Meta-Analysis on the Effects of Transcranial Direct Current Stimulation on Naming of Elderly with Primary Progressive Aphasia

Purpose: This study aimed to conduct a qualitative evaluation by synthesizing previous studies on the effect of transcranial direct current stimulation (tDCS) on primary progressive aphasia (PPA)’s naming ability and prove the effects of tDCS mediation on PPA naming using meta-analysis. Methods: This study searched literature published from January 2000 to July 2019 using four academic databases (i.e., PubMed, Web of Science, MEDLINE, and Cochrane Library). The final seven publications were systematically evaluated and meta-analysis was conducted for two papers. The effect size was estimated by a standard mean difference (SMD) using Hedge’s g, and the significance of effect size was confirmed using the 95% confidence interval. Results: The results of seven previous studies’ quality assessments ranged from 15 to 26, which were rated above adequate. The results of the meta-analysis showed that the effect size was 0.82 (95% CI: 0.16–1.47), which was a significant ‘large effect’. Conclusions: This meta-analysis proved that tDCS intervention significantly improved the naming performance of PPA. Future studies must confirm the effects of tDCS on naming intervention by using meta-analysis including many RCT studies.

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Transcranial Direct Current Stimulation in Treating Spelling Deficits in Primary Progressive Aphasia

Procedia - Social and Behavioral Sciences ◽

10.1016/j.sbspro.2013.09.102 ◽

2013 ◽

Vol 94 ◽

pp. 207-208

Author(s):

K. Tsapkini ◽

A. Hillis

Keyword(s):

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Primary Progressive Aphasia ◽

Progressive Aphasia ◽

Direct Current Stimulation ◽

Primary Progressive

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Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study

Brain and Language ◽

10.1016/j.bandl.2016.05.007 ◽

2016 ◽

Vol 162 ◽

pp. 35-41 ◽

Cited By ~ 20

Author(s):

Felix Gervits ◽

Sharon Ash ◽

H. Branch Coslett ◽

Katya Rascovsky ◽

Murray Grossman ◽

...

Keyword(s):

Pilot Study ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Primary Progressive Aphasia ◽

Open Label ◽

Progressive Aphasia ◽

Direct Current Stimulation ◽

Primary Progressive

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Transcranial Direct Current Stimulation for Parkinson's Disease: A Systematic Review and Meta-Analysis

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.746797 ◽

2021 ◽

Vol 13 ◽

Author(s):

Xiang Liu ◽

Huiyu Liu ◽

Zicai Liu ◽

Jinzhu Rao ◽

Jing Wang ◽

...

Keyword(s):

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Function ◽

Direct Current ◽

Effect Size ◽

Transcranial Direct Current Stimulation ◽

Meta Analysis ◽

Cochrane Library ◽

Direct Current Stimulation

Background: Parkinson's disease is a common neurodegenerative disorder with motor and non-motor symptoms. Recently, as adjuvant therapy, transcranial direct current stimulation (tDCS) has been shown to improve the motor and non-motor function of patients with Parkinson's disease (PD). This systematic review aimed to evaluate the existing evidence for the efficacy of tDCS for PD. We included English databases (PubMed, the Cochrane Library, Embase, and Web of Science) and Chinese databases [Wanfang database, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and China Biology Medicine (CBM)] without restricting the year of publication. Twenty-one tDCS studies, with a total of 736 participants, were included in the analysis. Two independent researchers extracted the data and characteristics of each study. There was a significant pooled effect size (−1.29; 95% CI = −1.60, −0.98; p < 0.00001; I2 = 0%) in the Unified PD Rating Scale (UPDRS) I and the Montreal cognitive assessment (SMD = 0.87, 95% CI = 0.50 to 1.24; p < 0.00001; I2 = 0%). The poor effect size was observed in the UPDRS III scores (SMD = −0.13; 95% CI = −0.64, 0.38; p = 0.61; I2 = 77%), and similar results were observed for the timed up and go (TUG) test, Berg balance scale, and gait assessment. The results of this meta-analysis showed that there was insufficient evidence that tDCS improves the motor function of patients with PD. However, tDCS seemed to improve their cognitive performance. Further multicenter research with a larger sample size is needed. In addition, future research should focus on determining the tDCS parameters that are most beneficial to the functional recovery of patients with PD.

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