Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia

Innovative memory paradigms have been introduced to capture subtle memory changes in early Alzheimer’s disease (AD). We aimed to examine the associations between different indexes of the challenging Memory Binding Test (MBT) and hippocampal volume (HV) in a sample of individuals with subjective cognitive decline (SCD; n = 50), amnestic mild cognitive impairment (aMCI) due to AD ( n = 31), and cognitively normal (CN) older adults ( n = 29) recruited from the Czech Brain Aging Study, in contrast to traditional verbal memory tests. Both MBT free and cued recall scores in immediate and delayed recall conditions were associated with lower HV in both SCD and aMCI due to AD, whereas in traditional verbal memory tests only delayed recall scores were associated with lower HV. In SCD, the associations with lower HV in the immediate recall covered specific cued recall indexes only. In conclusion, the MBT is a promising test for detecting subtle hippocampal-associated memory decline during the predementia continuum.

Modality Effects in Free Recall: A Retrieved-Context Account

The modality effect refers to the robust finding that memory performance differs for items presented aurally, as compared with visually. Whereas auditory presentation leads to stronger recency performance in immediate recall, visual presentation often produces better primacy performance (the inverse modality effect). To investigate and model these differences, we conducted two large-scale web-based immediate free recall experiments. In both experiments, participants studied visual and auditory word lists of varying lengths and rates of presentation. We observed typical modality and inverse modality effects, while also discovering that participants were more likely to initiate recall from recent items on auditory trials than on visual trials. However, modality effects persisted regardless of the first item recalled. Meanwhile, an analysis of intrusion errors revealed that participants were more likely on visual trials than on auditory trials to erroneously recall words from one list prior. Furthermore, words presented in the same modality as the present list intruded more often than those presented in a different modality. We next developed a retrieved-context account of the modality effect by fitting the Context Maintenance and Retrieval model to data across multiple list lengths. Through our simulations, we demonstrate that the modality effect can be explained by faster contextual drift and stronger context-to-item association formation during auditory presentation, relative to visual. Our modeling shows that modality effects can arise without hypothesizing distinct memory stores for recent and remote information. Finally, we propose that modality effects may derive primarily from the temporal dynamics of stimuli, rather than their modality.

Effectiveness of immediate vs. delayed recall in detecting invalid performance in coached and uncoached simulators: Results of two experimental studies

Objective: Two experimental studies were conducted to compare the ability of immediate and delayed recall indicators to discriminate between performances of simulators and full-effort clinical and nonclinical participants. Methods: Three groups of simulators (uncoached, symptom-coached, and testcoached), one group of community controls, and one group of cognitively impaired patients were assessed with four experimental memory tests, in which the immediate and delayed recall tasks were separated by three other tasks. Results: Across both studies, delayed recall demonstrated higher accuracy than immediate recall in classifying simulated performances as invalid, as compared to performances of bona fide clinical participants. ROC curve results showed sensitivities below 50% for both indicators at specificities of ≥ 90%. Computing performance curves across recall trials revealed descending trends for all three simulator groups indicating a suppressed learning effect as a marker of noncredible performances. Among types of coaching, test-coaching proved to decrease differences between simulators and patients. Discussion: The effectiveness of such indicators in clinical evaluations and their vulnerability to information about test-taking strategies are discussed.

Concussion Assessment Across Several Clinical Batteries: Identifying the Components That Best Discriminate Injured Adolescents From Controls

ObjectiveTo identify which sub-components of 4 clinical assessments optimize concussion diagnosis.BackgroundMultiple assessments are part of the clinical toolbox for diagnosing concussions in youth, including the Post-Concussion Symptom Inventory (PCSI), the visio-vestibular exam (VVE), the King-Devick (KD) assessment, and the Sport Concussion Assessment Tool (SCAT-5). Most of these assessments have sub-components that likely overlap in aspects of brain function they assess. Discerning the combination of sub-components that best discriminate concussed adolescents (cases) from uninjured controls would streamline concussion assessment.Design/MethodsParticipants, 12–18 years, were prospectively enrolled from August 1, 2017 to April 29, 2020 Controls (n = 189, 53% female) were recruited from a suburban high school with PCSI, VVE, KD and SCAT-5 assessments associated with their sport seasons. Cases (n = 213, 52% female) were recruited from a specialty care concussion program, with the same assessments performed ≤28 days from injury. We implemented a forward-selection sparse principal component (PC) regression procedure to group sub-components into interpretable PCs and identify the PCs best able to discriminate cases from controls while accounting for age, sex, and concussion history.ResultsThe AUC of the baseline model with age, sex, and concussion history was 62%. The PC that combined all 5 sub-components of PCSI and SCAT-5 symptom count and symptom severity provided the largest AUC increase (+10.6%) relative to baseline. Other PC factors representing (1) KD completion time, (2) Errors in BESS tandem and double-leg stances, and (C) horizontal/vertical saccades and vestibular-ocular reflex also improved model AUC relative to baseline by 5.6%, 4.7%, and 4.5%, respectively. In contrast, the SCAT5 immediate recall test and right/left monocular accommodation did little to uniquely contribute to discrimination (<1% gain in AUC). Overall, the best model included 5 PCs (AUC = 77%).ConclusionsThese data show overlapping features of clinical batteries, with symptoms providing the strongest discrimination, but unique features obtained from neurocognitive, vision, and vestibular testing.

Learning Monologues at Bedtime Improves Sleep Quality in Actors and Non-Actors

Several studies show that pre-sleep learning determines changes in subsequent sleep, including improvements of sleep quality. Our aims were to confirm this finding using a more ecological task (learning a theatrical monologue) and to investigate whether the effect is modulated by expertise. Using a mixed design, we compared polysomnographic recordings of baseline sleep (BL, 9-h TIB) to those of post-training sleep (TR, with the same TIB but preceded by the training session), in one group of actors (N = 11) and one of non-actors (N = 11). In both groups, TR appears reorganized and re-compacted by the learning session, as shown, among others, by a significant decrease of WASO%, awakenings, arousals, and state transitions and by a trend towards an increased number of complete cycles and total cycle time. Concerning memory performance, the number of synonyms produced was significantly higher in the morning relative to immediate recall. No between-groups differences emerged either for sleep or memory variables. Our data confirm pre-sleep learning’s beneficial effect on sleep quality in an ecological context. While expertise appears not to influence memory-related sleep mechanisms, results on morning recall support the recent view that sleep’s role in memory processes consists in trace “transformation” for adaptive purposes, rather than rote consolidation.

Immediate recall as a secondary text: Referential parameters, pragmatics and propositions

Since the process of recalling combines comprehension and speech production, it is viewed as an extremely complex though understudied linguo-cognitive phenomenon. Recalls as secondary texts or text derivatives are also considered to be a good material to explore cognitive aspects of secondary texts production, information conversion procedures and types of transformations of primary texts. The notion of secondary texts also implies multiplicity, as an original text may be retranslated into numerous secondary texts different in quality and degree of completeness. The purpose of the study is to model the propositional secondary retold texts and to identify the specifics of the recipients interpretation of the main event in the text. It is aimed at discriminating the differences between the primary expository text and its 134 immediate recalls produced by 15-year old native Russian speakers. In order to reveal the specifics of the propositional content of a primary expository text and its recalls, their recipients used the following methodological operations: the description and interpretation of the semantic roles of the first and second arguments aligned to predicates on the basis of the verbs semantic properties; the employment of the psycholinguistic model of the utterances generation; the characteristic of memory as a complex of cognitive and mnemic processes; the definition of cognitive-semantic discourse structures; and the understanding of a proposition as a stable component of an utterance independent of the surface grammar. The comparison of the original text and its recalls with the use of innovative denotative maps enabled us to define successful and unsuccessful expression of propositional structures and the main idea of the original text. The classification of texts includes four groups based on the number of the reproduced propositions and types (weak or successful) of the reflection of the primary text denotative card. The authors designed and successfully implemented an innovative 11 stage-algorithm of revealing patterns of a printed text comprehension and its immediate recalls including the primary visual perception of the text, its primary interpretation, reading, encoding, reflection, preparation for an oral presentation, desobjectivation (distribution of semantic roles), interpretation, reflection, oral implementation and text. The work fills in certain gaps in the research, such as the specifics of immediate recalls production, identification of changes in propositional structures of immediate recalls, and expanding the corpus of semantic roles similar to Frame Net. The findings can be successfully applied in natural language processing and linguistic didactics.

Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele

The amygdala is known to be related to cognitive function. In this study, we used an automated approach to segment the amygdala into nine nuclei and evaluated amygdala and nuclei volumetric changes across the adult lifespan in subjects carrying the apolipoprotein E (ApoE) ε3/ε3 allele, and we related those changes to memory function alteration. We found that except the left medial nucleus (Me), whose volume decreased in the old group compared with the middle-early group, all other nuclei volumes presented a significant decline in the old group compared with the young group. Left accessory basal nucleus (AB) and left cortico-amygdaloid transition area (CAT) volumes were also diminished in the middle-late group. In addition, immediate memory recall is impaired by the process of aging, whereas delayed recall and delayed recognition memory functions were not significantly changed. We found significant positive correlations between immediate recall scores and volumes of the bilateral basal nucleus (Ba), AB, anterior amygdaloid area (AAA), CAT, whole amygdala, left lateral nucleus (La), left paralaminar nucleus (PL), and right cortical nucleus (Co). The results suggest that immediate recall memory decline might be associated with volumetric reduction of the amygdala and its nuclei, and the left AB and left CAT might be considered as potential imaging biomarkers of memory decline in aging.

Regression-Based Normative Data for Independent and Cognitively Active Spanish Older Adults: Free and Cued Selective Reminding Test, Rey–Osterrieth Complex Figure Test and Judgement of Line Orientation

The aim of this work was to develop normative data for neuropsychological tests for the assessment of independent and cognitively active Spanish older adults over 55 years of age. Methods: regression-based normative data were calculated from a sample of 103 nondepressed independent community-dwelling adults aged 55 or older (66% women). The raw data for the Free and Cued Selective Reminding Test (FCSRT), the Rey–Osterrieth Complex Figure Test (ROCF) and the Judgement of Line Orientation Test (JLO) were regressed on age, sex and education. The model predicting the FCSRT delayed-recall (FCSRT-Del) scores also included the FCSRT immediate-recall (FCSRT-Imm) scores. The model predicting the ROCF immediate-recall (ROCF-Imm) scores included the ROCF copy-trial (ROCF-C) scores, and the model predicting the ROCF delayed-recall (ROCF-Del) scores included both the ROCF-C and the ROCF-Imm scores. In order to identify low scores, z-scores were used to determine the discrepancy between the observed and the predicted scores. The base rates of the low scores for both the SABIEX normative data and the published normative data obtained from the general population were compared. Results: the effects of the different sociodemographic variables (age, sex and education) varied throughout the neuropsychological measures. Despite finding similar proportions of low scores between the normative data sets, the agreement was irrelevant or only fair-to-good. Conclusions: the normative data obtained from the general population might not be sensitive enough to identify low scores in cognitively active older adults, incorrectly classifying them as cognitively normal compared to the less active population.

Sensory Impairment and Algorithmic Classification of Early Cognitive Impairment in Middle-Aged and Older Adults

Sensory function has been linked to cognitive impairment and dementia, but the link between multiple sensory impairments and early cognitive impairment (ECI) is unclear. Sensory function (vision, hearing, vestibular, proprioception, and olfaction) was measured in 390 BLSA participants (age=75±8 years; 57% women; 69% white) from 2012 to 2018 over a mean 3.6 years. ECI was defined based on 1 standard deviation below age-and race-specific means in Card Rotations or California Verbal Learning Test immediate recall. Cox proportional hazard models examined the risk of ECI for each sensory impairment and across categories of impairments. Vision impairment (vs. no vision impairment) was associated with a 70% greater risk of ECI (HR=1.70, p=0.05). Participants with 1 or ≥2 sensory impairments had triple the risk of ECI (HR=3.74 and 3.44, p=0.008 and 0.02, respectively) compared to those without impairment. Future studies are needed to examine whether treatment for sensory impairments can modify these risks.

Telephone-Based Word List Recall and Hearing Ability

Certain consonant sounds called fricatives (e.g, “s” and “f”) are difficult to hear over the telephone; phones exclude high-frequency sounds that affect their intelligibility. This may be problematic for older adults responding to phone-based memory tests. Many older adults have some degree of hearing loss, and older men have it more in the high-frequency range. Hearing loss, in combination with phone bandwidth restrictions, may reduce older adults’ recall of fricative words. Participants (n=3,612, mean age=64.2, 60% women) in the 1998 wave of the Health and Retirement study (HRS) completed a word list immediate recall task over the phone. List 4 recall was examined because it was evenly split (5 each) between words with and without fricative consonant sounds. Subjective ratings of hearing and health, age, depression, and education were also measured. A Wilcoxon signed-rank test showed participants recalled fewer fricative (M=2.8) than nonfricative (M=3.0) words, Z=-8.47, p&lt;.001. An ordinal regression for fricative word recall indicated a sex by hearing interaction; males with worse hearing were less likely to recall more fricative words, OR=.94, 95% CI [.88, 1.01], p=.076, after controlling for age, education, health, and depression. An ordinal regression for nonfricative word recall did not show a main effect for hearing or a hearing by sex interaction. For both models, age, education, and health were related to recall. Consonant sounds may influence phone-based word recall, particularly for older men. Attention should be paid to word selection when designing phone-based cognitive tests in order to avoid memory impairment overestimation.