The Prognostic Value of 18F-FDG PET Imaging at Staging in Patients with Malignant Pleural Mesothelioma: A Literature Review

Malignant pleural mesothelioma (MPM) is an aggressive malignancy, frequently diagnosed at locally-advanced/metastatic stages. Due to a very poor prognosis and limited treatment options, the need to identify new prognostic markers represents a great clinical challenge. The prognostic role of metabolic information derived from Positron Emission Tomography (PET) with 18F-Fluoro-deoxy-glucose (18F-FDG) has been investigated in different MPM settings, however with no definitive consensus. In this comprehensive review, the prognostic value of FDG-PET imaging exclusively performed at staging in MPM patients was evaluated, conducting a literature search on PubMed/MEDLINE from 2010 to 2020. From the 19 selected studies, despite heterogeneity in several aspects, staging FDG-PET imaging emerges as a valuable prognostic biomarker, with higher tumor uptake predictive of worse prognosis, and with volumetric metabolic parameters like Metabolic Tumor Volume, (MTV) and Total Lesion Glycolisis (TLG) performing better than SUVmax. However, PET uptake parameters were not always confirmed as independent prognostic factors, especially in patients previously treated with pleurodesis and with a non-epithelioid histotype. Future prospective studies in larger and clinically homogeneous populations, and using more standardized methods of PET images analysis, are needed to further validate the value of staging FDG-PET in the prognostic MPM stratification, with a potential impact on better patient-tailored treatment planning, in the perspective of personalized medicine.

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79 Use of 18F-FDG PET imaging in staging and prediction of survival for malignant pleural mesothelioma (MPM)

Lung Cancer ◽

10.1016/s0169-5002(07)70155-1 ◽

2006 ◽

Vol 54 ◽

pp. S19 ◽

Cited By ~ 4

Author(s):

A.K. Nowak ◽

R.J. Francis ◽

M.J. Byrne ◽

A.A. van der Schaaf ◽

J. Boucek ◽

...

Keyword(s):

Malignant Pleural Mesothelioma ◽

Pet Imaging ◽

Fdg Pet ◽

Pleural Mesothelioma ◽

Prediction Of Survival ◽

18F Fdg

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Prognostic Value of 18F-FDG PET/CT in Patients with Malignant Pleural Mesothelioma

Molecular Imaging and Biology ◽

10.1007/s11307-009-0203-6 ◽

2009 ◽

Vol 11 (6) ◽

pp. 473-479 ◽

Cited By ~ 28

Author(s):

S. T. Lee ◽

M. Ghanem ◽

R. A. Herbertson ◽

S. U. Berlangieri ◽

A. J. Byrne ◽

...

Keyword(s):

Malignant Pleural Mesothelioma ◽

Fdg Pet ◽

Prognostic Value ◽

Pleural Mesothelioma ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Nuclear Medicine and Molecular Imaging ◽

10.1007/s13139-010-0063-7 ◽

2010 ◽

Vol 45 (1) ◽

pp. 43-51 ◽

Cited By ~ 29

Author(s):

Kyu-Ho Choi ◽

Ie Ryung Yoo ◽

Eun Ji Han ◽

Yeon Sil Kim ◽

Gi Won Kim ◽

...

Keyword(s):

Fdg Pet ◽

Prognostic Value ◽

Tumor Volume ◽

Locally Advanced ◽

Metabolic Tumor Volume ◽

Squamous Cell Carcinomas ◽

Advanced Head ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation

Blood ◽

10.1182/blood-2002-12-3842 ◽

2003 ◽

Vol 102 (1) ◽

pp. 53-59 ◽

Cited By ~ 172

Author(s):

Karoline Spaepen ◽

Sigrid Stroobants ◽

Patrick Dupont ◽

Peter Vandenberghe ◽

Johan Maertens ◽

...

Keyword(s):

Fdg Pet ◽

Prognostic Value ◽

High Dose Chemotherapy ◽

Emission Tomography ◽

High Dose ◽

Conventional Imaging ◽

Positron Emission ◽

Fdg Pet Scan ◽

18F Fdg ◽

Fluorine 18 Fluorodeoxyglucose

Abstract The study assessed the prognostic value of fluorine 18-fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) after salvage chemotherapy before high-dose chemotherapy with stem cell transplantation (HDT/SCT) in patients with induction failure or relapsing chemosensitive lymphoma. Retrospective analysis of the clinical and conventional imaging data of 60 patients scheduled for HDT/SCT was performed in parallel with the analysis of the [18F]FDG-PET results. To determine the ability of [18F]FDG-PET to predict clinical outcome, PET images were reread without knowledge of conventional imaging and clinical history. Presence or absence of abnormal [18F]FDG uptake was related to progression-free survival (PFS) and overall survival (OS) using Kaplan-Meier survival analysis. Thirty patients showed a negative [18F]FDG-PET scan before HDT/SCT; 25 of those remained in complete remission, with a median follow-up of 1510 days. Two patients died due to a treatment-related mortality but without evidence of recurrent disease at that time (228-462 days). Only 3 patients had a relapse (median PFS, 1083 days) after a negative [18F]FDG-PET scan. Persistent abnormal [18F]FDG uptake was seen in 30 patients and 26 progressed (median PFS, 402 days); of these 26, 16 died from progressive disease (median OS, 408 days). Four patients are still in complete remission after a positive scan. Comparison between groups indicated a statistically significant association between [18F]FDG-PET findings and PFS (P < .000001) and OS (P < .00002). [18F]FDG-PET has an important prognostic role in the pretransplantation evaluation of patients with lymphoma and enlarges the concept of chemosensitivity used to select patients for HDT/SCT. (Blood. 2003;102:53-59)

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Cervical Cancer: Associations between Metabolic Parameters and Whole Lesion Histogram Analysis Derived from Simultaneous 18F-FDG-PET/MRI

Contrast Media & Molecular Imaging ◽

10.1155/2018/5063285 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Hans-Jonas Meyer ◽

Sandra Purz ◽

Osama Sabri ◽

Alexey Surov

Keyword(s):

Cervical Cancer ◽

Fdg Pet ◽

Metabolic Tumor Volume ◽

Total Lesion Glycolysis ◽

Histogram Analysis ◽

Whole Body ◽

Standardized Uptake Values ◽

Positron Emission ◽

18F Fdg ◽

Magnetic Resonance Imaging Mri

Multimodal imaging has been increasingly used in oncology, especially in cervical cancer. By using a simultaneous positron emission (PET) and magnetic resonance imaging (MRI, PET/MRI) approach, PET and MRI can be obtained at the same time which minimizes motion artefacts and allows an exact imaging fusion, which is especially important in anatomically complex regions like the pelvis. The associations between functional parameters from MRI and 18F-FDG-PET reflecting different tumor aspects are complex with inconclusive results in cervical cancer. The present study correlates histogram analysis and 18F-FDG-PET parameters derived from simultaneous FDG-PET/MRI in cervical cancer. Overall, 18 female patients (age range: 32–79 years) with histopathologically confirmed squamous cell cervical carcinoma were retrospectively enrolled. All 18 patients underwent a whole-body simultaneous 18F-FDG-PET/MRI, including diffusion-weighted imaging (DWI) using b-values 0 and 1000 s/mm2. Apparent diffusion coefficient (ADC) histogram parameters included several percentiles, mean, min, max, mode, median, skewness, kurtosis, and entropy. Furthermore, mean and maximum standardized uptake values (SUVmean and SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were estimated. No statistically significant correlations were observed between SUVmax or SUVmean and ADC histogram parameters. TLG correlated inversely with p25 (r=−0.486,P=0.041), p75 (r=−0.490,P=0.039), p90 (r=−0.513,P=0.029), ADC median (r=−0.497,P=0.036), and ADC mode (r=−0.546,P=0.019). MTV also showed significant correlations with several ADC parameters: mean (r=−0.546,P=0.019), p10 (r=−0.473,P=0.047), p25 (r=−0.569,P=0.014), p75 (r=−0.576,P=0.012), p90 (r=−0.585,P=0.011), ADC median (r=−0.577,P=0.012), and ADC mode (r=−0.597,P=0.009). ADC histogram analysis and volume-based metabolic 18F-FDG-PET parameters are related to each other in cervical cancer.

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