scholarly journals Audiovisual Lexical Retrieval Deficits Following Left Hemisphere Stroke

2018 ◽  
Vol 8 (12) ◽  
pp. 206 ◽  
Author(s):  
Brenda Hanna-Pladdy ◽  
Hyun Choi ◽  
Brian Herman ◽  
Spenser Haffey
Keyword(s):  
Left Hemisphere ◽  
Temporal Lobe ◽  
Multisensory Processing ◽  
Reaction Times ◽  
Semantic Integration ◽  
Lexical Retrieval ◽  
Confrontation Naming ◽  
Lower Accuracy ◽  
Modality Specificity ◽  
Left Hemisphere Stroke

Binding sensory features of multiple modalities of what we hear and see allows formation of a coherent percept to access semantics. Previous work on object naming has focused on visual confrontation naming with limited research in nonverbal auditory or multisensory processing. To investigate neural substrates and sensory effects of lexical retrieval, we evaluated healthy adults (n = 118) and left hemisphere stroke patients (LHD, n = 42) in naming manipulable objects across auditory (sound), visual (picture), and multisensory (audiovisual) conditions. LHD patients were divided into cortical, cortical–subcortical, or subcortical lesions (CO, CO–SC, SC), and specific lesion location investigated in a predictive model. Subjects produced lower accuracy in auditory naming relative to other conditions. Controls demonstrated greater naming accuracy and faster reaction times across all conditions compared to LHD patients. Naming across conditions was most severely impaired in CO patients. Both auditory and visual naming accuracy were impacted by temporal lobe involvement, although auditory naming was sensitive to lesions extending subcortically. Only controls demonstrated significant improvement over visual naming with the addition of auditory cues (i.e., multisensory condition). Results support overlapping neural networks for visual and auditory modalities related to semantic integration in lexical retrieval and temporal lobe involvement, while multisensory integration was impacted by both occipital and temporal lobe lesion involvement. The findings support modality specificity in naming and suggest that auditory naming is mediated by a distributed cortical–subcortical network overlapping with networks mediating spatiotemporal aspects of skilled movements producing sound.

scholarly journals Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Frank E Garcea ◽  
Clint Greene ◽  
Scott T Grafton ◽  
Laurel J Buxbaum
Keyword(s):  
Left Hemisphere ◽  
Temporal Lobe ◽  
Tool Use ◽  
Critical Issue ◽  
Inferior Parietal Lobule ◽  
Sensory Motor ◽  
Limb Apraxia ◽  
Parietal Lobule ◽  
Skilled Action ◽  
Left Hemisphere Stroke

Abstract Producing a tool use gesture is a complex process drawing upon the integration of stored knowledge of tools and their associated actions with sensory–motor mechanisms supporting the planning and control of hand and arm actions. Understanding how sensory–motor systems in parietal cortex interface with semantic representations of actions and objects in the temporal lobe remains a critical issue and is hypothesized to be a key determinant of the severity of limb apraxia, a deficit in producing skilled action after left hemisphere stroke. We used voxel-based and connectome-based lesion-symptom mapping with data from 57 left hemisphere stroke participants to assess the lesion sites and structural disconnection patterns associated with poor tool use gesturing. We found that structural disconnection among the left inferior parietal lobule, lateral and ventral temporal cortices, and middle and superior frontal gyri predicted the severity of tool use gesturing performance. Control analyses demonstrated that reductions in right-hand grip strength were associated with motor system disconnection, largely bypassing regions supporting tool use gesturing. Our findings provide evidence that limb apraxia may arise, in part, from a disconnection between conceptual representations in the temporal lobe and mechanisms enabling skilled action production in the inferior parietal lobule.

scholarly journals Structural Disconnection of the Tool Use Network After Left Hemisphere Stroke Predicts Limb Apraxia Severity

2020 ◽  
Author(s):  
Frank E. Garcea ◽  
Clint Greene ◽  
Scott T. Grafton ◽  
Laurel J. Buxbaum
Keyword(s):  
Left Hemisphere ◽  
Temporal Lobe ◽  
Tool Use ◽  
Temporal Cortex ◽  
Inferior Parietal Lobule ◽  
Sensory Motor ◽  
Limb Apraxia ◽  
Parietal Lobule ◽  
Skilled Action ◽  
Left Hemisphere Stroke

AbstractProducing a tool use gesture is a complex process drawing upon the integration of stored knowledge of tools and their associated actions with sensory-motor mechanisms supporting the planning and control of hand and arm actions. Understanding how sensory-motor systems in parietal cortex interface with semantic representations of actions and objects in the temporal lobe remains a critical issue, and is hypothesized to be a key determinant of the severity of limb apraxia, a deficit in producing skilled action after left hemisphere stroke. We used voxel-based and connectome-based lesion symptom mapping with data from 57 left hemisphere stroke participants to assess the lesion sites and structural disconnection patterns associated with poor tool use gesturing. We found that structural disconnection between the left inferior parietal lobule, lateral temporal lobe (left middle temporal gyrus) and ventral temporal cortex (left medial fusiform gyrus) predicted the severity of tool use gesturing performance. Control analyses demonstrated that reductions in right-hand grip strength were associated with motor system disconnection, bypassing regions supporting tool use gesturing. Our findings provide causal evidence that limb apraxia may arise, in part, from disconnection of conceptual representations in the temporal lobe from mechanisms enabling skilled action production in the inferior parietal lobule.

Praxis Lateralization: Errors in Right and Left Hemisphere Stroke

Cortex ◽  
2001 ◽  
Vol 37 (2) ◽  
pp. 219-230 ◽  
Author(s):  
Brenda Hanna-Pladdy ◽  
Stephanie K. Daniels ◽  
Melanie A. Fieselman ◽  
Kenneth Thompson ◽  
Jennifer J. Vasterling ◽  
...  
Keyword(s):  
Left Hemisphere ◽  
Left Hemisphere Stroke

scholarly journals Phonotactic processing deficit following left-hemisphere stroke

Cortex ◽  
2018 ◽  
Vol 99 ◽  
pp. 346-357 ◽  
Author(s):  
Maryam Ghaleh ◽  
Laura M. Skipper-Kallal ◽  
Shihui Xing ◽  
Elizabeth Lacey ◽  
Iain DeWitt ◽  
...  
Keyword(s):  
Left Hemisphere ◽  
Processing Deficit ◽  
Left Hemisphere Stroke

scholarly journals Strong conceptual ability reduces the effect of lexical impairments on verb retrieval in aphasia

2021 ◽  
Author(s):  
Haley C. Dresang ◽  
William D. Hula ◽  
Tessa Warren ◽  
Michael Walsh Dickey
Keyword(s):  
Left Hemisphere ◽  
Language Processing ◽  
Brain Injuries ◽  
Conceptual Processing ◽  
Action Processing ◽  
Processing Abilities ◽  
Conceptual Ability ◽  
Chronic Aphasia ◽  
Left Hemisphere Stroke ◽  
Open Question

Verb-retrieval impairments are pervasive deficits that can negatively impact communicative function for individuals living with aphasia. Unfortunately, the neurocognitive basis of these deficits remains poorly understood. One open question is the degree to which verb-retrieval impairments might be rooted in lexical- versus conceptual-processing deficits. These deficits can be co-present and correlated in people with aphasia, but they have also been found to be dissociated in patients with a variety of acquired brain injuries. This study examined the degree to which conceptual versus lexical action-processing abilities are impaired and may contribute to verb-retrieval impairments in adults with chronic aphasia due to left-hemisphere stroke. The results indicate that conceptual action processing can be impaired in aphasia and may contribute to verb-retrieval impairments. Furthermore, relatively unimpaired conceptual processing can ameliorate the influence of lexical impairments on verb-retrieval impairments. These findings are consistent with models in which conceptual representations play a key role in language processing and may be leveraged to improve verb retrieval in adults with chronic aphasia.

Right hemisphere speech perception revealed by amobarbital injection and electrical interference

Neurology ◽  
1998 ◽  
Vol 51 (2) ◽  
pp. 458-464 ◽  
Author(s):  
D. Boatman ◽  
J. Hart ◽  
R. P. Lesser ◽  
N. Honeycutt ◽  
N. B. Anderson ◽  
...  
Keyword(s):  
Speech Perception ◽  
Left Hemisphere ◽  
Temporal Lobe ◽  
Right Hemisphere ◽  
Adult Brain ◽  
Left Posterior ◽  
Left And Right ◽  
Sodium Amobarbital ◽  
The Right ◽  
Electrical Interference

Objective: To investigate the right hemispheric speech perception capabilities of an adult right-handed patient with seizures.Methods: Consecutive, unilateral, intracarotid sodium amobarbital injections and left hemispheric electrical interference mapping were used to determine lateralization and localization of speech perception, measured as syllable discrimination.Results: Syllable discrimination remained intact after left and right intracarotid sodium amobarbital injections. Language otherwise strongly lateralized to the left hemisphere. Despite evidence of bilateral speech perception capabilities, electrical interference testing in the left posterior temporal lobe impaired syllable discrimination.Conclusions: The results suggest a functionally symmetric, parallel system in the adult brain with preferential use of left hemispheric pathways for speech perception.

scholarly journals Regional Shape Abnormalities in Thalamus and Verbal Memory Impairment After Subcortical Infarction

2019 ◽  
Vol 33 (6) ◽  
pp. 476-485 ◽  
Author(s):  
Gang Liu ◽  
Xiaoqing Tan ◽  
Chao Dang ◽  
Shuangquan Tan ◽  
Shihui Xing ◽  
...  
Keyword(s):  
Left Hemisphere ◽  
Verbal Memory ◽  
Memory Impairment ◽  
Right Hemisphere ◽  
Brain Structures ◽  
Change Rate ◽  
Immediate Recall ◽  
Stroke Group ◽  
Left Hemisphere Stroke ◽  
Subcortical Infarction

Background. Subcortical infarcts can result in verbal memory impairment, but the potential underlying mechanisms remain unknown. Objective. We investigated the spatiotemporal deterioration patterns of brain structures in patients with subcortical infarction and identified the regions that contributed to verbal memory impairment. Methods. Cognitive assessment and structural magnetic resonance imaging were performed 1, 4, and 12 weeks after stroke onset in 28 left-hemisphere and 22 right-hemisphere stroke patients with subcortical infarction. Whole-brain volumetric analysis combined with a further-refined shape analysis was conducted to analyze longitudinal morphometric changes in brain structures and their relationship to verbal memory performance. Results. Between weeks 1 and 12, significant volume decreases in the ipsilesional basal ganglia, inferior white matter, and thalamus were found in the left-hemisphere stroke group. Among those 3 structures, only the change rate of the thalamus volume was significantly correlated with that in immediate recall. For the right-hemisphere stroke group, only the ipsilesional basal ganglia survived the week 1 to week 12 group comparison, but its change rate was not significantly correlated with the verbal memory change rate. Shape analysis of the thalamus revealed atrophies of the ipsilesional thalamic subregions connected to the prefrontal, temporal, and premotor cortices in the left-hemisphere stroke group and positive correlations between the rates of those atrophies and the change rate in immediate recall. Conclusions. Secondary damage to the thalamus, especially to the left subregions connected to specific cortices, may be associated with early verbal memory impairment following an acute subcortical infarct.

scholarly journals Reduced competition between tool action neighbors in left hemisphere stroke

Cortex ◽  
2019 ◽  
Vol 120 ◽  
pp. 269-283 ◽  
Author(s):  
Frank E. Garcea ◽  
Harrison Stoll ◽  
Laurel J. Buxbaum
Keyword(s):  
Left Hemisphere ◽  
Left Hemisphere Stroke
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