scholarly journals Bioresorption Control and Biological Response of Magnesium Alloy AZ31 Coated with Poly-β-Hydroxybutyrate

2021 ◽  
Vol 11 (12) ◽  
pp. 5627
Author(s):  
Lu Wang ◽  
Raffaella Aversa ◽  
Zhengjun Houa ◽  
Jie Tian ◽  
Shuang Liang ◽  
...  

Magnesium and its alloys are not normally used as bioresorbable temporary implants due to their high and uncontrolled degradation rate in a physiological liquid environment. The improvement of corrosion resistance to simulated body fluids (SBF) of a magnesium alloy (AZ31) coated with poly-β-hydroxybutyrate (PHB) was investigated. Scanning electron microscopy, Fourier transform infrared spectrometer, and contact angle measurements were used to characterize surface morphology, material composition, and wettability, respectively. pH modification of the SBF corroding medium, mass of Mg2+ ions released, weight loss of the samples exposed to the SBF solution, and electrochemical experiments were used to describe the corrosion process and its kinetics. The material’s biocompatibility was described by evaluating the effect of corrosion by products collected in the SBF equilibrating solution on hemolysis ratio, cytotoxicity, nitric oxide (NO), and total antioxidant capacity (T-AOC). The results showed that the PHB coating can diffusively control the degradation rate of magnesium alloy, improving its biocompatibility: the hemolysis rate of materials was lower than 5%, while in vitro human umbilical vein endothelial cell (HUVEC) compatibility experiments showed that PHB-coated Mg alloy promoted cell proliferation and had no effect on the NO content and that the T-AOC was enhanced compared with the normal group and bare AZ31 alloy. PHB-coated AZ31 magnesium alloy extraction fluids have a less toxic behavior due to the lower concentration of corrosion byproducts deriving from the diffusion control exerted by the PHB coating films both from the metal surface to the solution and vice versa. These findings provide more reference value for the selection of such systems as tunable bioresorbable prosthetic materials.

Author(s):  
Lu Wang ◽  
Zhengjun Hou ◽  
Jie Tian ◽  
Shuang Liang ◽  
Shuping Ge ◽  
...  

Magnesium and its alloys are not normally used as bio-resorbable temporary implants due to their high and uncontrolled degradation rate in physiological liquid environment. The improvement of corrosion resistance to simulated body fluids (SBF) of a Magnesium alloy (AZ31) coated with poly-β-hydroxybutyrate (PHB) was investigated. Scanning electron microscopy, Fourier transform infrared spectrometer, and contact angle measurements were used to characterize surface morphology, material composition and wettability, respectively. pH modification of the SBF corroding medium, mass of Mg2+ ions released, and weight loss of the samples exposed to the SBF solution, and electrochemical experiment were used to describe the corrosion process and its kinetics. Materials biocompatibility was described by evaluating the effect of corrosion by products collected in the SBF equilibrating solution on hemolysis ratio, cytotoxicity, Nitric Oxide (NO), and total antioxidant capacity (T-AOC). The results showed that the PHB coating can diffusively control the degradation rate of Magnesium alloy improving its biocompatibility: hemolysis rate of materials was lower than 5%, while in vitro Human Umbilical Vein Endothelial Cells(HUVECs) compatibility experiments showed that PHB coated Mg alloy promoted cell proliferation and had no effect on the NO content, the T-AOC was enhanced compared with the normal group and bare AZ31 alloy. PHB coated AZ31 Magnesium alloy extraction fluids have a less toxic behavior due to the lower concentration of corrosion by-products deriving from the diffusion control exerted by the PHB coating films both from metal surface to the solution and vice versa. These findings provide more reference value for the selection of such system as tunable bioresorbable prosthetic materials


2020 ◽  
Vol 5 (1) ◽  
pp. 153-163 ◽  
Author(s):  
Lan-Yue Cui ◽  
Shen-Cong Cheng ◽  
Lu-Xian Liang ◽  
Jing-Chao Zhang ◽  
Shuo-Qi Li ◽  
...  

2020 ◽  
Vol 5 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Chang-Yang Li ◽  
Chi Yu ◽  
Rong-Chang Zeng ◽  
Bo-Cheng Zhang ◽  
Lan-Yue Cui ◽  
...  

2020 ◽  
Vol 5 (2) ◽  
pp. 364-376 ◽  
Author(s):  
Chang-Yang Li ◽  
Ling Gao ◽  
Xiao-Li Fan ◽  
Rong-Chang Zeng ◽  
Dong-Chu Chen ◽  
...  

2020 ◽  
Vol 47 ◽  
pp. 52-67 ◽  
Author(s):  
Jian Wang ◽  
Lanyue Cui ◽  
Yande Ren ◽  
Yuhong Zou ◽  
Jinlong Ma ◽  
...  

2018 ◽  
Vol 12 (2) ◽  
pp. 184-197 ◽  
Author(s):  
Ling-Yu Li ◽  
Bin Liu ◽  
Rong-Chang Zeng ◽  
Shuo-Qi Li ◽  
Fen Zhang ◽  
...  

2014 ◽  
Vol 9 (2) ◽  
pp. 249-257
Author(s):  
Chuanxing Li ◽  
Yanling Zhang ◽  
Dong Chen ◽  
Guangfeng Duan ◽  
Zhenyin Liu ◽  
...  

2021 ◽  
Vol 807 ◽  
pp. 140821
Author(s):  
Kai Zhang ◽  
Zhutao Shao ◽  
Christopher S. Daniel ◽  
Mark Turski ◽  
Catalin Pruncu ◽  
...  

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