scholarly journals Non-Invasive Diagnosis of Malignancies Based on the Analysis of Markers in Exhaled Air

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 934
Author(s):  
Vladimir I. Chernov ◽  
Evgeniy L. Choynzonov ◽  
Denis E. Kulbakin ◽  
Ekaterina N. Menkova ◽  
Elena V. Obkhodskaya ◽  
...  
Keyword(s):  
Neural Network ◽  
Lung Cancer ◽  
Early Diagnosis ◽  
Laryngeal Cancer ◽  
International Standards ◽  
Diagnostic Device ◽  
Non Invasive ◽  
Number Of Patients ◽  
Exhaled Air ◽  
Invasive Method

Novel non-invasive methods for the diagnosis of malignancies should be effective for early diagnosis, reproducible, inexpensive, and independent from the human factor. Our aim was to establish the applicability of the non-invasive method, based on the analysis of air exhaled by patients who are at different stages of oropharyngeal, larynx and lung cancer. The diagnostic device includes semiconductor sensors capable of measuring the concentrations of gas components in exhaled air, with the high sensitivity of 1 ppm. The neural network uses signals from these sensors to perform classification and identify cancer patients. Prior to the diagnostic procedure of the non-invasive method, we clarified the extent and stage of the tumor according to current international standards and recommendations for the diagnosis of malignancies. The statistical dataset for neural network training and method validation included samples from 121 patients with the most common tumor localizations (lungs, oropharyngeal region and larynx). The largest number of cases (21 patients) were lung cancer, while the number of patients with oropharyngeal or laryngeal cancer varied from 1 to 9, depending on tumor localization (oropharyngeal, tongue, oral cavity, larynx and mucosa of the lower jaw). In the case of lung cancer, the parameters of the diagnostic device are determined as follows: sensitivity—95.24%, specificity—76.19%. For oropharyngeal cancer and laryngeal cancer, these parameters were 67.74% and 87.1%, respectively. This non-invasive method could lead to relevant medicinal findings and provide an opportunity for clinical utility and patient benefit upon early diagnosis of malignancies.

The Central Slip Tenodesis Test for Early Diagnosis of Potential Boutonnière Deformities

1994 ◽  
Vol 19 (1) ◽  
pp. 88-90 ◽  
Author(s):  
P. J. SMITH ◽  
D. A. ROSS
Keyword(s):  
Early Diagnosis ◽  
Conservative Management ◽  
Primary Defect ◽  
Non Invasive ◽  
Boutonniere Deformity ◽  
Invasive Method ◽  
Central Slip ◽  
Boutonnière Deformity

Disruption of the central slip is the primary defect leading to boutonnière deformity. In the closed injury early diagnosis of this lesion is rarely achieved due to the limitations of current methods and difficulties encountered in assessing a painful finger. We describe a simple, non-invasive method of diagnosis which can be carried out on all patients and with minimal discomfort. This test is also beneficial in monitoring the progress of conservative management of central slip disruption.

scholarly journals Development of a Non-Invasive Method, Multiplex Methylation Specific PCR (MMSP), for Early Diagnosis of Nasopharyngeal Carcinoma

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e45908 ◽  
Author(s):  
Zhe Zhang ◽  
Di Sun ◽  
Susanna Hilda Hutajulu ◽  
Imran Nawaz ◽  
Do Nguyen Van ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Early Diagnosis ◽  
Non Invasive ◽  
Methylation Specific Pcr ◽  
Specific Pcr ◽  
Invasive Method

scholarly journals ACCURACY OF TRANSVAGINAL ULTRASONOGRAPHY COMPARED TO ENDOMETRIAL BIOPSY FOR THE ETIOLOGICAL DIAGNOSIS OF ABNORMAL PERIMENOPAUSAL BLEEDING

2017 ◽  
Vol 90 (1) ◽  
pp. 33-39
Author(s):  
Renata Nicula ◽  
Doru Diculescu ◽  
Codruţa Claudia Lencu ◽  
Răzvan Ciortea ◽  
Carmen Elena Bucuri ◽  
...  
Keyword(s):  
Transvaginal Ultrasound ◽  
Endometrial Adenocarcinoma ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Accurate Identification ◽  
Non Invasive ◽  
Number Of Patients ◽  
Invasive Method

Background and aims. Perimenopause is marked by clinical manifestations which disturb everyday life and which may also hide a pathomorphological, more precisely endometrial, substrate. An accurate early diagnosis established by accessible, non-invasive methods is very important for the therapeutic management.Method. The study included 103 patients aged between 41.5–55.11 years, divided into 3 age groups: 40-44 years (n=10), 45-49 years (n=54) and ≥50 years (n=39).Results. Certain risk factors of endometrial neoplasm or premalignant conditions were evidenced, their accurate identification being useful in limiting the number of patients with abnormal uterine bleeding (AUB) submitted to diagnostic screening. The most common cause of AUB in our study was fibroma, followed by functional causes.Conclusions. Transvaginal ultrasound (TVUS) represents a minimally invasive method for the screening of perimenopausal patients with AUB, especially to rule out endometrial adenocarcinoma (EAC). TVUS sensitivity was higher than clinical diagnosis in case of leiomioma, polypi and EAC. TVUS was more accurate in the diagnosis of EAC, polypi and leiomioma.

scholarly journals POSSIBILITIES OF EARLY DIAGNOSIS AND PROPHYLAXIS OF INTRAOPERATIVE BILE DUCT LESIONS IN MIRIZZY SYNDROME

2020 ◽  
pp. 49-52
Author(s):  
B. S. Zaporozhchenko ◽  
D. A. Bondarets ◽  
I. E. Borodaev ◽  
I. V. Sharapov ◽  
A. Yu. Sharapova
Keyword(s):  
Bile Duct ◽  
Early Diagnosis ◽  
Acute Calculous Cholecystitis ◽  
Number Of Patients ◽  
Invasive Method ◽  
Group A ◽  
Bile Duct Lesions ◽  
High Degree ◽  
Calculous Cholecystitis

Summary. Goal. To analyze the possibilities of early diagnosis and prevention of intraoperative injuries of the bile duct in the Mirizzy syndrome. Materials and research methods. The study is based on an analysis of 968 case histories of patients with acute calculous cholecystitis. The ratio of patients with Mirizzy syndrome to patients with calculous cholecystitis was 38 (3.9 %). There were 716 women (74 %), and 252 men (26 %). The age of patients ranged from 25 to 92 years. All patients with Mirizzy syndrome were divided into 4 groups (according to the classification of A. Csendes). The number of patients with type 1 SM was 27 (72 %); 2 types — 6 (18 %); 3 types — 2 (6 %); 4 types — 1 (3 %). Result. The treatment outcome of 35 patients with Mirizzy syndrome was evaluated. In type 1, LCE was performed in 27 (72 %) patients. In type 2, open surgery was performed. In 4 (12 %) patients of this group, a laparotomy was performed for cholecystectomy with plastic surgery of the common bile duct on Keru drainage. In 2 (6 %), subtotal cholecystectomy was performed with subsequent installation of drainage into the lumen of the remaining part of the bladder with fistula. In the presence of types 3 and 4 of Mirizzy’s syndrome, an “open” surgical intervention was performed, followed by hepaticojejunoanastomosis on the Loop-off loop in 3 (9 %) patients. The most informative non-invasive method of preoperative diagnosis of Mirrisi syndrome is MRI in cholangiography, which allows you to diagnose all types of this syndrome with a high degree of probability.

Discovery of a novel linc01125 isoform in serum exosomes as a promising biomarker for NSCLC diagnosis and survival assessment

2021 ◽  
Author(s):  
Jianfeng Xian ◽  
Yuyuan Zeng ◽  
Shizhen Chen ◽  
Liming Lu ◽  
Li Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Area Under The Curve ◽  
Lung Cancer Patients ◽  
Non Invasive ◽  
Invasive Method ◽  
Highly Correlated ◽  
Nsclc Patients ◽  
Serum Exosomes

Abstract A non-invasive method to distinguish potential lung cancer patients would improve lung cancer prevention. We employed the RNA-Seq analysis to profile serum exosomal long non-coding RNAs (lncRNAs) from non-small cell lung cancer (NSCLC) patients and pneumonia controls, and then determined the diagnostic and prognostic value of a promising lncRNA in four datasets. We identified 90 dysregulated lncRNAs for NSCLC and found the most significant lncRNA was a novel isoform of linc01125. Serum exosomal linc01125 could distinguish NSCLC cases from disease-free and tuberculosis controls, with the area under the curve (AUC) values as 0.662 (95% confidence interval [CI]= 0.614-0.711) and 0.624 (95%CI= 0.522–0.725), respectively. High expression of exosomal linc01125 was also correlated with an unfavorable overall survival of NSCLC (hazard ratio [HR] = 1.58, 95%CI = 1.01–2.49). Clinic treatment decreased serum exosomal linc01125 in NSCLC patients (P = 0.036). Linc01125 functions to inhibit cancer growth and metastasis via acting as a competing endogenous RNA to up-regulate TNFAIP3 expression by sponging miR-19b-3p. Notably, the oncogenic transformation of 16HBE leads to decreased linc01125 in cells but increased linc01125 in cell-derived exosomes. The expression of linc01125 in total exosomes was highly correlated with that in tumor-associated exosomes in serum. Moreover, lung cancer cells were capable of releasing linc01125 into exosomes in vitro and in vivo. Our analyses suggest serum exosomal linc01125 as a promising biomarker for non-invasively diagnosing NSCLC and predicting the prognosis of NSCLC.

scholarly journals Non-invasive method for early diagnosis of herpes simplex encephalitis.

1988 ◽  
Vol 63 (12) ◽  
pp. 1470-1473 ◽  
Author(s):  
N Hanada ◽  
S Kido ◽  
M Terashima ◽  
K Nishikawa ◽  
T Morishima
Keyword(s):  
Herpes Simplex ◽  
Early Diagnosis ◽  
Herpes Simplex Encephalitis ◽  
Non Invasive ◽  
Invasive Method

scholarly journals Syndrome "empty" Turkish saddle

1999 ◽  
Vol 45 (3) ◽  
pp. 42-47
Author(s):  
M. B. Babarina
Keyword(s):  
Magnetic Resonance Imaging ◽  
Pituitary Adenoma ◽  
Sellar Region ◽  
Combined Exposure ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Number Of Patients ◽  
Invasive Method ◽  
Magnetic Resonance Imaging Mri ◽  
Methods Of Treatment

The syndrome of the "empty" Turkish saddle (PTS) is one of the poorly studied problems of neuroendocrinology. The urgency of this problem has increased at the present time with the widespread use in the diagnosis of the non-invasive method of magnetic resonance imaging (MRI), as well as with the increase in the number of patients exposed to radiation, surgical, combined exposure due to pituitary adenoma. The term "PTS syndrome" should be understood as the prolapse of the suprasellar tank into the cavity of the Turkish saddle with the pituitary gland spreading along the bottom and walls of the Turkish saddle, accompanied by endocrine, neurological and visual impairment. There are primary (idiopathic) and secondary PTS, which occurs after radiation, surgical and combined methods of treatment of diseases of the chiasm-sellar region. This review will focus mainly on primary PTS syndrome.

scholarly journals A Non-Invasive Glucose Analysis Model with a Carbon Nanotube Sensor

2019 ◽  
Vol 25 (4) ◽  
pp. 189-192 ◽  
Author(s):  
Nicolescu Adrian Eracle ◽  
Rusali Lavinia ◽  
Vasile Monica
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Analysis Model ◽  
Permeable Membrane ◽  
Noninvasive Measurements ◽  
Non Invasive ◽  
Exhaled Air ◽  
Invasive Method ◽  
Air Sample ◽  
New Applications

Abstract The development and studies related to carbon nanotubes, due to their physical properties and small sizes, are revealing new applications in the medical field. The present paper is proposing a non-invasive method of patient glycemia measurement by mean of carbon nanotubes based sensor. Due to their small sizes and elastic properties, carbon nanotubes are able to oscillate under the weight of small molecules capable of fixing on their body structure. After piezoelectric activation, the carbon nanotubes sensor based, is able to detect the variation of oscillations produced in nanotubes due to acetone molecules diffused through a selectively permeable membrane from the exhaled air, and attached to the nanotubes. The mathematical model taken into accont shows a linear dependence between the concentration of acetone in blood and glycemia, and makes the carbon nanotube sensor suitable for indirect estimation of the glycemia by noninvasive measurements made on the exhaled air sample, providing zero risk for the patient and absence of stress during the measurements.

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