Abstract
BackgroundThe aim of this study was to evaluate the dose distribution, and also tumor control probability (TCP) and normal tissue complications probability (NTCP) models of left sided breast cancer females for 3D-CRT, 6 and 9 fields IMRT and hypofractionated tangential plans.MethodsSixty left sided breast cancer females were included in this study. CT simulation images of the patients were imported on the treatment planning software (TiGRT, LinaTech, China), and the tangential treatment plans of the mentioned methods were done for each patient. The dosimetric evaluation, and TCP-NTCP models of stated modalities were done using Poisson Linear-Quadatric (PLQ) and Lyman-Kutcher-Burman (LKB) models on the MATLAB and R softwares.ResultsThe mean (± SD) dose to ipsilateral lung, heart, LAD and RCA with/without internal mammary fields for 6FIMRT was lower compared to other modalities. Furthermore, V20Gy for Ipsilateral lung and V25Gy for heart, LAD and RCA of 6FIMRT was lower than other methods. In addition, the PTV dose coverage was higher for 9FIMRT and hypofractionated RT, while it may be lower for 3D-CRT among the studied methods. Although TCP values of 9 and 6fieds and hypofractionated was not significantly different, the TCPs of them were higher compared to 3D-CRT. However, the NTCP for ipsilateral lung, heart, LAD and RCA of 6FIMRT was lower than others.Conclusion6FIMRT is suitable choice for RT of breast cancer patients compared to other mentioned modalities, as a result of providing adequate PTV dose coverage and TCP, and also lower imposed dose and NTCP for OARs. Hypofractionated RT is a good alternative to reduce treatment time for the breast cancer patients.Trial registrationThis study was approved by the ethical board of Isfahan University of Medical Sciences, Isfahan, Iran (IR.MUI.MED.REC.1399.677).