scholarly journals Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3214
Author(s):  
Krisztián Pajer ◽  
Tamás Bellák ◽  
Antal Nógrádi
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Pluripotent Stem Cells ◽  
Spinal Cord Injuries ◽  
New Era ◽  
Experimental Application ◽  
Cord Injury ◽  
Induced Pluripotent ◽  
Spinal Cord Repair

Hundreds of thousands of people suffer spinal cord injuries each year. The experimental application of stem cells following spinal cord injury has opened a new era to promote neuroprotection and neuroregeneration of damaged tissue. Currently, there is great interest in the intravenous administration of the secretome produced by mesenchymal stem cells in acute or subacute spinal cord injuries. However, it is important to highlight that undifferentiated neural stem cells and induced pluripotent stem cells are able to adapt to the damaged environment and produce the so-called lesion-induced secretome. This review article focuses on current research related to the secretome and the lesion-induced secretome and their roles in modulating spinal cord injury symptoms and functional recovery, emphasizing different compositions of the lesion-induced secretome in various models of spinal cord injury.

scholarly journals Long-Distance Axonal Growth from Human Induced Pluripotent Stem Cells after Spinal Cord Injury

Neuron ◽  
2014 ◽  
Vol 83 (4) ◽  
pp. 789-796 ◽  
Author(s):  
Paul Lu ◽  
Grace Woodruff ◽  
Yaozhi Wang ◽  
Lori Graham ◽  
Matt Hunt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Axonal Growth ◽  
Long Distance ◽  
Cord Injury ◽  
Induced Pluripotent

scholarly journals Early Intervention for Spinal Cord Injury with Human Induced Pluripotent Stem Cells Oligodendrocyte Progenitors

PLoS ONE ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. e0116933 ◽  
Author(s):  
Angelo H. All ◽  
Payam Gharibani ◽  
Siddharth Gupta ◽  
Faith A. Bazley ◽  
Nikta Pashai ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Early Intervention ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Oligodendrocyte Progenitors ◽  
Cord Injury ◽  
Induced Pluripotent

scholarly journals Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironment

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tamás Bellák ◽  
Zoltán Fekécs ◽  
Dénes Török ◽  
Zsuzsanna Táncos ◽  
Csilla Nemes ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Pluripotent Stem Cells ◽  
Functional Improvement ◽  
Cord Injury ◽  
Contusion Injury ◽  
Spinal Cord Contusion ◽  
Induced Pluripotent

AbstractSpinal cord injury results in irreversible tissue damage followed by a very limited recovery of function. In this study we investigated whether transplantation of undifferentiated human induced pluripotent stem cells (hiPSCs) into the injured rat spinal cord is able to induce morphological and functional improvement. hiPSCs were grafted intraspinally or intravenously one week after a thoracic (T11) spinal cord contusion injury performed in Fischer 344 rats. Grafted animals showed significantly better functional recovery than the control rats which received only contusion injury. Morphologically, the contusion cavity was significantly smaller, and the amount of spared tissue was significantly greater in grafted animals than in controls. Retrograde tracing studies showed a statistically significant increase in the number of FB-labeled neurons in different segments of the spinal cord, the brainstem and the sensorimotor cortex. The extent of functional improvement was inversely related to the amount of chondroitin-sulphate around the cavity and the astrocytic and microglial reactions in the injured segment. The grafts produced GDNF, IL-10 and MIP1-alpha for at least one week. These data suggest that grafted undifferentiated hiPSCs are able to induce morphological and functional recovery after spinal cord contusion injury.

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