scholarly journals The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2837
Author(s):  
Edwin S Kulubya ◽  
Kaitlin Clark ◽  
Dake Hao ◽  
Sabrina Lazar ◽  
Arash Ghaffari-Rafi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Spina Bifida ◽  
Stromal Cells ◽  
Stromal Cell ◽  
Antioxidant Properties ◽  
Adult Tissue ◽  
Common Cause ◽  
Cord Injury ◽  
Fetal Repair

Spinal cord injury (SCI) is a devasting condition with no reliable treatment. Spina bifida is the most common cause of congenital SCI. Cell-based therapies using mesenchymal stem/stromal cells (MSCS) have been largely utilized in SCI. Several clinical trials for acquired SCI use adult tissue-derived MSC sources, including bone-marrow, adipose, and umbilical cord tissues. The first stem/stromal cell clinical trial for spina bifida is currently underway (NCT04652908). The trial uses early gestational placental-derived mesenchymal stem/stromal cells (PMSCs) during the fetal repair of myelomeningocele. PMSCs have been shown to exhibit unique neuroprotective, angiogenic, and antioxidant properties, all which are promising applications for SCI. This review will summarize the unique properties and current applications of PMSCs and discuss their therapeutic role for acquired SCI.

Safety of Autologous Bone Marrow Stromal Cell Transplantation in Dogs with Acute Spinal Cord Injury

2012 ◽  
Vol 41 (4) ◽  
pp. 437-442 ◽  
Author(s):  
Hidetaka Nishida ◽  
Masanari Nakayama ◽  
Hiroshi Tanaka ◽  
Masahiko Kitamura ◽  
Shingo Hatoya ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Autologous Bone Marrow ◽  
Marrow Stromal Cell ◽  
Cord Injury ◽  
Autologous Bone

Autologous Adipose Tissue-derived Stromal Cells for Treatment of Spinal Cord Injury

2006 ◽  
Vol 15 (4) ◽  
pp. 583-594 ◽  
Author(s):  
Soo-Kyung Kang ◽  
Myung-Joo Shin ◽  
Jin Sup Jung ◽  
Yong Geun Kim ◽  
Cheul-Hong Kim
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adipose Tissue ◽  
Stromal Cells ◽  
Cord Injury

Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury

Cytotherapy ◽  
2013 ◽  
Vol 15 (4) ◽  
pp. 434-448 ◽  
Author(s):  
Zhilai Zhou ◽  
Yinhai Chen ◽  
Hui Zhang ◽  
Shaoxiong Min ◽  
Bo Yu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Adipose Tissue ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cord Injury

Effects of Intrathecal Injection of the Conditioned Medium from Bone Marrow Stromal Cells on Spinal Cord Injury in Rats

2018 ◽  
Vol 35 (3) ◽  
pp. 521-532 ◽  
Author(s):  
Kenji Kanekiyo ◽  
Tamami Wakabayashi ◽  
Norihiko Nakano ◽  
Yoshihiro Yamada ◽  
Masahiro Tamachi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Conditioned Medium ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Intrathecal Injection ◽  
Marrow Stromal Cells ◽  
Cord Injury

scholarly journals Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury

2017 ◽  
Vol 18 (3) ◽  
pp. 377 ◽  
Author(s):  
Seung Hoon Lee ◽  
Yongsun Kim ◽  
Daeun Rhew ◽  
Ahyoung Kim ◽  
Kwang Rae Jo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Heme Oxygenase ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Heme Oxygenase 1 ◽  
Cord Injury
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