Angiogenesis Inhibitors as Anti-Cancer Therapy Following Renal Transplantation: A Case Report and Review of the Literature

Solid organ transplant recipients on long-term immunosuppressive medication are at increased risk of developing malignancy, and treatment of advanced cancers with angiogenesis inhibitors in this context has not been widely studied. We present a case of recurrent high-grade serous ovarian carcinoma treated with paclitaxel and bevacizumab in the context of prior renal transplantation where the patient responded well to treatment with controlled toxicities, discussing the potential for increased rates of adverse events and drug interactions in this select population.

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Predictors of Long-Term Health-Related Quality of Life in Adolescent Solid Organ Transplant Recipients

Journal of Pediatric Psychology ◽

10.1093/jpepsy/jsr007 ◽

2011 ◽

Vol 36 (8) ◽

pp. 891-901 ◽

Cited By ~ 32

Author(s):

Katie A. Devine ◽

Bonney Reed-Knight ◽

Kristin A. Loiselle ◽

Laura E. Simons ◽

Laura L. Mee ◽

...

Keyword(s):

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Health Related Quality ◽

Transplant Recipients ◽

Related Quality ◽

Health Related ◽

Solid Organ Transplant Recipients

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Viral Enteritis in Solid-Organ Transplantation

Viruses ◽

10.3390/v13102019 ◽

2021 ◽

Vol 13 (10) ◽

pp. 2019

Author(s):

Anum Abbas ◽

Andrea J. Zimmer ◽

Diana Florescu

Keyword(s):

Solid Organ Transplantation ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Post Transplantation ◽

Organ Transplant Recipients ◽

Increased Risk ◽

Viral Enteritis ◽

Solid Organ Transplant Recipients

Solid organ transplant recipients are at increased risk for infections due to chronic immunosuppression. Diarrhea is a commonly encountered problem post transplantation, with infectious causes of diarrhea being a frequent complication. Viral infections/enteritides in solid organ transplant recipients often result from frequently encountered pathogens in this population such as cytomegalovirus, adenovirus, and norovirus. However, several emerging viral pathogens are increasingly being recognized as more sensitive diagnostic techniques become available. Treatment is often limited to supportive care and reduction in immunosuppression, though antiviral therapies mayplay a role in the treatment in certain diseases. Viral enteritis is an important entity that contributes to morbidity and mortality in transplant recipients.

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Scedosporiosis in a Combined Kidney and Liver Transplant Recipient: A Case Report of Possible Transmission from a Near-Drowning Donor

Case Reports in Transplantation ◽

10.1155/2016/1879529 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Rachael Leek ◽

Erika Aldag ◽

Iram Nadeem ◽

Vikraman Gunabushanam ◽

Ajay Sahajpal ◽

...

Keyword(s):

Solid Organ Transplantation ◽

Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Near Drowning ◽

Saprobic Fungi ◽

Increased Risk ◽

Serious Infections ◽

Solid Organ Transplant Recipients ◽

Immunocompromised Hosts

Scedosporium spp. are saprobic fungi that cause serious infections in immunocompromised hosts and in near-drowning victims. Solid organ transplant recipients are at increased risk of scedosporiosis as they require aggressive immunosuppression to prevent allograft rejection. We present a case of disseminated Scedosporium apiospermum infection occurring in the recipient of a combined kidney and liver transplantation whose organs were donated by a near-drowning victim and review the literature of scedosporiosis in solid organ transplantation.

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LONG-TERM RESULTS IN SOLID ORGAN TRANSPLANT RECIPIENTS CONVERTED FROM CALCINEURIN-INHIBITORS TO SIROLIMUS

Transplantation Journal ◽

10.1097/00007890-200407271-00307 ◽

2004 ◽

Vol 78 ◽

pp. 115-116

Author(s):

M F. Egidi ◽

A Lo ◽

M Mya ◽

L W Gaber ◽

K Lau ◽

...

Keyword(s):

Organ Transplant ◽

Calcineurin Inhibitors ◽

Solid Organ Transplant ◽

Long Term Results ◽

Solid Organ ◽

Transplant Recipients ◽

Organ Transplant Recipients ◽

Solid Organ Transplant Recipients

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The Role of Systems Vaccinology in Understanding the Immune Defects to Vaccination in Solid Organ Transplant Recipients

Frontiers in Immunology ◽

10.3389/fimmu.2020.582201 ◽

2020 ◽

Vol 11 ◽

Author(s):

Nicholas Scanlon ◽

Youssef Saklawi ◽

Nadine Rouphael

Keyword(s):

Systems Biology ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Organ Transplant Recipients ◽

Organ Rejection ◽

Increased Risk ◽

Solid Organ Transplant Recipients ◽

Immune Defects

Solid organ transplant recipients (SOTRs) are at increased risk for many infections, whether viral, bacterial, or fungal, due to immunosuppressive therapy to prevent organ rejection. The same immune defects that render transplanted patients susceptible to infection dampen their immune response to vaccination. Therefore, it is vital to identify immune defects to vaccination in transplant recipients and methods to obviate them. These methods can include alternative vaccine composition, dosage, adjuvants, route of administration, timing, and re-vaccination strategies. Systems biology is a relatively new field of study, which utilizes high throughput means to better understand biological systems and predict outcomes. Systems biology approaches have been used to help obtain a global picture of immune responses to infections and vaccination (i.e. systems vaccinology), but little work has been done to use systems biology to improve vaccine efficacy in immunocompromised patients, particularly SOTRs, thus far. Systems vaccinology approaches may hold key insights to vaccination in this vulnerable population.

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