scholarly journals A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment

Mathematics ◽  
2021 ◽  
Vol 9 (24) ◽  
pp. 3323
Author(s):  
Rami Zakh ◽  
Alexander Churkin ◽  
William Bietsch ◽  
Menachem Lachiany ◽  
Scott J. Cotler ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Hepatitis B Virus ◽  
Simple Model ◽  
Kinetic Model ◽  
Hepatitis Delta Virus ◽  
Chronic Viral Hepatitis ◽  
Severe Form ◽  
Specific Therapy ◽  
B Virus ◽  
Delta Virus

Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.

scholarly journals Analysis of Multiple Liver Explant Pieces Reveals that Levels of Hepatitis Delta Virus RNA Are Independent of Hepatitis B Virus Expression

2021 ◽  
Author(s):  
Kasthuri Prakash ◽  
Simon B. Larsson ◽  
Gustaf E. Rydell ◽  
Johan Ringlander ◽  
Catarina Skoglund ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Hepatitis Delta ◽  
Virus Rna ◽  
B Virus ◽  
Virus Expression ◽  
Delta Virus

Occurrence of Hepatitis Delta Virus Infection in Hepatitis B Virus-Infected Patients with Different Serum Patterns of PreS Gene-Encoded Proteins

Digestion ◽  
1993 ◽  
Vol 54 (1) ◽  
pp. 9-14
Author(s):  
Nicola Napoli ◽  
Giorgio Fiore ◽  
Giacomo Fera ◽  
Angela Modugno ◽  
Gianluigi Giannelli ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Hepatitis Delta ◽  
Hepatitis Delta Virus Infection ◽  
B Virus ◽  
Encoded Proteins ◽  
Delta Virus

scholarly journals A Divergent Hepatitis D-Like Agent in Birds

Viruses ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 720 ◽  
Author(s):  
Michelle Wille ◽  
Hans Netter ◽  
Margaret Littlejohn ◽  
Lilly Yuen ◽  
Mang Shi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Hepatitis B Virus ◽  
Sequence Analysis ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Amino Acid Similarity ◽  
Hepatitis D ◽  
Delta Antigen ◽  
B Virus ◽  
Delta Virus

Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents.

Farnesoid X receptor alpha ligands inhibit hepatitis delta virus replication in vitro independently of their effect on hepatitis B virus

2020 ◽  
Vol 73 ◽  
pp. S834-S835
Author(s):  
Benoît Lacombe ◽  
Julie Lucifora ◽  
Camille Ménard ◽  
Michelet Maud ◽  
Adrien Foca ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Hepatitis Delta Virus ◽  
Farnesoid X Receptor ◽  
Hepatitis Delta ◽  
Receptor Alpha ◽  
B Virus ◽  
Delta Virus

scholarly journals Influence of Hepatitis B Virus (HBV) Genotype on the Clinical Course of Disease in Patients Coinfected with HBV and Hepatitis Delta Virus

2009 ◽  
Vol 199 (11) ◽  
pp. 1608-1611 ◽  
Author(s):  
Dagmar Kiesslich ◽  
Myuki Alfaia Crispim ◽  
Carlos Santos ◽  
Fernando de Lima Ferreira ◽  
Nelson Abrahim Fraiji ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Clinical Course ◽  
Hbv Genotype ◽  
Hepatitis Delta ◽  
Course Of Disease ◽  
B Virus ◽  
Delta Virus
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