Influence of Vanillin Acrylate-Based Resin Composition on Resin Photocuring Kinetics and Antimicrobial Properties of the Resulting Polymers

The investigation of the influence of vanillin acrylate-based resin composition on photocuring kinetics and antimicrobial properties of the resulting polymers was performed in order to find efficient photocurable systems for optical 3D printing of bio-based polymers with tunable rigidity, as well as with antibacterial and antifungal activity. Two vanillin derivatives, vanillin diacrylate and vanillin dimethacrylate, were tested in photocurable systems using phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide as a photoinitiator. The influence of vanillin acrylate monomer, amount of photoinitiator, presence and amount of dithiol, and presence of solvent on photocuring kinetics was investigated by real-time photoreometry. Polymers of different rigidity were obtained by changing the photocurable resin composition. The photocuring kinetics of the selected vanillin acrylate-based resins was comparable with that of commercial petroleum-based acrylate resins for optical 3D printing. Polymers based on both vanillin acrylates showed a significant antibacterial activity against Escherichia coli and Staphylococcus aureus. Vanillin diacrylate-based polymer films also demonstrated an antifungal activity in direct contact with Aspergillus niger and Aspergillus terreus. Vanillin diacrylate-based dual curing systems were selected as the most promising for optical 3D printing of bio-based polymers with antibacterial and antifungal activity.

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Antibacterial and Antifungal Activity of Medicinal Orchids Growing in Nepal

Journal of Nepal Chemical Society ◽

10.3126/jncs.v29i0.9259 ◽

2013 ◽

Vol 29 ◽

pp. 104-109 ◽

Cited By ~ 7

Author(s):

Ramesh Marasini ◽

Susan Joshi

Keyword(s):

Staphylococcus Aureus ◽

Antifungal Activity ◽

Vibrio Cholerae ◽

Chemical Society ◽

Antibacterial Activities ◽

Good Activity ◽

Antibacterial And Antifungal Activity ◽

Zone Of Inhibition ◽

Antibacterial And Antifungal ◽

And Staphylococcus Aureus

Antibacterial activities of different extracts of epiphytic orchids were tested against 5 species of bacteria and antifungal activities were tested against 3 species of fungi. All orchid extracts showed good bacterial Zone of Inhibition (ZOI) against Staphylococcus aureus. The crude extracts of Pholidota imbricata and Coelogyne cristata were shown highest activity against Vibrio cholerae and Staphylococcus aureus respectively. The MIC and MBC value of the extracts of Pholidota imbricata and Coelogyne cristata were found to be 62.5 mg/ml, 31.25 mg/ml and 125 mg/ml, 250 mg/ml against Vibrio cholerae and Staphylococcus aureus respectively. Only Pholidota imbricata and Pholidota articulata extracts were shown fairly good activity but all others extracts were shown very less activity or even failed to show any activity against fungal organisms.DOI: http://dx.doi.org/10.3126/jncs.v29i0.9259Journal of Nepal Chemical Society Vol. 29, 2012 Page: 104-109 Uploaded date: 12/5/2013

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Synthesis and Antimicrobial Properties of Naphthylamine Derivatives Having a Thiazolidinone Moiety

Medicina ◽

10.3390/medicina47060047 ◽

2011 ◽

Vol 47 (6) ◽

pp. 47

Author(s):

Vilma Petrikaitė ◽

Eduardas Tarasevičius ◽

Alvydas Pavilonis

Keyword(s):

Antibacterial Activity ◽

Minimum Inhibitory Concentration ◽

Antifungal Activity ◽

Inhibitory Concentration ◽

Antimicrobial Properties ◽

Microbiological Analysis ◽

Antibacterial And Antifungal Activity ◽

Antibacterial And Antifungal ◽

New Compounds

Objective. The aim of this study was to evaluate the influence of pharmacophores having naphthylamine and nitro groups on the antimicrobial (antibacterial and antifungal) activity of thiazolidinone derivatives. Materials and Methods. The initial 5-substituted-2-methylmercaptothiazolidin-4-ones were subjected to S-demethylation to yield 2-amino-substituted thiazolidinones. 4-Nitro-1-naphthylamine, nitrofuran aldehydes, and nitrobenzene aldehydes were used as pharmacophoric compounds having amino or aldehyde groups. Antimicrobial (antibacterial and antifungal) activity of the new compounds was tested in vitro against bacterial cultures – Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae – and fungal cultures – Candida albicans, Candida glabrata, Candida krusei, Candida kefyr, Candida tropicalis, and Candida parapsilosis. Results. Microbiological analysis showed that all new thiazolidinone derivatives with nitronaphthylamine substituent possessed antibacterial and antifungal properties. New compounds 2a-b showed similar antibacterial activity in vitro against S. aureus and B. subtilis as aminopenicillins. The lowest antibacterial activity of all newly synthesized compounds was against capsule-forming bacteria K. pneumoniae and against gram-negative bacteria E. coli (minimum inhibitory concentration range, 500–1000 μg/mL). Conclusions. The minimum inhibitory concentration of naphthylamine derivatives varied in the range of 0.4–1000 μg/mL, and activity of some newly synthesized compounds was similar to the activity of aminopenicillins and fluconazole, an antifungal preparation. Based on the results, it is possible to separate the perspective group of potential antimicrobial compounds.

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