The Relationship between Occupationally Exposed Arsenic, Cadmium and Lead and Brain Bioelectrical Activity—A Visual and Brainstem Auditory Evoked Potentials Study

The aim of this study was to evaluate the parameters of visual and brainstem auditory evoked potentials in patients occupationally exposed to arsenic, cadmium and lead. The study group comprised 41 copper smelter and refinery workers (average age: 51.27) with occupational exposure to arsenic, cadmium and lead. The control group consisted of 36 healthy volunteers (35 men and 1 woman, aged 27–66, average age: 51.08). Neurological examination, brain imaging, and visual and brainstem auditory evoked potentials were performed, and the relationship between blood Cd, Pb concentration (Cd-B, Pb-B), blood zinc protoporphyrin (ZnPP), and urine As concentration (As-U) were assessed. In the workers, exceedances of allowable biological concentrations were observed, with the urinary concentration of arsenic being 5.2%, the cadmium and lead in blood being 1.3%, while the case of ZnPP was 2.6%. The mean P100, relative P100, and N145 visual evoked potential (VEP) latencies were significantly longer in exposed workers than in the controls. The mean wave III and V brainstem auditory evoked potential (BAEP) latency and the mean wave III–V and I–V interpeak latencies were longer, and the I and V amplitude was lower in the workers than the controls. In summary, occupational exposure to As, Cd, and Pb is associated with prolonged latency and reduced evoked potential amplitude, but As-U, Pb-B, Cd-B, and ZnPP concentrations are not linearly related to potential components. The analysis of evoked potentials may be a useful method of assessment of the central nervous system in patients with occupational exposure to heavy metals.

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Effects of occupational exposure to mercury and lead on brainstem auditory evoked potentials

International Journal of Psychophysiology ◽

10.1016/0167-8760(93)90080-9 ◽

1993 ◽

Vol 14 (1) ◽

pp. 21-25 ◽

Cited By ~ 31

Author(s):

Gianluigi Discalzi ◽

Donatella Fabbro ◽

Fabrizio Meliga ◽

Alberto Mocellini ◽

Franco Capellaro

Keyword(s):

Occupational Exposure ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Brainstem Auditory Evoked Potentials ◽

Occupational Exposure To Mercury

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Assessment of Visual and Brainstem Auditory Evoked Potentials in Patients with Hashimoto’s Thyroiditis

Journal of Immunology Research ◽

10.1155/2021/3258942 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Marta Waliszewska-Prosół ◽

Maria Ejma

Keyword(s):

Nervous System ◽

Evoked Potentials ◽

Neurological Examination ◽

Hashimoto’S Thyroiditis ◽

Auditory Evoked Potentials ◽

Hashimoto's Thyroiditis ◽

Bioelectrical Activity ◽

Brainstem Auditory Evoked Potentials ◽

System Involvement ◽

The Mean

Background. The present study was aimed to evaluate parameters of visual and brainstem auditory evoked potentials (VEP, BAEP) in euthyreotic Hashimoto’s thyroiditis (HT) patients without central nervous system involvement. Methods. 100 HT patients (92 women, 8 men), mean age 46.9 years, and 50 healthy controls. They underwent a neurological examination, thyroid hormone levels, thyroid autoantibody titers, and brain imaging. Latencies and amplitudes of the N75, P100, and N145 component of VEP and the I-V components of BAEP were analyzed. Results. The neurological examination revealed in 31 patients signs of increased neurovegetative excitability. Brain resonance imaging showed no abnormalities in HT patients. The mean P100, relative P100, and N145 VEP latencies were significantly longer, and P100 amplitude significantly higher in HT patients than the controls. HT patients also had a longer mean wave BAEP V latency and mean wave III-V and I-V interpeak latencies, and significantly lower mean wave I and V amplitudes. Abnormal VEP and BAEP were recorded in 34% of the patients. There were no statistically significant correlations between the mean VEP parameters and thyroid profile and the applied dose of L-thyroxine. There was a relationship between the level of TSH and the wave BAEP III-V interpeak latency. Conclusions. There were changes in the brain’s bioelectrical activity in one-third of the patients with HT without nervous system involvement. The increased amplitude of the VEP may indicate increased cerebral cortex activity. Disorders of the brain’s bioelectrical activity in the course of HT may be associated with an autoimmune process.

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Brainstem auditory evoked potentials in horses

Ciência Rural ◽

10.1590/0103-8478cr20141716 ◽

2016 ◽

Vol 46 (4) ◽

pp. 681-685

Author(s):

Juliana Almeida Nogueira da Gama ◽

Mariana Isa Poci Palumbo ◽

Giovane Olivo ◽

Nadia Crosignani Outeda ◽

Luiz Antônio de Lima Resende ◽

...

Keyword(s):

Normative Data ◽

Auditory Evoked Potentials ◽

Evoked Potential ◽

Auditory Evoked Potential ◽

Brainstem Auditory Evoked Potentials ◽

Auditory Pathways ◽

Noise Masking ◽

Clinically Normal ◽

The Mean ◽

The Waves

ABSTRACT: The brainstem auditory evoked potential (BAEP) evaluates the integrity of the auditory pathways to the brainstem. The aim of this study was to evoke BAEPs in 21 clinically normal horses. The animals were sedated with detomidine hydrochloride (0.013mg.kg-1 BW). Earphones were inserted and rarefaction clicks at 90 dB and noise masking at 40 dB were used. After performing the test, the latencies of waves (I, II, III, IV, and V) and interpeaks(I-III, III-V, and I-V) were identified. The mean latencies of the waves were as follows: wave I, 2.4 ms; wave II, 2.24 ms; wave III, 3.61ms; wave IV, 4.61ms; and wave V, 5.49ms. The mean latencies of the interpeaks were as follows: I-III, 1.37ms; III-V, 1.88ms; and I-V, 3.26ms. This is the first study using BAEPs in horses in Brazil, and the observed latencies will be used as normative data for the interpretation of tests performed on horses with changes related to auditory system or neurologic abnormalities.

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