scholarly journals Use of Continuous Positive Airway Pressure (CPAP) to Limit Diaphragm Motion—A Novel Approach for Definitive Radiation Therapy for Inoperable Pleural Mesothelioma: A Pilot Study

Biology ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 711
Author(s):  
Assaf Moore ◽  
Marc J. Kindler ◽  
Aaron Max Allen
Keyword(s):  
Pilot Study ◽  
Static Field ◽  
Normal Lung ◽  
Pleural Mesothelioma ◽  
Lung Dose ◽  
Lung Inflation ◽  
Novel Approach ◽  
Recent Developments ◽  
Ct Simulation ◽  
Dose Constraints

Malignant pleural mesothelioma (MPM) is a deadly disease and radiotherapy (RT) plays an important role in its management. Recent developments in technique have made it is possible to deliver RT to MPM in the intact lung. However, it is imperative to reduce normal lung doses. We present a pilot study examining the use of CPAP and VMAT radiotherapy to reduce toxicity when treating MPM, involving three consecutive patients with MPM, not amenable to surgery, who were treated according to Helsinki committee approval. Patients were simulated using four-dimentional CT simulation with the assistance of CPAP lung inflation, then were treated using both IMRT and VMAT techniques. Radiation lung dose was optimized based on accepted lung dose constraints. Patients were followed for toxicity as well as local control and survival. Results: Three patients were treated with CPAP-based IMRT treatment. These patients tolerated the treatment and DVH constraints were able to be met. The comparison plans among the four VMAT arcs and the IMRT static field treatment were able to accomplish the treatment planning objectives without significant advantages with either technique. The treatment combined with CPAP reduced the normal lung dose in MPM patients with intact lungs. This technique is worthy of further investigation.

The Impact on PTVs and Normal Lung Dose of Using 18F-FDF PET/CT Simulation on an Already PET/CT Staged Cohort of NSCLC Patients

2010 ◽  
Vol 78 (3) ◽  
pp. S523-S524
Author(s):  
A. Hounsell ◽  
G.G. Hanna ◽  
K.J. Carson ◽  
J. McAleese ◽  
V.P. Cosgrove ◽  
...  
Keyword(s):  
Normal Lung ◽  
Lung Dose ◽  
Pet Ct ◽  
Ct Simulation ◽  
Nsclc Patients ◽  
The Impact

scholarly journals Tissue adhesive—A novel approach to the securement of intra-arterial catheters? A randomised controlled pilot study

2014 ◽  
Vol 27 (1) ◽  
pp. 57
Author(s):  
M. Edwards ◽  
C. Rickard ◽  
I. Rapchuk ◽  
A. Corley ◽  
N. Marsh ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tissue Adhesive ◽  
Novel Approach ◽  
Randomised Controlled

Banding Without Resection (Endoscopic Mucosal Ligation) as a Novel Approach for the Ablation of Short-Segment Barrett's Epithelium: Results of a Pilot Study

2007 ◽  
Vol 102 (8) ◽  
pp. 1640-1645 ◽  
Author(s):  
Edgardo Diaz-Cervantes ◽  
Antonio De-la-Torre-Bravo ◽  
Stuart Jon Spechler ◽  
Ernesto Torres-Durazo ◽  
Sergio Sobrino-Cossio ◽  
...  
Keyword(s):  
Pilot Study ◽  
Short Segment ◽  
Barrett’S Epithelium ◽  
Novel Approach ◽  
Barrett's Epithelium

A Novel Approach to Penile Augmentation Urethroplasty Using Buccal Mucosa and Amniotic Membrane: A Pilot Study in a Rabbit Model

Urology ◽  
2016 ◽  
Vol 87 ◽  
pp. 210-215 ◽  
Author(s):  
Mustafa Güneş ◽  
Muammer Altok ◽  
Alime Güneş ◽  
Mehmet Umul ◽  
Zafer Özyıldız ◽  
...  
Keyword(s):  
Pilot Study ◽  
Amniotic Membrane ◽  
Buccal Mucosa ◽  
Rabbit Model ◽  
Novel Approach

Aspects of Various Community Detection Algorithms in Social Network Analysis

2019 ◽  
pp. 327-341
Author(s):  
Nicole Belinda Dillen ◽  
Aruna Chakraborty
Keyword(s):  
Social Network ◽  
Social Network Analysis ◽  
Network Analysis ◽  
Community Detection ◽  
Overlapping Community Detection ◽  
Detection Algorithms ◽  
Novel Approach ◽  
Recent Developments ◽  
Overlapping Community ◽  
Related Individuals

One of the most important aspects of social network analysis is community detection, which is used to categorize related individuals in a social network into groups or communities. The approach is quite similar to graph partitioning, and in fact, most detection algorithms rely on concepts from graph theory and sociology. The aim of this chapter is to aid a novice in the field of community detection by providing a wider perspective on some of the different detection algorithms available, including the more recent developments in this field. Five popular algorithms have been studied and explained, and a recent novel approach that was proposed by the authors has also been included. The chapter concludes by highlighting areas suitable for further research, specifically targeting overlapping community detection algorithms.

In situ fabrication of PAN nanofibrous composites for enhanced toughness

2020 ◽  
Vol 234 (16) ◽  
pp. 3228-3240
Author(s):  
A Zarehshi ◽  
AA Gharehaghaji ◽  
AA Asgharian Jeddi
Keyword(s):  
Fracture Toughness ◽  
Conventional Method ◽  
Polymeric Fibers ◽  
Elongation At Break ◽  
In Situ Fabrication ◽  
In Situ Method ◽  
Novel Approach ◽  
Polymeric Nanofibers ◽  
Recent Developments

Recent developments in nanocomposites that are reinforced with polymeric fibers have heightened the need for a material in fast-moving parts of machines. The research to date has focused on tensile properties of nanocomposites reinforced with polymeric nanofibers, which were produced by the conventional methods. In this work, nanocomposites were fabricated by a novel approach that comprises epoxy resin, epoxy hardener, and PAN nanofibers in which the nanofibrous layer was placed in resin as spun during the electrospinning. Then, a nanocomposite with the same materials was made using the conventional method of layering. There were enhancements in elongation at break, fracture toughness, and stress at break of nanocomposites fabricated by in situ method in comparison with the nanocomposites fabricated using the conventional method of layering.

scholarly journals Intensity-Modulated Radiation Therapy Optimization for Acceptable and Remaining-One Unacceptable Dose-Volume and Mean-Dose Constraint Planning

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Ryosei Nakada ◽  
Omar M. Abou Al-Ola ◽  
Tetsuya Yoshinaga
Keyword(s):  
Radiation Therapy ◽  
Planning Process ◽  
Intensity Modulated Radiation Therapy ◽  
Optimal Solution ◽  
Intensity Modulated ◽  
Novel Approach ◽  
Dose Volume ◽  
Dose Constraint ◽  
Imrt Planning ◽  
Dose Constraints

We give a novel approach for obtaining an intensity-modulated radiation therapy (IMRT) optimization solution based on the idea of continuous dynamical methods. The proposed method, which is an iterative algorithm derived from the discretization of a continuous-time dynamical system, can handle not only dose-volume but also mean-dose constraints directly in IMRT treatment planning. A theoretical proof for the convergence to an equilibrium corresponding to the desired IMRT planning is given by using the Lyapunov stability theorem. By introducing the concept of “acceptable,” which means the existence of a nonempty set of beam weights satisfying the given dose-volume and mean-dose constraints, and by using the proposed method for an acceptable IMRT planning, one can resolve the issue that the objective and evaluation are different in the conventional planning process. Moreover, in the case where the target planning is totally unacceptable and partly acceptable except for one group of dose constraints, we give a procedure that enables us to obtain a nearly optimal solution close to the desired solution for unacceptable planning. The performance of the proposed approach for an acceptable or unacceptable planning is confirmed through numerical experiments simulating a clinical setup.

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