scholarly journals Clusters of Alcohol Use Disorders Diagnostic Criteria and Predictors of Alcohol Use After Liver Transplantation for Alcoholic Liver Disease

2008 ◽  
Vol 49 (4) ◽  
pp. 332-340 ◽  
Author(s):  
Andrea DiMartini ◽  
Mary Amanda Dew ◽  
Mary Grace Fitzgerald ◽  
Paulo Fontes
Author(s):  
Shaikh GM ◽  
◽  
Gupta GL ◽  

Alcohol Use Disorders (AUD) originates due to heavy and uncontrolled drinking of alcohol. It is one of the most prevalent mental disorders, which predominantly affects men globally. In the review article alcohol use disorders and several risk factors like gender, drinking habit, genetic differences, and obesity Hepatitis C virus has been described for the provocation of intestinal dysbiosis. Alcoholic Liver Disease (ALD) is a spectrum of diseases from steatohepatitis to Hepatocellular Carcinoma (HCC). Due to dysbiosis, there are microbial changes also taking place in the liver and it further worsens the conditions. Treatment involves treating gut dysbiosis and altered balance of the micro-organism. The treatment strategy of ALD may also involve a non-dietary approach or dietary approach or by microbiota modulation.


2019 ◽  
Vol 24 ◽  
pp. 359-366 ◽  
Author(s):  
Lubomir Skladany ◽  
Svetlana Adamcova Selcanova ◽  
Tomas Koller

2019 ◽  
Vol 23 (1) ◽  
pp. 55-69 ◽  
Author(s):  
Jessica L. Mellinger ◽  
Gerald Scott Winder

Author(s):  
Yu-Ming Chen ◽  
Tien-Wei Yu ◽  
Chih-Chi Wang ◽  
Kuang-Tzu Huang ◽  
Li-Wen Hsu ◽  
...  

Liver transplantation (LT) is an essential treatment for end-stage alcoholic liver disease (ALD). The patients’ psychosocial condition plays a vital role in post-transplantation prognosis. A survey of the candidates’ psychosocial wellbeing is necessary before LT. This study aims to investigate the psychosocial characteristics, including the depression degree, family function, alcohol use duration, and alcohol abstinence period, of LT candidates with ALD. In addition, 451 candidates for LT due to ALD were enrolled. They received psychosocial evaluations, including depression scale (Hamilton depression rating scale) and family functioning assessment (adaptability, partnership, growth, affection, resolve (APGAR) index). The test scores were analyzed according to age, alcohol use duration, and alcohol abstinence period. The Hamilton depression rating scale (HAM-D) score and the family APGAR index score differentiated significantly according to the age, alcohol use duration, and abstinence period of the LT candidates. The patients with shorter alcohol use duration tended to have more severe depressive symptoms and poorer family support. The younger patients showed a significantly shorter abstinence period, more severe depression, and poorer family functioning than older patients. The younger ALD patients and patients with shorter alcohol use duration showed an increased severity of depression before transplantation. They need more mental health care over time.


2020 ◽  
Vol 9 (9) ◽  
pp. 3060 ◽  
Author(s):  
Pablo Barrio ◽  
Antoni Gual ◽  
Anna Lligoña ◽  
Lidia Teixidor ◽  
Wolfgang Weinmann ◽  
...  

Liver transplantation remains an essential procedure for many patients suffering from alcoholic liver disease. Alcohol use monitoring remains paramount all through the stages of this complex process. Direct alcohol biomarkers, with improved specificity and sensibility, should replace traditional indirect markers. Phosphatidylethanol (PEth) has been recently tested in alcoholic liver disease patients, but more evidence is needed, especially in comparison with other direct biomarkers. We conducted an observational study among patients awaiting liver transplantation. We analyzed Peth in blood, ethylglucuronide (EtG) in hair and urine and ethylsulphate (EtS) in urine, using mass spectrometry methods. In addition, transaminases, and self-reports were analyzed. A total of 50 patients were included (84% men, mean age 59 years (SD = 6)). 18 patients (36%) screened positive for any marker. Self-reports were positive in 3 patients. EtS was the biomarker with more positive screens. It also was the most frequently exclusive biomarker, screening positive in 7 patients who were negative for all other biomarkers. PEth was positive in 5 patients, being the only positive biomarker in 2 patients. It showed a false negative in a patient admitting alcohol use the previous week and screening positive for EtG and EtS. Hair EtG was positive in 3 patients who had negative Peth, EtG. EtG did not provide any exclusive positive result.A combination of biomarkers seems to be the best option to fully ascertain abstinence in this population. Our study suggest EtS might also play a significant role.


2017 ◽  
Vol 23 (5) ◽  
pp. 869 ◽  
Author(s):  
Yasuharu Onishi ◽  
Hiroyuki Kimura ◽  
Tomohide Hori ◽  
Shinichi Kishi ◽  
Hideya Kamei ◽  
...  

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