis retention is critically reviewed and data interpreted. Given the existing strong evidence demonstrating the benefit of rifampin, the conduction of an adequately powered RCT with appropriate definitions and interventions would probably not comply with ethical standards.

scholarly journals Reconsidering Dexmedetomidine for Sedation in the Critically Ill: Implications of the SPICE III Trial

2019 ◽  
Vol 54 (5) ◽  
pp. 504-508
Author(s):  
Nicholas Farina ◽  
Cesar Alaniz
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Controlled Trial ◽  
First Line ◽  
Mechanically Ventilated ◽  
Randomized Controlled ◽  
The Past ◽  
Light Sedation ◽  
Care Evaluation

Dexmedetomidine is a sedative agent that has gained popularity for use in the intensive care unit over the past 20 years. Guidelines recommend dexmedetomidine as a first-line agent to achieve light sedation in mechanically ventilated adults. Recently, the SPICE III (Sedation Practice in Intensive Care Evaluation III) trial was published. This was a randomized controlled trial comparing initial sedation with dexmedetomidine with usual care sedation in adult patients receiving mechanical ventilation. The results of this trial have both validated and contradicted previous findings about dexmedetomidine. This editorial examines the merits of the SPICE III trial and the role of dexmedetomidine in practice following its publication.

Role of preoperative pregabalin in reducing inhalational anesthetic requirements in abdominal hysterectomy: randomized controlled trial

2020 ◽  
Vol 86 (1) ◽  
Author(s):  
Nesrine A. El-Refai ◽  
Jehan H. Shehata ◽  
Ahmed Lotfy ◽  
Ahmed M. Elbadawy ◽  
Reham A. Abdel Rahman ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Abdominal Hysterectomy ◽  
Randomized Controlled ◽  
Inhalational Anesthetic

Role of Chewing Gum in Reducing Postoperative Ileus after Reversal of Ileostomy: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Samiullah Bhatti ◽  
Yusra Jahangir Malik ◽  
Shabbar Hussain Changazi ◽  
Usman Ali Rahman ◽  
Awais Amjad Malik ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Postoperative Ileus ◽  
Controlled Trial ◽  
Chewing Gum ◽  
Randomized Controlled

What is the Role of the Bacterium Propionibacterium acnes in Type 1 Modic Changes? A Review of the Literature

2017 ◽  
Vol 68 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Mark Georgy ◽  
Mark Stern ◽  
Kieran Murphy
Keyword(s):  
Randomized Controlled Trial ◽  
Propionibacterium Acnes ◽  
Controlled Trial ◽  
Modic Changes ◽  
Low Back ◽  
Review Of The Literature ◽  
Disc Disease ◽  
Randomized Controlled

This review presents a summary of the pathology and epidemiology of Modic changes and the possible role of Propionibacterium acnes. This information is followed by a synthesis of the most recent clinical research involved in culturing the discs of patients with degenerative disc disease for the presence of bacteria. We also discuss a randomized controlled trial that investigates the effects of antibiotics on patients with chronic low back pain and type 1 Modic changes. We conclude with a brief discussion of the difficulties involved in this research and the significance of the findings.

scholarly journals Can SMS Technology Improve Low Take-up of Social Benefits?

2014 ◽  
Vol 20 (1) ◽  
pp. 61-81 ◽  
Author(s):  
Mariana Blanco ◽  
Juan F. Vargas
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Well Being ◽  
Social Benefits ◽  
Limited Evidence ◽  
Randomized Controlled ◽  
Potential Channels ◽  
Informational Barriers ◽  
Government Benefits

AbstractLow take-up of stigma-free social benefits is often blamed on information asymmetries or administrative barriers. There is limited evidence on which of these potential channels is more salient in which contexts. We designed and implemented a randomized controlled trial to assess the extent to which informational barriers are responsible for the prevalent low take-up of government benefits among Colombian conflict-driven internal refugees. We provide timely information on benefits eligibility via SMS to a random half of the displaced household that migrated to Bogotá over a 6-month period. We show that improving information increases benefits’ take-up. However, the effect is small and only true for certain type of benefits. Hence, consistent with previous experimental literature, the availability of timely information explains only part of the low take-up rates and the role of administrative barriers and bureaucratic processes should be tackled to increase the well-being of internal refugees in Colombia.

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