scholarly journals Dechdigliotoxins A–C, Three Novel Disulfide-Bridged Gliotoxin Dimers from Deep-Sea Sediment Derived Fungus Dichotomomyces cejpii

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 596 ◽  
Author(s):  
Zhaoming Liu ◽  
Zhen Fan ◽  
Zhanghua Sun ◽  
Hongxin Liu ◽  
Weimin Zhang
Keyword(s):  
Tumor Cell ◽  
Quantum Chemical Calculations ◽  
Cell Lines ◽  
Deep Sea ◽  
Quantum Chemical ◽  
Biosynthetic Pathway ◽  
Spectroscopic Analysis ◽  
Tumor Cell Lines ◽  
Disulfide Linkage ◽  
Deep Sea Sediment

Dechdigliotoxins A–C (1–3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute configurations were unambiguously determined through quantum chemical calculations, as well as DP4+ probability simulations. The proposed biosynthetic pathway suggested 1–3 were generated from unusual L-Phe and D-Ser. All the isolates were evaluated for their cytotoxicity against four tumor cell lines.

20-Nor-isopimarane cycloethers from the deep-sea sediment-derived fungus Aspergillus wentii SD-310

RSC Advances ◽  
2016 ◽  
Vol 6 (79) ◽  
pp. 75981-75987 ◽  
Author(s):  
Xin Li ◽  
Xiao-Ming Li ◽  
Xiao-Dong Li ◽  
Gang-Ming Xu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Deep Sea ◽  
Tumor Cell Lines ◽  
Deep Sea Sediment ◽  
Aspergillus Wentii ◽  
Tetracyclic System

Five new 20-nor-isopimaranes, asperethers A–E (1–5), were isolated from the deep-sea derived fungus Aspergillus wentii SD-310. These compounds possess a unique 6/6/6/5 tetracyclic system and exhibited cytotoxicity against several tumor cell lines.

scholarly journals Cytotoxic Polyketides from a Deep-Sea Sediment Derived Fungus Diaporthe phaseolorum FS431

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3062 ◽  
Author(s):  
Zheng Niu ◽  
Yuchan Chen ◽  
Heng Guo ◽  
Sai-Ni Li ◽  
Hao-Hua Li ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Deep Sea ◽  
Human Tumor ◽  
Electron Capture Detection ◽  
Cytotoxic Activities ◽  
Tumor Cell Lines ◽  
Deep Sea Sediment ◽  
Diaporthe Phaseolorum

Two new chromone-derived polyketides phaseolorins, G and H (1 and 2), and one new anthraquinone derivative, phaseolorin I (3), together with three known compounds (4–6), were isolated from the deep-sea sediment-derived fungus Diaporthe phaseolorum FS431. The structures of the new compounds were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of 1 was established by quantum chemical calculations of electron capture detection (ECD). All the isolated compounds (1–6) were tested for their in vitro cytotoxic activities against four human tumor cell lines, of which compound 4 exhibited significant effect against MCF-7, HepG-2, and A549 tumor cell lines with IC50 values of 2.60, 2.55, and 4.64 µM, respectively.

scholarly journals Paulomycin G, a New Natural Product with Cytotoxic Activity against Tumor Cell Lines Produced by Deep-Sea Sediment Derived Micromonospora matsumotoense M-412 from the Avilés Canyon in the Cantabrian Sea

Marine Drugs ◽  
2017 ◽  
Vol 15 (9) ◽  
pp. 271 ◽  
Author(s):  
Aida Sarmiento-Vizcaíno ◽  
Alfredo Braña ◽  
Ignacio Pérez-Victoria ◽  
Jesús Martín ◽  
Nuria de Pedro ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Natural Product ◽  
Cell Lines ◽  
Deep Sea ◽  
Tumor Cell Lines ◽  
Deep Sea Sediment ◽  
Avilés Canyon

scholarly journals Two New Anthraquinones from the Roots of Prismatomeris connata

2016 ◽  
Vol 11 (4) ◽  
pp. 1934578X1601100
Author(s):  
Chun-Xiang Wang ◽  
Sa-Na Zhao ◽  
Shi-Xiu Feng ◽  
Xiao-Ping Zhang ◽  
Tao Chen
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Spectroscopic Analysis ◽  
Lung Tumor ◽  
Medicinal Herb ◽  
Tumor Cell Lines ◽  
Chinese Medicinal Herb ◽  
Lung Tumor Cell

Two new anthraquinones, 4-hydroxy-1,2,3-trimethoxy-7-hydroxymethylanthracene-9,10-dione (1) and 1,2,3-trimethoxy-7-hydroxymethylanthracene-9,10-dione (2), were isolated from the roots of Prismatomeris connata, a Chinese medicinal herb. Their structures were elucidated by spectroscopic analysis. Compound 1 exhibited cytotoxicity against a panel of H1229, HTB179, A549 and H520 lung tumor cell lines with IC50 values ranging from 12.3 to 20 μM.

scholarly journals Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 448 ◽  
Author(s):  
Xiao Liang ◽  
Zhong-Hui Huang ◽  
Xuan Ma ◽  
Shu-Hua Qi
Keyword(s):  
Antibacterial Activity ◽  
Quantum Chemical Calculations ◽  
Acid Derivative ◽  
Deep Sea ◽  
Quantum Chemical ◽  
Spectroscopic Analysis ◽  
Fungal Strain ◽  
Cytotoxic Activities ◽  
Tetramic Acid ◽  
Cladosporium Sphaerospermum

Seven new unstable tetramic acid derivatives, cladosporiumins I-O (1–7), together with the known analogue cladodionen (8) were isolated from the extract of the deep-sea-derived fungus Cladosporium sphaerospermum EIODSF 008. Their structures were elucidated by spectroscopic analysis, quantum chemical calculations and ECD spectra. Compound 4 was a Mg complex of tetramic acid derivative. In acidic solvent, 4 could change to 1 and 6, and 7 could change to 5. In addition, 1, 5 and 8 existed as two exchangeable isomers, respectively. The structures of cladosporiumins E-H were reassigned as their Na complexes. The antibacterial and cytotoxic activities of 1–8 were also evaluated. However, because of their instability, all of the isolated compounds did not show significant antibacterial activity as the preliminary EtOAc extracts of the fungal strain.

scholarly journals Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2221 ◽  
Author(s):  
Mohamed-Elamir Hegazy ◽  
Ahmed Hamed ◽  
Mahmoud Ibrahim ◽  
Zienab Talat ◽  
Eman Reda ◽  
...  
Keyword(s):  
Solvent Extraction ◽  
Tumor Cell ◽  
Cell Lines ◽  
Proliferative Activity ◽  
Spectroscopic Analysis ◽  
A549 Cells ◽  
Tumor Cell Lines ◽  
Circular Dichorism

Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.

Expression of HIF-1a and VEGF in human pituitary tumors and rodent pituitary tumor cell lines under hypoxia-mimicking condition

2008 ◽  
Vol 116 (09) ◽  
Author(s):  
B Shan ◽  
C Onofri ◽  
M Theodoropoulou ◽  
E Arzt ◽  
GK Stalla ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Pituitary Tumor ◽  
Pituitary Tumors ◽  
Tumor Cell Lines ◽  
Human Pituitary ◽  
Pituitary Tumor Cell

Interaction of Human Tumor Cells with Human Platelets and the Coagulation System

1983 ◽  
Vol 50 (03) ◽  
pp. 726-730 ◽  
Author(s):  
Hamid Al-Mondhiry ◽  
Virginia McGarvey ◽  
Kim Leitzel
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Lines ◽  
Human Tumor ◽  
Human Platelets ◽  
Factor Vii ◽  
Coagulation System ◽  
Breast Adenocarcinoma ◽  
Activate Factor ◽  
Tumor Cell Lines

SummaryThis paper reports studies on the interaction between human platelets, the plasma coagulation system, and two human tumor cell lines grown in tissue culture: Melanoma and breast adenocarcinoma. The interaction was monitored through the use of 125I- labelled fibrinogen, which measures both thrombin activity generated by cell-plasma interaction and fibrin/fibrinogen binding to platelets and tumor cells. Each tumor cell line activates both the platelets and the coagulation system simultaneously resulting in the generation of thrombin or thrombin-like activity. The melanoma cells activate the coagulation system through “the extrinsic pathway” with a tissue factor-like effect on factor VII, but the breast tumor seems to activate factor X directly. Both tumor cell lines activate platelets to “make available” a platelet- derived procoagulant material necessary for the conversion of prothrombin to thrombin. The tumor-derived procoagulant activity and the platelet aggregating potential of cells do not seem to be inter-related, and they are not specific to malignant cells.

Differential Increases in Glutathione S-Transferase Activities in a Range of Multidrug-Resistant Human Tumor Cell Lines

1989 ◽  
Vol 1 (6) ◽  
pp. 359-365 ◽  
Author(s):  
Richard D. H. Whelan ◽  
Louise K. Hosking ◽  
Alan J. Townsend ◽  
Kenneth H. Cowan ◽  
Bridget T. Hill
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Multidrug Resistant ◽  
Tumor Cell Lines ◽  
Glutathione S Transferase ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines
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