scholarly journals Postoperative Changes in Pulmonary Function after Valve Surgery: Oxygenation Index Early after Cardiopulmonary Is a Predictor of Postoperative Course

2021 ◽  
Vol 10 (15) ◽  
pp. 3262
Author(s):  
Tomohiro Murata ◽  
Motohiro Maeda ◽  
Ryosuke Amitani ◽  
Atsushi Hiromoto ◽  
Makoto Shirakawa ◽  
...  
Keyword(s):  
Fast Track ◽  
Oxygenation Index ◽  
Valve Surgery ◽  
Blood Gas ◽  
Cardiac Anesthesia ◽  
Functional Changes ◽  
Ventilation Time ◽  
Postoperative Changes ◽  
Hospital Stays ◽  
Blood Gas Analyses

Objective: To determine pulmonary functional changes that predict early clinical outcomes in valve surgery requiring long cardiopulmonary bypass (CPB). Methods: This retrospective study included 225 consecutive non-emergency valve surgeries with fast-track cardiac anesthesia between January 2014 and March 2020. Blood gas analyses before and 0, 2, 4, 8, and 14 h after CPB were investigated. Results: Median age and EuroSCORE II were 71.0 years (25–75 percentile: 59.5–77.0) and 2.46 (1.44–5.01). Patients underwent 96 aortic, 106 mitral, and 23 combined valve surgeries. The median CPB time was 151 min (122–193). PaO2/FiO2 and AaDO2/PaO2 significantly deteriorated two hours, but not immediately, after CPB (both p < 0.0001). Decreased PaO2/FiO2 and AaDO2/PaO2 were correlated with ventilation time (r2 = 0.318 and 0.435) and intensive care unit (ICU) (r2 = 0.172 and 0.267) and hospital stays (r2 = 0.164 and 0.209). Early and delayed extubations (<6 and >24 h) were predicted by PaO2/FiO2 (377.2 and 213.1) and AaDO2/PaO2 (0.683 and 1.680), measured two hours after CPB with acceptable sensitivity and specificity (0.700–0.911 and 0.677–0.859). Conclusions: PaO2/FiO2 and AaDO2/PaO2 two hours after CPB were correlated with ventilation time and lengths of ICU and hospital stays. These parameters suitably predicted early and delayed extubations.

scholarly journals Blood gas analyses and other components involved in the acid–base metabolism of rats infected by Trypanosoma evansi

2015 ◽  
Vol 6 (6) ◽  
pp. 1079-1082
Author(s):  
Matheus D. Baldissera ◽  
Rodrigo A. Vaucher ◽  
Camila B. Oliveira ◽  
Virginia C. Rech ◽  
Michele R. Sagrillo ◽  
...  
Keyword(s):  
Trypanosoma Evansi ◽  
Blood Gas ◽  
Acid Base ◽  
Blood Gas Analyses

Blood Gas Analyses

Medcin ◽  
1997 ◽  
pp. 176-176
Author(s):  
Peter S. Goltra
Keyword(s):  
Blood Gas ◽  
Blood Gas Analyses

scholarly journals The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19

2021 ◽  
Vol 12 ◽  
Author(s):  
Thomas Gille ◽  
Lucile Sesé ◽  
Eric Aubourg ◽  
Emmanuelle E. Fabre ◽  
Florence Cymbalista ◽  
...  
Keyword(s):  
Time Course ◽  
Blood Gas ◽  
Dissociation Curve ◽  
Cell Disease ◽  
Single Center Study ◽  
Significant Difference ◽  
Blood Gas Analyses ◽  
Hb Concentration ◽  
Center Study ◽  
Positive Controls

Background: A computational proteomic analysis suggested that SARS-CoV-2 might bind to hemoglobin (Hb). The authors hypothesized that this phenomenon could result in a decreased oxygen (O2) binding and lead to hemolytic anemia as well. The aim of this work was to investigate whether the affinity of Hb for O2 was altered during COVID-19.Methods: In this retrospective, observational, single-center study, the blood gas analyses of 100 COVID-19 patients were compared to those of 100 non-COVID-19 patients. Fifty-five patients with carboxyhemoglobin (HbCO) ≥8% and 30 with sickle cell disease (SCD) were also included (“positive controls” with abnormal Hb affinity). P50 was corrected for body temperature, pH, and PCO2.Results: Patients did not differ statistically for age or sex ratio in COVID-19 and non-COVID-19 groups. Median P50 at baseline was 26 mmHg [25.2–26.8] vs. 25.9 mmHg [24–27.3], respectively (p = 0.42). As expected, P50 was 22.5 mmHg [21.6–23.8] in the high HbCO group and 29.3 mmHg [27–31.5] in the SCD group (p &lt; 0.0001). Whatever the disease severity, samples from COVID-19 to non-COVID-19 groups were distributed on the standard O2-Hb dissociation curve. When considering the time-course of P50 between days 1 and 18 in both groups, no significant difference was observed. Median Hb concentration at baseline was 14 g.dl–1 [12.6–15.2] in the COVID-19 group vs. 13.2 g.dl–1 [11.4–14.7] in the non-COVID-19 group (p = 0.006). Among the 24 COVID-19 patients displaying anemia, none of them exhibited obvious biological hemolysis.Conclusion: There was no biological argument to support the hypothesis that SARS-CoV-2 could alter O2 binding to Hb.

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