scholarly journals Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study

Life ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 15
Author(s):  
Mahdi Al-Taher ◽  
Jacqueline van den Bos ◽  
Ivon Terink ◽  
Sander van Kuijk ◽  
Nehalennia van Hanegem ◽  
...  
Keyword(s):  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Subjective Evaluations ◽  
Intraoperative Detection ◽  
Nirf Imaging ◽  
Peritoneal Endometriosis ◽  
The Mean ◽  
Additional Value ◽  
Near Infrared Fluorescence Imaging ◽  
Endometriosis Surgery

Introduction: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy. Materials and methods: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed. Results: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05). Conclusion: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions.

scholarly journals Intra-operative assessment of the vascularisation of a cross section of the meniscus using near-infrared fluorescence imaging

2021 ◽  
Author(s):  
Peter van Schie ◽  
Thies J. N. van der Lelij ◽  
Maxime Gerritsen ◽  
Ruben P. J. Meijer ◽  
Ewoud R. A. van Arkel ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Cross Section ◽  
Near Infrared ◽  
Level Of Evidence ◽  
Camera System ◽  
Near Infrared Fluorescence ◽  
Nirf Imaging ◽  
Total Knee ◽  
Operative Assessment ◽  
Near Infrared Fluorescence Imaging

Abstract Purpose The purpose of this study was to assess whether the vascularisation of the meniscus could be visualised intra-operatively using near-infrared fluorescence (NIRF) imaging with indocyanine green (ICG) in patients undergoing total knee arthroplasty (TKA). Methods The anterior horn (i.e., Cooper classification: zones C and D) of the meniscus that was least affected (i.e., least degenerative) was removed during TKA surgery in ten patients to obtain a cross section of the inside of the meniscus. Thereafter, 10 mg of ICG was injected intravenously, and vascularisation of the cross section of the meniscus was assessed using the Quest spectrum NIRF camera system. We calculated the percentage of patients in whom vascularisation was observed intra-operatively using NIRF imaging compared to immunohistochemistry. Results Meniscal vascularisation using NIRF imaging was observed in six out of eight (75%) patients in whom vascularisation was demonstrated with immunohistochemistry. The median extent of vascularisation was 13% (interquartile range (IQR) 3–28%) using NIRF imaging and 15% (IQR 11–23%) using immunohistochemistry. Conclusion This study shows the potential of NIRF imaging to visualise vascularisation of the meniscus, as vascularisation was observed in six out of eight patients with histologically proven meniscal vascularisation. Level of evidence IV.

scholarly journals Near Infrared Fluorescence Imaging to Assess Breast Flap Perfusion and Prevention of Ischemia: Case Report

2019 ◽  
Vol 103 (9-10) ◽  
pp. 473-476
Author(s):  
Ju Yong Cheong ◽  
David Goltsman ◽  
Sanjay Warrier
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Imaging System ◽  
Skin Flap ◽  
Color Temperature ◽  
Near Infrared Fluorescence ◽  
Clinical Method ◽  
Nirf Imaging ◽  
Near Infrared Fluorescence Imaging ◽  
Flap Perfusion

Introduction: Breast skin flap ischemia and necrosis is a serious consequence of breast reconstruction with reported incidence of 10% to 15%. Current clinical method of assessing breast skin flap perfusion includes combination of skin color, temperature, dermal edge bleeding, and capillary refill. Given the high incidence of ischemia and the presence of certain cohort of patient with greater risk, there is a need for an objective method of assessing the skin flap perfusion. Near infrared fluorescence imaging using indocyanine green is a new technique of assessing skin flap perfusion. We present a first reported case where breast skin flap ischemia was objectively identified intraoperatively by NIRF imaging, and this ischemia was reversed through active intra- and postoperative measures, which was objectively again identified by NIRF imaging. Case presentation: A 36-year-old female patient underwent bilateral nipple sparing mastectomies with immediate reconstruction using tissue expanders. Clinical assessment of the breast skin flap was equivocal. NIRF imaging using SPY imaging system (Novadaq Technologies Inc, Toronto, ON, Canada) showed poor perfusion in the periareolar region. As a result, it was decided to completely deflate the expander, actively warm the skin flap and encourage cutaneous perfusion through use of topical glycerin trinitrate patch. A repeat NIRF imaging 48 hours showed 10-fold increase in perfusion in the skin flap. Conclusion: NIRF imaging is a useful tool in assessing breast skin perfusion and to predict potential ischemia, which can aid in surgeon's management of patient.

scholarly journals Indocyanine Green Near-Infrared Fluorescence Imaging-Guided Laparoscopic Heminephrectomy for Left Ureteral Cancer in Patient with Horseshoe Kidney

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Takao Natsuyama ◽  
Yozo Mitsui ◽  
Masato Uetani ◽  
Shigeyuki Ohta ◽  
Shin-ichi Hisasue
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Imaging System ◽  
Left Kidney ◽  
Horseshoe Kidney ◽  
Near Infrared Fluorescence ◽  
Nirf Imaging ◽  
Novel Approach ◽  
The Right ◽  
Near Infrared Fluorescence Imaging

Laparoscopic surgery for patients with a horseshoe kidney is challenging because of the location, aberrant vasculature, and difficulty with division of the isthmus with adequate hemostasis. We herein report performance of a laparoscopic heminephrectomy for left ureteral cancer in a patient with a horseshoe kidney under guidance from near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG). A 62-year-old male was referred to our hospital for treatment of left ureteral cancer associated with a horseshoe kidney. We performed a laparoscopic left nephroureterectomy and bladder resection in June 2017. During the operation, the NIRF imaging system was used to evaluate the border of the kidney parenchyma isthmus after ligation of the left kidney vasculature supply. Interestingly, the dominant region of the right kidney showed strong ICG fluorescence as compared to the left kidney region. With the assistance of ICG-based NIRF imaging, isthmus division was performed with monopolar scissors and adequate hemostasis was obtained by electrocautery coagulation. This is the first report of use of an ICG-based NIRF imaging system and this novel approach can help to demarcate the left moiety isthmus from right one with more certainty.

In vivo pharmacodynamic evaluation of antidepressants based on flux mitochondrial Cys in living mice via near infrared fluorescence imaging

The Analyst ◽  
2020 ◽  
Vol 145 (18) ◽  
pp. 6119-6124
Author(s):  
Xin Wang ◽  
Jiali Zha ◽  
Wei Zhang ◽  
Wen Zhang ◽  
Bo Tang
Keyword(s):  
Fluorescence Imaging ◽  
Mouse Brain ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Nirf Imaging ◽  
New Strategy ◽  
Near Infrared Fluorescence Imaging

We proposed a new strategy for in vivo evaluation of antidepressants through NIRF imaging for mitochondrial Cys in the mouse brain.

scholarly journals Handheld Near-Infrared Fluorescence Imaging Device Using Modified Action Cameras for Peri-Operative Guidance of Microvascular Flap Surgery

2021 ◽  
Vol 10 (3) ◽  
pp. 410
Author(s):  
Hyunwoo Yang ◽  
Jihong Kim ◽  
Woong Nam ◽  
Hyung Jun Kim ◽  
In-ho Cha ◽  
...  
Keyword(s):  
Near Infrared ◽  
Cost Effective ◽  
Flap Surgery ◽  
Imaging Device ◽  
Near Infrared Fluorescence ◽  
Nirf Imaging ◽  
Microvascular Flap ◽  
The Many ◽  
Near Infrared Fluorescence Imaging ◽  
New Generation

Indocyanine green near-infrared fluorescence (ICG-NIRF) imaging has recently come into use as a novel method in peri-operative microvascular flap assessment. However, a majority of the many commercial devices launched for clinical use lack mobility, portability, and cost-efficiency and are thus unsuitable for intra-oral applications. This study introduces a cost-effective, customized, handheld NIRF device following principles of ICG-NIRF imaging. Moreover, the novel characteristics of our prototype, considered in conjunction with a literature review highlighting the significance of fluorescence devices in microvascular surgery, point to a new generation of devices for use in microvascular flap surgery.

scholarly journals Attempt of Real-Time Near-Infrared Fluorescence Imaging Using Indocyanine Green (ICG) in Radical Resection of Gallbladder Cancer: A Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Yang Yu ◽  
Lin Xiang ◽  
Yuping Bai ◽  
Ewetse Paul Maswikiti ◽  
Baohong Gu ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Real Time ◽  
Near Infrared ◽  
Operative Procedure ◽  
Biliary Tree ◽  
Radical Resection ◽  
Older Woman ◽  
Near Infrared Fluorescence ◽  
Nirf Imaging ◽  
Near Infrared Fluorescence Imaging

Surgery is the mainstay of treatment for resectable gallbladder cancer. Near-infrared fluorescence (NIRF) imaging using ICG is an innovation in laparoscopic surgery, which can provide real-time navigation during the whole operation. In this article, we present a 56-year older woman with gallbladder cancer, in which we evaluated the applicability of NIRF imaging using ICG for tumor and biliary tree visualization during the operative procedure of gallbladder cancer. The tumor and biliary tree were clearly visualized by utilizing a green fluorescence dye. The patient was successfully operated radical resection of gallbladder cancer under fluorescence laparoscope, without any complications. According to this case, the utilization of ICG based NIRF imaging is feasible and beneficial in identifying tumors and the biliary tree during radical resection. It can assist in the achievement of a negative margin and lymphatic clearance around the biliary tree. However, further studies are needed to corroborate the results of this case.

scholarly journals Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1753
Author(s):  
Xiaotian Wu ◽  
Amy Daniel Ulumben ◽  
Steven Long ◽  
Wataru Katagiri ◽  
Moses Q. Wilks ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Near Infrared ◽  
Imaging Systems ◽  
Short Exposure ◽  
Near Infrared Fluorescence ◽  
Nirf Imaging ◽  
Fda Approval ◽  
Diseased Vessel ◽  
The Right ◽  
Near Infrared Fluorescence Imaging

Successful imaging of atherosclerosis, one of the leading global causes of death, is crucial for diagnosis and intervention. Near-infrared fluorescence (NIRF) imaging has been widely adopted along with multimodal/hybrid imaging systems for plaque detection. We evaluate two macrophage-targeting fluorescent tracers for NIRF imaging (TLR4-ZW800-1C and Feraheme-Alexa Fluor 750) in an atherosclerotic murine cohort, where the left carotid artery (LCA) is ligated to cause stenosis, and the right carotid artery (RCA) is used as a control. Imaging performed on dissected tissues revealed that both tracers had high uptake in the diseased vessel compared to the control, which was readily visible even at short exposure times. In addition, ZW800-1C’s renal clearance ability and Feraheme’s FDA approval puts these two tracers in line with other NIRF tracers such as ICG. Continued investigation with these tracers using intravascular NIRF imaging and larger animal models is warranted for clinical translation.

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