scholarly journals Nasal Decolonisation of MRSA

Antibiotics ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 14
Author(s):  
Peter Mantle
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Urinary Biomarker ◽  
Methicillin Resistant ◽  
Biomarker Of Exposure ◽  
Additional Resistance ◽  
Nasal Mupirocin ◽  
First Time ◽  
Recent Demonstration

The recent demonstration for the first time of urinary monic acid A as a clinical urinary biomarker of exposure to intra-nasal mupirocin during medication for methicillin-resistant Staphylococcus aureus (MRSA) offers a way of verifying adherence to the regimen. However, absence of the biomarker in some patients needs explanation, to ensure that efficient decolonisation has not been compromised by confounding circumstances, and that additional resistance to mupirocin has not unwittingly been encouraged.

Does Nasal Colonization or Mupirocin Treatment Affect Recurrence of Methicillin-Resistant Staphylococcus aureus Skin and Skin Structure Infections?

2007 ◽  
Vol 28 (12) ◽  
pp. 1415-1416 ◽  
Author(s):  
Joseph Rahimian ◽  
Raymond Khan ◽  
Keith A. LaScalea
Keyword(s):  
Staphylococcus Aureus ◽  
Retrospective Study ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Nasal Colonization ◽  
Methicillin Resistant ◽  
Skin Structure ◽  
Nasal Mupirocin

Some patients with community-associated methicillin-resistant Staphylococcus aureus skin and skin structure infections have experienced frequent recurrences. We performed a retrospective study and determined that the presence of nasal colonization did not affect recurrence and nasal mupirocin treatment marginally decreased recurrence

scholarly journals Formyl-Peptide Receptor Activation Enhances Phagocytosis of Community-Acquired Methicillin-Resistant Staphylococcus aureus

2019 ◽  
Author(s):  
Elisabeth Weiß ◽  
Katja Schlatterer ◽  
Christian Beck ◽  
Andreas Peschel ◽  
Dorothee Kretschmer
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Receptor Activation ◽  
Formyl Peptide Receptor ◽  
Peptide Receptors ◽  
Highly Pathogenic ◽  
Methicillin Resistant ◽  
Formyl Peptide Receptors ◽  
Formyl Peptide ◽  
First Time

Abstract Background Formyl-peptide receptors (FPRs) are important pattern recognition receptors that sense specific bacterial peptides. Formyl-peptide receptors are highly expressed on neutrophils and monocytes, and their activation promotes the migration of phagocytes to sites of infection. It is currently unknown whether FPRs may also influence subsequent processes such as bacterial phagocytosis and killing. Staphylococcus aureus, especially highly pathogenic community-acquired methicillin-resistant S aureus strains, release high amounts of FPR2 ligands, the phenol-soluble modulins. Methods We demonstrate that FPR activation leads to upregulation of complement receptors 1 and 3 as well as FCγ receptor I on neutrophils and, consequently, increased opsonic phagocytosis of S aureus and other pathogens. Results Increased phagocytosis promotes killing of S aureus and interleukin-8 release by neutrophils. Conclusions We show here for the first time that FPRs govern opsonic phagocytosis. Manipulation of FPR2 activation could open new therapeutic opportunities against bacterial pathogens.

scholarly journals Prospective Investigation of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Community-Associated Methicillin-Resistant Staphylococcus aureus Infections

2011 ◽  
Vol 56 (2) ◽  
pp. 1084-1086 ◽  
Author(s):  
Loren G. Miller ◽  
Jennifer Tan ◽  
Samantha J. Eells ◽  
Esther Benitez ◽  
Allen B. Radner
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Skin Infections ◽  
Methicillin Resistant ◽  
Content Type ◽  
Nasal Mupirocin ◽  
The Mean ◽  
Systemic Antibiotics ◽  
Prospective Investigation

ABSTRACTRecurrent community-associated methicillin-resistantStaphylococcus aureus(CA-MRSA) skin infections are an increasingly common problem. However, there are no data on the efficacy of decolonization regimens. We prospectively evaluated 31 patients with recurrent CA-MRSA skin infections who received nasal mupirocin, topical hexachlorophene body wash, and an oral anti-MRSA antibiotic. The mean number of MRSA infections after the intervention decreased significantly from baseline (0.03 versus 0.84 infections/month,P= <0.0001). This regimen appears promising at preventing recurrent CA-MRSA infections.

scholarly journals A Novel Staphylococcal Cassette ChromosomemecType XI Primer for Detection ofmecC-Harboring Methicillin-Resistant Staphylococcus aureus Directly from Screening Specimens

2015 ◽  
Vol 53 (12) ◽  
pp. 3938-3941 ◽  
Author(s):  
Sabine Petersdorf ◽  
Miriam Herma ◽  
Meike Rosenblatt ◽  
Franziska Layer ◽  
Birgit Henrich
Keyword(s):  
Staphylococcus Aureus ◽  
Real Time ◽  
Real Time Pcr ◽  
Rapid Detection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Content Type ◽  
First Time ◽  
Staphylococcal Cassette Chromosome

Methicillin-resistantStaphylococcus aureus(MRSA) screening using real-time PCR has decreased in sensitivity due to the emergence of variant staphylococcal cassette chromosomemecelement (SCCmec) types. We have designed and validated a novel SCCmecXI primer, which enables for the first time the rapid detection ofmecC-harboring MRSA directly from nasopharyngeal swabs without prior cultivation.

Identification of methicillin-resistant Staphylococcus aureus carrying an exfoliative toxin A gene encoding phage isolated from a hospitalized patient in Turkey

2013 ◽  
Vol 59 (4) ◽  
pp. 260-265
Author(s):  
Fikret Sahin ◽  
Djursun Karasartova ◽  
T. Murat Özsan ◽  
Mehmet Kiyan ◽  
Ceren Z. Karahan ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Fragment Length Polymorphism ◽  
Rflp Analysis ◽  
Polymorphic Variation ◽  
Gene Encoding ◽  
Methicillin Resistant ◽  
Causative Agents ◽  
Mrsa Strains ◽  
First Time

From the four known isoforms of the staphylococcal exfoliative toxins (ETs), only ETA and ETB are the major causative agents. General knowledge is that the gene for ETA is located on the chromosome, whereas that for ETB is located on a large plasmid. Yoshizawa and co-workers (2000, Microbiol. Immunol. 44(3): 189–191) isolated, for the first time, a temperate phage (φETA) that carried the structural gene for ETA from an ETA-producing strain of Staphylococcus aureus. In this study, we presented eta gene encoding temperate phages isolated from methicillin-resistant S.aureus (MRSA) isolates obtained from patients in a Turkish hospital. Molecular analysis of the phage genome revealed that the eta gene is located upstream to amidase and holin genes, the same as in the φETA genome. However, partial sequence analysis of amidase and holin genes revealed polymorphic variation. In addition to polymorphic variation, restriction fragment length polymorphism (RFLP) analysis of all of the phage genomes showed that the ETA-containing phage is different from the rest of the phage genomes. The phylogenetic dendrogram of pulsed field gel electrophoresis (PFGE) analysis showed that the ETA-carrying MRSA is quite different from the rest of the MRSA strains. This is the first report showing that a MRSA strain carries an ETA-encoding phage.

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