scholarly journals Capabilities of Modern Semiconductor Gamma Cameras in Radionuclide Diagnosis of Coronary Artery Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2130
Author(s):  
Michał Błaszczyk ◽  
Zbigniew Adamczewski ◽  
Anna Płachcińska
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Imaging Modality ◽  
Myocardial Flow Reserve ◽  
Fractional Flow ◽  
Gamma Cameras ◽  
Flow Reserve ◽  
Perfusion Studies ◽  
Artery Disease ◽  
Myocardial Flow

This paper presents a review of the literature concerning the clinical application of modern semiconductor (CZT) gamma cameras in the radioinuclide diagnosis of coronary artery disease. It contains information on the diagnostic efficacy of myocardial perfusion studies performed with those cameras compared with the widely used scintillation (Anger) cameras, an overview of their effectiveness in comparison with coronary angiography (also fractional flow reserve) and currently available clinical results of a myocardial flow reserve measured with a dynamic SPECT study. Introduction of this imaging modality to the measurement of a myocardial flow reserve aims to facilitate access to this type of study compared to the less available and more expensive PET method used so far.

scholarly journals Risk Stratification in Coronary Artery Disease using NH3-PET Myocardial Flow Reserve and CAD-RADS on Coronary CT Angiography

2021 ◽  
Author(s):  
Atsushi Yamamoto ◽  
Michinobu Nagao ◽  
Kiyoe Ando ◽  
Risako Nakao ◽  
Kenji Fukushima ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Stratification ◽  
Heart Diseases ◽  
Myocardial Flow Reserve ◽  
Coronary Syndrome ◽  
Flow Reserve ◽  
Significant Difference ◽  
Artery Disease ◽  
Myocardial Flow

Abstract PurposeMyocardial flow reserve (MFR) derived from 13N-ammonia positron emission tomography (NH3-PET) can predict the prognosis of patients with various heart diseases. Coronary computed tomography angiography (CCTA) is a non-invasive investigation for ischemic heart disease. The coronary artery disease reporting and data system (CAD-RADS) was established to standardize and facilitate the reporting of CCTA data regarding CAD. This study aimed to investigate the prognostic value of CAD-RADS and MFR.MethodsA total of 133 patients who underwent NH3-PET and CCTA within 3 months were enrolled. Patients were divided into groups with CAD-RADS 0-2 and ≥3 and into groups with MFR ≥2.0 and <2.0. The endpoint was major adverse cardiac events (MACE) comprising all-cause death, acute coronary syndrome, hospitalization due to heart failure, and cerebrovascular disease. The ability of CAD-RADS and MFR to predict MACE was analyzed using Kaplan-Meier analysis.ResultsThere was no significant difference in MFR between patients with CAD-RADS 0-2 and ≥3 (2.3±0.9 vs. 2.2±0.7, p=0.50). The MACE rate for patients with CAD-RADS 0-2 and ≥3 was equivalent (log-rank test, p=0.64). Patients with MFR <2.0 had a significantly higher MACE rate than those with MFR ≥2.0 (p=0.017). In patients with CAD-RADS ≥3, patients with MFR <2.0 had a significantly higher MACE rate than those with MFR ≥2.0 (p=0.034).ConclusionCAD-RADS did not contribute to MACE prediction. Conversely, MFR was useful in predicting MACE, allowing for further risk stratification in addition to CAD-RADS.

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