scholarly journals Biological Properties of Calcium Phosphate Bioactive Glass Composite Bone Substitutes: Current Experimental Evidence

2019 ◽  
Vol 20 (2) ◽  
pp. 305 ◽  
Author(s):  
Maria Karadjian ◽  
Christopher Essers ◽  
Stefanos Tsitlakidis ◽  
Bruno Reible ◽  
Arash Moghaddam ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Calcium Phosphates ◽  
Donor Site ◽  
Bone Substitutes ◽  
Biological Properties ◽  
Recent Experimental Data ◽  
Bone Substitute Materials ◽  
Autologous Bone ◽  
Substitute Materials ◽  
Composite Bone

Standard treatment for bone defects is the biological reconstruction using autologous bone—a therapeutical approach that suffers from limitations such as the restricted amount of bone available for harvesting and the necessity for an additional intervention that is potentially followed by donor-site complications. Therefore, synthetic bone substitutes have been developed in order to reduce or even replace the usage of autologous bone as grafting material. This structured review focuses on the question whether calcium phosphates (CaPs) and bioactive glasses (BGs), both established bone substitute materials, show improved properties when combined in CaP/BG composites. It therefore summarizes the most recent experimental data in order to provide a better understanding of the biological properties in general and the osteogenic properties in particular of CaP/BG composite bone substitute materials. As a result, BGs seem to be beneficial for the osteogenic differentiation of precursor cell populations in-vitro when added to CaPs. Furthermore, the presence of BG supports integration of CaP/BG composites into bone in-vivo and enhances bone formation under certain circumstances.

scholarly journals New Oral Surgery Materials for Bone Reconstruction—A Comparison of Five Bone Substitute Materials for Dentoalveolar Augmentation

Materials ◽  
2020 ◽  
Vol 13 (13) ◽  
pp. 2935 ◽  
Author(s):  
Marcin Kozakiewicz ◽  
Tomasz Wach
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Substitute ◽  
Oral Surgery ◽  
Calcium Phosphates ◽  
Bone Replacement ◽  
Living Bone ◽  
Bone Substitute Materials ◽  
Occurrence Matrix ◽  
Radiological Image ◽  
Substitute Materials

This article presents a comparison of bone replacement materials in terms of their ability to produce living bone image at the place of their implantation. Five bone replacement materials are compared (Osteovit—porous collagen, Cerasorb Foam—collagen scaffolding of synthetic β tricalcium phosphate, Osbone—synthetic hydroxyapatite, Endobone—deproteinized bovine-derived cancellous bone hydroxyapatite, and Cerasorb—synthetic β tricalcium phosphate). Intraoral radiographs are taken immediately after implantation and 12 months later. The texture analysis was performed to assess (texture index, TI) the level of structure chaos (entropy) in relation to the presence of longitudinal elements visible in radiographs (run length emphasis moment). The reference ratio of the chaotic trabecular pattern (Entropy) to the number of longitudinal structures, i.e., trabeculae (LngREmph), is 176:100 (i.e., 1.76 ± 0.28). Radiological homogeneity immediately after the implantation procedure is a result of the similar shape of its particles (Osbone, Endobone and Cerasorb) or radiolucency (Osteovit, Cerasorb Foam). The particles visible in radiographs were similar in the LngREmph parameters applied to the reference bone, but not in the co-occurrence matrix features. The TI for Osteovit during a 12-month follow-up period changed from 1.55 ± 0.26 to 1.48 ± 0.26 (p > 0.05), for Cerasorb Foam from 1.82 ± 0.27 to 1.63 ± 0.24 (p < 0.05), for Osbone from 1.97 ± 0.31 to 1.74 ± 0.30 (p < 0.01), and for Endobone from 1.86 ± 0.25 to 1.84 ± 0.25 (p > 0.05), The observed structure in the radiological image of bone substitute materials containing calcium phosphates obtains the characteristics of a living bone image after twelve months.

scholarly journals Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

2021 ◽  
Vol 6 (2) ◽  
pp. 346-360 ◽  
Author(s):  
Duoyi Zhao ◽  
Tongtong Zhu ◽  
Jie Li ◽  
Liguo Cui ◽  
Zhiyu Zhang ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Glycolic Acid ◽  
Bone Substitute Materials ◽  
Substitute Materials ◽  
Composite Bone

Synthesis of Porous Metakaolin Geopolymer as Bone Substitute Materials

2019 ◽  
Vol 829 ◽  
pp. 182-187
Author(s):  
Yanwar Faza ◽  
Andrie Harmaji ◽  
Veni Takarini ◽  
Zulia Hasratiningsih ◽  
Arief Cahyanto
Keyword(s):  
Aluminum Powder ◽  
Bone Substitute ◽  
Bone Substitutes ◽  
Spongy Bone ◽  
X Ray Diffraction ◽  
Naoh Solution ◽  
Bone Substitute Materials ◽  
Alkaline Activator ◽  
Metakaolin Geopolymer ◽  
Substitute Materials

Metakaolin-based porous geopolymer had been successfully developed using aluminum powder by creating bubbles in the structure. These structures were required to mimic the spongy bone thus may be applied as bone substitute materials. It was conducted by adding the aluminum powder in the mixture of Metakaolin (MK) and Alkaline Activator (AA) (NaOH solution and sodium silicate) with ratio 1:1, 1:1,5, 1: 2, 1:2,5 and 1:3 then namely sample A-E respectively. The slurry was then poured into mold 30 x 30 x 30 mm3. Samples were let harden and heated in the oven 80°C for 4 hours prior to demolding. Scanning Electron Microscope (SEM) and X-ray diffraction (XRD) were used to observe the morphology of porosity resulted in the samples and to characterize the crystallinity of the samples. The results showed porous metakaolin geopolymer of sample A had the most similarity with the human spongy bone (80-400 µm). Along with an increase in the amount of AA, crystallinity of albite show a decrease of intensity. This study concluded the porous metakaolin geopolymer obtained was potential to be used as a bone substitutes materials.

Bone Substitute Materials in Modern Dentistry

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Andrius Geguzis ◽  
Inesa Astramskaite ◽  
Dovile Gabseviciute
Keyword(s):  
Bone Substitute ◽  
Bone Substitute Materials ◽  
Substitute Materials

In vitro effects of particulate bone substitute materials on the resorption activity of human osteoclasts

2017 ◽  
Vol 34 ◽  
pp. 291-306 ◽  
Author(s):  
G Russmueller ◽  
◽  
L Winkler ◽  
R Lieber ◽  
R Seemann ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Bone Substitute Materials ◽  
In Vitro Effects ◽  
Substitute Materials ◽  
Human Osteoclasts
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