scholarly journals Effectiveness of a New Exercise Program after Lower Limb Arterial Blood Flow Surgery in Patients with Peripheral Arterial Disease: A Randomized Clinical Trial

2014 ◽  
Vol 11 (8) ◽  
pp. 7961-7976 ◽  
Author(s):  
Edita Jakubsevičienė ◽  
Donatas Vasiliauskas ◽  
Linas Velička ◽  
Raimondas Kubilius ◽  
Eglė Milinavičienė ◽  
...  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Débora Pantuso Monteiro ◽  
Giane Amorim Ribeiro-Samora ◽  
Raquel Rodrigues Britto ◽  
Danielle Aparecida Gomes Pereira

Abstract The primary objective of this study was to compare the effects on muscle metabolism of two types of aerobic training, with and without a load on the lower limbs, in adults with peripheral arterial disease (PAD). A simple blind randomized clinical trial was conducted using two groups: conventional aerobic (CG) and modified aerobic with a load on the lower limbs (MG). Both groups underwent training by walking three times a week over a 12-week period. The ratings of muscle metabolism were determined after a treadmill test with constant velocity and inclination concomitant with the use of near infrared spectroscopy (NIRS). Altogether 40 individuals with PAD (CG = 65.45 ± 10.60 and MG = 63.10 ± 10.54) were included in the study. After the intervention, in both groups, there was a reduction in the relative time to recovery (p = 0.002), an improvement in the re-oxygenation rate (p = 0.017), an increased time of resistance after reaching the lowest muscle oxygen saturation (StO2) (p < 0.001), an increase in the distance walked (p < 0.001), and an improvement of the walking economy relative to StO2 (p < 0.001). After 12 weeks of training, an improvement in the deoxygenation rate was observed in both groups (p = 0.002), but with a greater magnitude in the CG (p = 0.017). Only the CG presented an increase in time to reach the lowest StO2 on the treadmill after the intervention (p = 0.010). The traditional aerobic training was superior to the modified training in relation to the improvement of muscle metabolism in patients with PAD.


2019 ◽  
Vol 8 (12) ◽  
pp. 2125 ◽  
Author(s):  
Mégane Pizzimenti ◽  
Marianne Riou ◽  
Anne-Laure Charles ◽  
Samy Talha ◽  
Alain Meyer ◽  
...  

Peripheral arterial disease (PAD) is a frequent and serious condition, potentially life-threatening and leading to lower-limb amputation. Its pathophysiology is generally related to ischemia-reperfusion cycles, secondary to reduction or interruption of the arterial blood flow followed by reperfusion episodes that are necessary but also—per se—deleterious. Skeletal muscles alterations significantly participate in PAD injuries, and interestingly, muscle mitochondrial dysfunctions have been demonstrated to be key events and to have a prognosis value. Decreased oxidative capacity due to mitochondrial respiratory chain impairment is associated with increased release of reactive oxygen species and reduction of calcium retention capacity leading thus to enhanced apoptosis. Therefore, targeting mitochondria might be a promising therapeutic approach in PAD.


2009 ◽  
Vol 96 (9) ◽  
pp. 990-998 ◽  
Author(s):  
N. Khandanpour ◽  
M. P. Armon ◽  
B. Jennings ◽  
P. M. Finglas ◽  
G. Willis ◽  
...  

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