scholarly journals A Case Report of Tongue Lymphoepithelial Carcinoma with a Histological Diagnostic Dilemma

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1039
Author(s):  
Daisuke Takeda ◽  
Manabu Shigeoka ◽  
Tenyu Sugano ◽  
Nanae Yatagai ◽  
Takumi Hasegawa ◽  
...  
Keyword(s):  
Histological Finding ◽  
Atypical Epithelium ◽  
Diagnostic Dilemma ◽  
Barr Virus ◽  
Japanese Female ◽  
Old Japanese ◽  
Neoplastic Change ◽  
Diagnostic Difficulties ◽  
Epstein Barr ◽  
Characteristic Features

Most head and neck lymphoepithelial carcinomas (LECs) arise in the nasopharynx and harbor Epstein–Barr virus (EBV). LEC is also a rare subtype of the oral squamous cell carcinoma (SCC). Morphologically, LEC is defined as resembling non-keratinizing nasopharyngeal carcinoma, undifferentiated subtype. The histological features and pathogenesis of oral LEC are not established. We describe a case of tongue LEC with histopathological diagnostic difficulties. A 72-year-old Japanese female presented with a whitish change on her left-side tongue. The diagnosis was atypical epithelium; neoplastic change could not be ruled out by a biopsy. Although the lesion was monitored at our hospital per her request, invasive carcinoma was detected 11 months later. Microscopically, conventional SCC was observed with the characteristic features as LEC confined to the deep part of the lesion. We briefly discuss this unusual histological finding and make a novel proposal for distinguishing oral LEC from LECs in other regions based on these histological findings.

Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome

2004 ◽  
Vol 31 (3) ◽  
pp. 235-238 ◽  
Author(s):  
Satoshi Sato ◽  
Hisashi Kawashima ◽  
Hisashi Oshiro ◽  
Daisuke Hasegawa ◽  
Yasuyo Kashiwagi ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Hemophagocytic Syndrome ◽  
Fatal Outcome ◽  
Barr Virus ◽  
Japanese Female ◽  
Old Japanese ◽  
Epstein Barr

A fulminant case of classical Hodgkin lymphoma: A diagnostic dilemma of Epstein‐Barr virus‐positive large B‐cell neoplasms

2019 ◽  
Vol 69 (7) ◽  
pp. 407-413
Author(s):  
Shojiro Ichimata ◽  
Mikiko Kobayashi ◽  
Maki Ohya ◽  
Toshiaki Otsuki ◽  
Katsuya Yanagisawa ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Epstein Barr Virus ◽  
Classical Hodgkin Lymphoma ◽  
Diagnostic Dilemma ◽  
Barr Virus ◽  
Epstein Barr ◽  
Large B Cell

scholarly journals Intrahepatic Cholangiocarcinoma With Lymphoepithelioma-like Carcinoma Components Not Associated With Epstein-Barr Virus: Report of a Case

2015 ◽  
Vol 100 (4) ◽  
pp. 689-695 ◽  
Author(s):  
Suefumi Aosasa ◽  
Tadashi Maejima ◽  
Akifumi Kimura ◽  
Kiyoshi Nishiyama ◽  
Hiromi Edo ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Epstein Barr Virus ◽  
Lymphocytic Infiltration ◽  
Caudate Lobe ◽  
Cytokeratin 19 ◽  
Limited Information ◽  
Barr Virus ◽  
Epstein Barr ◽  
Characteristic Features ◽  
Immunohistochemical Studies

A carcinoma displaying undifferentiated features with dense lymphoplasmacytic infiltration is defined as lymphoepithelioma-like carcinoma (LELC). Intrahepatic cholangiocarcinoma (ICC) with LELC components is rare, and most LELCs are associated with Epstein-Barr virus (EBV). We report here on a case of ICC with LELC components not associated with EBV. A 65-year-old woman was incidentally found to have a hepatic tumor in the caudate lobe. An extended right hepatectomy with lymphadenectomy was performed. Histologically, the tumor was mainly composed of large undifferentiated epithelial cells with vesicular nuclei, prominent nucleoli, indistinct cell borders, and heavy small lymphocytic infiltration, which are the characteristic features of LELC. Immunohistochemical studies revealed that the tumor cells were positive for cytokeratin 19 but were negative for glypican 3. In situ hybridization using EBV-encoded RNA was negative. Therefore, a diagnosis of ICC with LELC components not associated with EBV was made. Because there is limited information available regarding the prognosis and treatment of ICC with LELC components because of the limited number of reported cases, additional studies will be needed to clarify the clinicopathologic features of this disease.

scholarly journals Primary Hepatic Lymphoma in a Patient with Rheumatoid Arthritis Treated with Methotrexate

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Goichi Tatsumi ◽  
Naoya Ukyo ◽  
Hirokazu Hirata ◽  
Mitsuru Tsudo
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cell Lymphoma ◽  
Japanese Woman ◽  
Rapid Progression ◽  
Low Grade ◽  
Primary Hepatic Lymphoma ◽  
Barr Virus ◽  
Elevated Liver Enzymes ◽  
Old Japanese ◽  
Epstein Barr

Primary hepatic lymphoma (PHL) has rarely been reported in patients with immunosuppression. We herein describe a case of Epstein-Barr virus- (EBV-) positive PHL in a 67-year-old Japanese woman receiving methotrexate (MTX) treatment for rheumatoid arthritis (RA). The patient, who had been receiving MTX therapy for more than 6 years, presented with low-grade fever and abdominal pain. Initial laboratory tests showed mildly elevated liver enzymes with normal levels of alpha-fetoprotein and carcinoembryonic antigen, and computed tomography scans revealed multiple hepatic tumors with no lymph-node swelling. Examination of liver specimens obtained via ultrasonography-guided needle biopsy indicated EBV-positive diffuse large B cell lymphoma; therefore, she was diagnosed with PHL. MTX was discontinued, and she was carefully monitored thereafter owing to the prolonged history of MTX administration for RA. Rapid progression of PHL was observed; therefore 10 days after the PHL diagnosis, she received 6 cycles of R-THP-COP (rituximab, cyclophosphamide, pirarubicin, vincristine, and prednisolone) therapy and achieved complete remission for more than 1 year. Although MTX-associated lymphoproliferative disorders often show remission after withdrawal of MTX, early diagnosis and treatment are essential for PHL in patients with RA treated with MTX, because of the aggressive nature of the disease.

scholarly journals Autoimmune hepatitis following Epstein-Barr virus infection: a diagnostic dilemma

2019 ◽  
Vol 12 (7) ◽  
pp. e229615 ◽  
Author(s):  
Haoran Peng ◽  
Tanna Lim ◽  
Jae Nam ◽  
Jin Lee
Keyword(s):  
Autoimmune Hepatitis ◽  
Epstein Barr Virus ◽  
Case Reports ◽  
Acute Infection ◽  
Epstein Barr Virus Infection ◽  
Diagnostic Dilemma ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Barr Virus Infection

Epstein-Barr virus (EBV) infections frequently affect the liver and cause hepatitis. EBV is a well-known trigger of certain autoimmune diseases. There are few case reports showing the evidence of autoimmune hepatitis (AIH) following EBV infection. However, the diagnosis of AIH is very challenging in the setting of an acute infection. Here, we demonstrate a case of AIH following EBV infection in a patient ultimately recovered after receiving treatment for AIH.

Plasmablastic lymphoma versus plasmablastic myeloma: an ongoing diagnostic dilemma

2017 ◽  
Vol 70 (9) ◽  
pp. 775-780 ◽  
Author(s):  
Janice S Ahn ◽  
Ryan Okal ◽  
Jeffrey A Vos ◽  
Matthew Smolkin ◽  
Abraham S Kanate ◽  
...  
Keyword(s):  
In Situ Hybridisation ◽  
Diagnostic Algorithm ◽  
Clinical History ◽  
Lessons Learned ◽  
Plasmablastic Lymphoma ◽  
Detailed Knowledge ◽  
Diagnostic Dilemma ◽  
Barr Virus ◽  
Genetic Features ◽  
Epstein Barr

AimsTo determine the utility of clinical, morphological and phenotypical features in the differential diagnosis of plasmablastic lymphoma and myeloma with plasmablastic features.MethodsAll plasmablastic neoplasms identified from a 15-year retrospective search were reviewed and classified into ‘lymphoma’, ‘myeloma’ or ‘indeterminate’. The classification was then compared with the previously established clinical diagnosis. Lessons learned from this review were used to design a diagnostic algorithm for pathologists to use in the absence of known clinical history.ResultsThe classification was possible in 10 of 11 cases, 8 lymphomas and 2 myelomas (n=2). No distinctive morphological or phenotypical features were identified. The most useful histopathological parameter was a positive Epstein-Barr virus in situ hybridisation. Presence of associated lymphadenopathy and/or oral mass in the absence of complete myeloma-defining signs was used to favour a diagnosis of lymphoma in 4 of 8 cases.ConclusionsThe distinction between plasmablastic lymphoma from plasmablastic myeloma warrants detailed knowledge of clinical, radiological and laboratorial findings. New studies identifying distinctive phenotypical or genetic features are needed to improve the histopathological differentiation of plasmablastic neoplasms.

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