scholarly journals Characteristics of Psychosocial Factors in Liver Transplantation Candidates with Alcoholic Liver Disease before Transplantation: A Retrospective Study in a Single Center in Taiwan

2020 ◽  
Vol 17 (22) ◽  
pp. 8696
Author(s):  
Yu-Ming Chen ◽  
Tien-Wei Yu ◽  
Chih-Chi Wang ◽  
Kuang-Tzu Huang ◽  
Li-Wen Hsu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Alcohol Use ◽  
Family Functioning ◽  
Alcoholic Liver Disease ◽  
Rating Scale ◽  
Depression Scale ◽  
Hamilton Depression Rating Scale ◽  
Alcohol Abstinence ◽  
Abstinence Period

Liver transplantation (LT) is an essential treatment for end-stage alcoholic liver disease (ALD). The patients’ psychosocial condition plays a vital role in post-transplantation prognosis. A survey of the candidates’ psychosocial wellbeing is necessary before LT. This study aims to investigate the psychosocial characteristics, including the depression degree, family function, alcohol use duration, and alcohol abstinence period, of LT candidates with ALD. In addition, 451 candidates for LT due to ALD were enrolled. They received psychosocial evaluations, including depression scale (Hamilton depression rating scale) and family functioning assessment (adaptability, partnership, growth, affection, resolve (APGAR) index). The test scores were analyzed according to age, alcohol use duration, and alcohol abstinence period. The Hamilton depression rating scale (HAM-D) score and the family APGAR index score differentiated significantly according to the age, alcohol use duration, and abstinence period of the LT candidates. The patients with shorter alcohol use duration tended to have more severe depressive symptoms and poorer family support. The younger patients showed a significantly shorter abstinence period, more severe depression, and poorer family functioning than older patients. The younger ALD patients and patients with shorter alcohol use duration showed an increased severity of depression before transplantation. They need more mental health care over time.

scholarly journals Alcohol Use Relapse Following Liver Transplantation for Alcoholic Liver Disease

2019 ◽  
Vol 24 ◽  
pp. 359-366 ◽  
Author(s):  
Lubomir Skladany ◽  
Svetlana Adamcova Selcanova ◽  
Tomas Koller
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Alcohol Use ◽  
Alcoholic Liver Disease

scholarly journals Psychosocial characteristics of alcoholic and non-alcoholic liver disease recipient candidates in liver transplantation: a prospective observational study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Masato Shizuku ◽  
Hiroyuki Kimura ◽  
Hideya Kamei ◽  
Shinichi Kishi ◽  
Tatsuya Tokura ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Observational Study ◽  
Alcoholic Liver Disease ◽  
Prospective Observational Study ◽  
Short Form ◽  
Depression Scale ◽  
Preoperative Period ◽  
Psychosocial Characteristics ◽  
Significant Difference

Abstract Background There are long-standing controversies about the transplant indications for alcoholic liver disease (ALD), because of the recognition that ALD is fundamentally self-inflicted. However, it is unclear whether psychosocial characteristics of ALD are different from that of non-alcoholic liver disease (NALD) in the selection of liver transplantation (LT) recipients. We aimed to clarify the psychosocial characteristics of ALD recipients (ALD-R)/ALD recipient candidates (ALD-RC) and NALD recipients (NALD-R)/ NALD recipient candidates (NALD-RC). Methods From 2011 to 2019, 75 patients were enrolled in this prospective observational study (ALD-RC, n = 19; NALD-RC, n = 56), LT were carried out as follow; ALD-R, n = 6; NALD-R, n = 52. We evaluated psychosocial characteristics in the preoperative period and 3, 12 months after LT (ALD-R, n = 3/3; NALD-R, n = 28/25). The following scales were used to evaluate psychosocial characteristics: Visual Analogue Scale, Alcohol Use Disorders Identification Test, Hospital Anxiety and Depression Scale, Beck Depression Inventory, Brief Evaluation of Medication Influences and Beliefs, Social Support Questionnaire (SSQ), Temperament and Character Inventory, Parental Bonding Instrument (PBI), the Short Form Health Survey (SF-36). Results When evaluating on the basis of abstinence rule, a comparison of ALD-RC and NALD-RC in the preoperative period identified similar patterns of psychosocial characteristics, except that the NALD-RC scored higher on the PBI item “overprotection from mother” (P < 0.05). The only significant difference between ALD-R and NALD-R after liver transplantation was in SSQ scores at 3 months. Conclusion The psychosocial characteristics of ALD-RC and NALD-RC may be similar when evaluated on the basis of Japan’s abstinence rule. This result also imply that the psychosocial characteristics of ALD-RC may differ from the previously reported psychosocial characteristics of alcohol dependent patients. These findings have the potential to provide helpful information for the evaluation of ALD-RC.

scholarly journals Phosphatidylethanol for Monitoring Alcohol Use in Liver Transplant Candidates: An Observational Study

2020 ◽  
Vol 9 (9) ◽  
pp. 3060 ◽  
Author(s):  
Pablo Barrio ◽  
Antoni Gual ◽  
Anna Lligoña ◽  
Lidia Teixidor ◽  
Wolfgang Weinmann ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liver Transplantation ◽  
Liver Disease ◽  
Alcohol Use ◽  
Observational Study ◽  
Alcoholic Liver Disease ◽  
False Negative ◽  
Complex Process ◽  
Self Reports ◽  
Transplant Candidates

Liver transplantation remains an essential procedure for many patients suffering from alcoholic liver disease. Alcohol use monitoring remains paramount all through the stages of this complex process. Direct alcohol biomarkers, with improved specificity and sensibility, should replace traditional indirect markers. Phosphatidylethanol (PEth) has been recently tested in alcoholic liver disease patients, but more evidence is needed, especially in comparison with other direct biomarkers. We conducted an observational study among patients awaiting liver transplantation. We analyzed Peth in blood, ethylglucuronide (EtG) in hair and urine and ethylsulphate (EtS) in urine, using mass spectrometry methods. In addition, transaminases, and self-reports were analyzed. A total of 50 patients were included (84% men, mean age 59 years (SD = 6)). 18 patients (36%) screened positive for any marker. Self-reports were positive in 3 patients. EtS was the biomarker with more positive screens. It also was the most frequently exclusive biomarker, screening positive in 7 patients who were negative for all other biomarkers. PEth was positive in 5 patients, being the only positive biomarker in 2 patients. It showed a false negative in a patient admitting alcohol use the previous week and screening positive for EtG and EtS. Hair EtG was positive in 3 patients who had negative Peth, EtG. EtG did not provide any exclusive positive result.A combination of biomarkers seems to be the best option to fully ascertain abstinence in this population. Our study suggest EtS might also play a significant role.

scholarly journals Risk of alcohol use relapse after liver transplantation for alcoholic liver disease

2017 ◽  
Vol 23 (5) ◽  
pp. 869 ◽  
Author(s):  
Yasuharu Onishi ◽  
Hiroyuki Kimura ◽  
Tomohide Hori ◽  
Shinichi Kishi ◽  
Hideya Kamei ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Alcohol Use ◽  
Alcoholic Liver Disease
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