scholarly journals Safety and Usefulness of Cryobiopsy and Stamp Cytology for the Diagnosis of Peripheral Pulmonary Lesions

Cancers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 410 ◽  
Author(s):  
Tatsuya Imabayashi ◽  
Junji Uchino ◽  
Akihiro Yoshimura ◽  
Yusuke Chihara ◽  
Nobuyo Tamiya ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Diagnostic Yield ◽  
Diagnostic Technique ◽  
Histological Diagnosis ◽  
Tissue Samples ◽  
Pulmonary Lesions ◽  
Lung Cancer Diagnosis ◽  
Thoracic Drainage ◽  
Endobronchial Ultrasonography ◽  
Peripheral Pulmonary Lesions

Reports on the use of cryobiopsy (CB) for lung cancer diagnosis are limited. The aims of the present study were to evaluate the safety and usefulness of CB using radial endobronchial ultrasonography, without a guide sheath, for the diagnosis of peripheral pulmonary lesions and determine the utility of stamp cytology, an on-site diagnostic technique for determining tumor inclusion in CB samples. We retrospectively analyzed data for 35 patients (36 lesions) with suspected peripheral lung cancer who underwent CB between August 2017 and February 2019 at our medical facility. The diagnostic yield, incidence of complications, and the utility of stamp cytology for diagnosis were investigated. The diagnostic yield of CB was 86.1% (31/36) with histological diagnosis, and 80.5% (29/36) with diagnosis using stamp cytology; the overall yield was 91.6% (33/36). Pneumothorax requiring thoracic drainage occurred in two patients, both of whom had lesions contacting the pleura. Grade 2 and grade 1 bleeding occurred in one and 25 patients, respectively. CB enables the collection of very large, nearly intact tissue samples, thus resulting in an improvement in the true diagnosis rate and facilitating the measurement of multiple biomarkers as well as rapid histological diagnosis.

scholarly journals A Pilot Study of Transbronchial Biopsy Using Endobronchial Ultrasonography with a Guide Sheath in the Diagnosis of Peripheral Pulmonary Lesions in Patients with Interstitial Lung Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2269
Author(s):  
Takayasu Ito ◽  
Tomoki Kimura ◽  
Kensuke Kataoka ◽  
Shotaro Okachi ◽  
Keiko Wakahara ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Diagnostic Yield ◽  
Transbronchial Biopsy ◽  
Consecutive Series ◽  
Complication Rates ◽  
Pulmonary Lesions ◽  
Endobronchial Ultrasonography ◽  
Peripheral Pulmonary Lesions

The occurrence of interstitial lung disease (ILD) with peripheral pulmonary lesions (PPLs) is closely linked to the development of lung cancer. Yet, the best diagnostic approach for identifying PPLs in patients with ILD remains elusive. This study retrospectively investigated the application of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS) to the effective and safe diagnosis of PPLs when compared with conventional TBB. The study sample included a consecutive series of 19 patients with ILD who underwent conventional TBB or TBB using EBUS-GS at Tosei General Hospital between 1 April 2013 and 31 October 2015. The two techniques were compared based on diagnostic yield and associated complications. The diagnostic yield of EBUS-GS TBB was significantly higher than that of conventional TBB (p = 0.009), especially for small lesions (≤20 mm), lesions located in the lower lobes, lesions with a positive bronchus sign, and lesions visible by chest radiography (p = 0.010, p = 0.022, p = 0.006, and p = 0.002, respectively). There were no significant differences in complication rates. Therefore, EBUS-GS is an effective alternative for the diagnosis of PPLs in patients with ILD, without additional complications.

scholarly journals The utility of transbronchial rebiopsy for peripheral pulmonary lesions in patients with advanced non-squamous non-small cell lung cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Akiko Tateishi ◽  
Yuji Matsumoto ◽  
Midori Tanaka ◽  
Toshiyuki Nakai ◽  
Shinji Sasada ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Diagnostic Yield ◽  
Small Cell ◽  
Endobronchial Ultrasound ◽  
Small Cell Lung ◽  
Molecular Analyses ◽  
Pulmonary Lesions ◽  
Initial Biopsy ◽  
Peripheral Pulmonary Lesions

Abstract Background Patients treated for non-squamous (non-Sq) non-small cell lung cancer (NSCLC) often require repeat biopsies to determine the optimal subsequent treatment. However, the differences between rebiopsy and initial biopsy in terms of their diagnostic yields and their ability to test the molecular profiles using bronchoscopy with radial endobronchial ultrasound guidance in patients with advanced NSCLC remain unclear. Hence, we aimed to compare the diagnostic yields and ability for molecular analyses of rebiopsies with those of initial biopsies. Methods We investigated 301 patients with advanced non-Sq NSCLC who underwent radial endobronchial ultrasound-guided transbronchial biopsy (TBB) for peripheral pulmonary lesions (PPLs) between August 2014 and July 2017. Patients were divided into the rebiopsy and initial biopsy groups: the latter referred to the biopsy that determined the definitive diagnosis. The diagnostic yields and ability for molecular analyses were compared between the two groups, and the factors affecting the TBB diagnostic yield were identified using univariate and multivariate analyses. Results The diagnostic yields of the rebiopsy and initial biopsy groups were comparable (86.8 and 90.8%, respectively; p = 0.287). Furthermore, 93.0 and 94.0% of the patients in the rebiopsy and initial biopsy groups, respectively, had adequate specimens for gene profiling and mutational analysis (p = 0.765). The factors that increased the diagnostic yield were a positive bronchus sign (p < 0.001) and tumour location within the internal two-thirds of the lungs (p = 0.026). Conclusions The PPL diagnostic yield of the rebiopsy group was as high as that of the initial biopsy group. Hence, TBB for PPLs is feasible for patients requiring rebiopsy as well as for those with initial diagnoses. Adequate, high-quality biopsy specimens can be obtained by transbronchial rebiopsy for molecular testing.

Diagnostic yield of combined bronchoscopy and endobronchial ultrasonography, under LungPoint guidance for small peripheral pulmonary lesions

Respirology ◽  
2013 ◽  
Vol 18 (5) ◽  
pp. 834-839 ◽  
Author(s):  
Motohiro Tamiya ◽  
Norio Okamoto ◽  
Shinji Sasada ◽  
Takayuki Shiroyama ◽  
Naoko Morishita ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Pulmonary Lesions ◽  
Endobronchial Ultrasonography ◽  
Peripheral Pulmonary Lesions

scholarly journals Transbronchial Biopsy Using Endobronchial Ultrasonography with a Guide Sheath Increased the Diagnostic Yield of Peripheral Pulmonary Lesions

2012 ◽  
Vol 51 (5) ◽  
pp. 455-460 ◽  
Author(s):  
Masayuki Ishida ◽  
Motoi Suzuki ◽  
Akitsugu Furumoto ◽  
Yoshiko Tsuchihashi ◽  
Koya Ariyoshi ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Transbronchial Biopsy ◽  
Pulmonary Lesions ◽  
Endobronchial Ultrasonography ◽  
Peripheral Pulmonary Lesions

scholarly journals Endobronchial Ultrasonography with a Guide Sheath Transbronchial Biopsy for Diagnosing Peripheral Pulmonary Lesions within or near Fibrotic Lesions in Patients with Interstitial Lung Disease

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5751
Author(s):  
Takayasu Ito ◽  
Shotaro Okachi ◽  
Tomoki Kimura ◽  
Kensuke Kataoka ◽  
Yasuhiko Suzuki ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Diagnostic Yield ◽  
Transbronchial Biopsy ◽  
Probe Position ◽  
Factors Affecting ◽  
Pulmonary Lesions ◽  
Endobronchial Ultrasonography ◽  
Peripheral Pulmonary Lesions ◽  
Fibrotic Lesion

In patients with interstitial lung disease (ILD), the most frequent locations of lung cancer are within or near fibrotic lesions. However, the diagnostic yield for peripheral pulmonary lesions (PPLs) within or near fibrotic lesions using endobronchial ultrasonography with a guide sheath transbronchial biopsy (EBUS-GS TBB) may be unsatisfactory compared to that for PPLs distant from fibrotic lesions because of the difficulty in reaching the lesions. Our objectives were to evaluate the yield for PPLs using EBUS-GS TBB according to the proximity of PPLs to fibrotic lesions and to determine factors affecting the yield for PPLs. We retrospectively investigated 323 consecutive lesions using EBUS-GS TBB between 1 November 2014 and 31 December 2016. We identified PPLs with ILD in such lesions. PPLs with ILD were divided into PPLs within or near fibrotic lesions which met the criterion of PPLs, and of fibrotic lesions overlapping each other (PPLs-FL) and those distant from fibrotic lesions, which met the criterion of PPLs and the area of fibrotic lesion not overlapping each other (PPLs-NFL). Of the 323 lesions, 55 were included (31 PPLs-FL and 24 PPLs-NFL). The diagnostic yield for PPLs-FL was significantly lower than for PPLs-NFL (45.2% vs. 83.3%, p = 0.004). Multivariate analysis revealed that PPLs-NFL (odds ratio (OR) = 7.509) and a probe position within the lesion (OR = 4.172) were significant factors affecting diagnostic yield. Lesion’s positional relation to fibrotic lesions and the probe position were important factors affecting the successful diagnosis via EBUS-GS TBB in these patients.

Factors Related to Diagnostic Yield of Transbronchial Biopsy Using Endobronchial Ultrasonography With a Guide Sheath in Small Peripheral Pulmonary Lesions

CHEST Journal ◽  
2007 ◽  
Vol 132 (2) ◽  
pp. 603-608 ◽  
Author(s):  
Noriyuki Yamada ◽  
Koichi Yamazaki ◽  
Noriaki Kurimoto ◽  
Hajime Asahina ◽  
Eiki Kikuchi ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Transbronchial Biopsy ◽  
Pulmonary Lesions ◽  
Endobronchial Ultrasonography ◽  
Peripheral Pulmonary Lesions

scholarly journals Radial EBUS combined with a GS and VBN for diagnosis of peripheral lung lesions: a retrospective study

2020 ◽  
Author(s):  
Jian Zhang ◽  
Shuo-Yao Qu ◽  
Yan Zhang ◽  
Yong Zhang ◽  
Ming-Ming Wang ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Operation Time ◽  
Pulmonary Lesions ◽  
Small Probe ◽  
Gene Testing ◽  
Endobronchial Ultrasonography ◽  
Significant Difference ◽  
Total Examination Time ◽  
Peripheral Pulmonary Lesions ◽  
The Cost

Abstract Background More and more peripheral pulmonary lesions (PPL) have been found following the increased utilization of chest CT in China. But how to identify the nature of PPL accurately, safely and economically is the concern of Chinese doctors. The combination of radial endobronchial ultrasonography with a guide sheath and virtual bronchoscopic navigation was a deluxe scheme to indicate the pathology of peripheral pulmonary lesions in nation’s current medical level. This study aimed to compare the diagnostic yield, safety and health economics of EBUS-GS-VBN versus radial ultrasonic small probe plus thin bronchoscopy (EBUS) for diagnosis of PPLs. Methods This study was a single-institution retrospective review of PLLs examined by using EBUS-GS-VBN or radial EBUS between March 2018 and September 2018 consecutive. The diagnostic yields, accuracy, operation time, complications, factors influencing the diagnostic outcome, tissue genetic test rate and medical cost were analyzed separately. Results there was no significant difference in the diagnostic yield between the two groups (92.31% vs 88.57%, p = 0.594). Although the searching time of EBUS-GS-VBN was shorter (1.47 ± 0.49 min vs 2.12 ± 1.36 min, p < 0.001), procedure time was extended (24.07 ± 5.53 min vs 17.41 ± 4.38 min, p < 0.001). The diagnosis yield of malignancy and benign disease were equal (84.62% vs 100% and 95.35% vs 84%). There was no difference in the rate of gene testing between the two groups (75% vs 70.58%), while the incidence of Intrapulmonary hemorrhage in the EBUS-GS-VBN group was significantly descended. Moreover, the average expense of EBUS-GS-VBN was higher than that of EBUS-GS (6315 ± 1817 RMB vs 3128 ± 1086RMB). Conclusion When performing TBLB of PLLs, we found EBUS-GS-VBN to be similar to EBUS in accuracy. Although the founding lesion time of EBUS-GS-VBN group were significantly shorter, the total examination time was longer. Furthermore, the complications of EBUS-GS-VBN group were fewer. There was no difference in genetic testing between the two groups. It is worth noting that the cost and radiation exposure was lower of EBUS group patients. Trial registration: retrospectively registered

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