scholarly journals Personalized Medicine in Autoimmune Diseases

2021 ◽  
Vol 11 (11) ◽  
pp. 1181
Author(s):  
Roberto Díaz-Peña

Autoimmune diseases are multifactorial disorders caused by both genetic and environmental factors and without a known cure [...]

Genes ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1937
Author(s):  
Malgorzata Gabriela Wasniewska ◽  
Artur Bossowski

Autoimmune diseases (ADs) are characterized by a multifactorial etiology, in which genetic and environmental factors are responsible for the loss of immunological tolerance [...]


2019 ◽  
Author(s):  
Tamia A Harris ◽  
Shai Bel

Autoimmune diseases are complex illnesses in which the body’s immune system attacks its own healthy tissues. These diseases, which can be fatal, gravely impact the quality of life of those afflicted by them with no cure currently available. The exact etiology of autoimmune diseases is not completely clear. Biomedical research has revealed that both genetic and environmental factors contribute to the development and progression of these diseases. Nevertheless, genetic and environmental factors alone cannot explain a large proportion of cases, leading to the possibility that the two factors interact in driving disease onset. Understanding how genetic and environmental factor influence host physiology in a manner that leads to the development of autoimmune diseases can reveal the mechanisms by which these diseases manifest, and bring us closer to finding a cure for them. In this chapter, we will review the current research of genetic/environmental interactions that contribute to development of autoimmune diseases, with an emphasis on interactions between the host and the multitudes of microbes that inhabit it, the microbiota.


2019 ◽  
pp. 165-190
Author(s):  
José Carlos Pinto Da Costa

Precision, or personalized, medicine (PM) is a ground-breaking approach to medical care which aims to predict, prevent and treat diseases by studying, on an individual scale, the pathogenic potential of the association between genetic and environmental factors. As one of the most important outcomes of biotechnological research, PM is generated in the lab. Nonetheless, the impacts of PM will be observed outside of the lab, namely, on the modification of population’s patterns of use and access to healthcare. Taking PM as object of study, anthropologists are challenged to make a double reflection. The first consists in understanding which peculiarities an ethnography should have to grasp engineers’ and other experts’ underlying modes of knowing and doing inside de lab. The second, more analytical, consists in identifying the indicators revealed by that ethnography which may promote an interpretation of how these modes simultaneously mirror and resonate a given cultural will located both upstream and downstream the lab — from and to outside of it. The purpose of this paper is to reflect on the hypothesis stressing that an ethnographic collaboration might configure an effective way of doing this.


2019 ◽  
Author(s):  
Tamia A Harris ◽  
Shai Bel

Autoimmune diseases are complex illnesses in which the body’s immune system attacks its own healthy tissues. These diseases, which can be fatal, gravely impact the quality of life of those afflicted by them with no cure currently available. The exact etiology of autoimmune diseases is not completely clear. Biomedical research has revealed that both genetic and environmental factors contribute to the development and progression of these diseases. Nevertheless, genetic and environmental factors alone cannot explain a large proportion of cases, leading to the possibility that the two factors interact in driving disease onset. Understanding how genetic and environmental factor influence host physiology in a manner that leads to the development of autoimmune diseases can reveal the mechanisms by which these diseases manifest, and bring us closer to finding a cure for them. In this chapter, we will review the current research of genetic/environmental interactions that contribute to development of autoimmune diseases, with an emphasis on interactions between the host and the multitudes of microbes that inhabit it, the microbiota.


2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.


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