Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer

Background and Objectives: Increased osteopontin (OPN) concentrations in the plasma of patients with head and neck squamous cancer (HNSCC) have diagnostic significance, and it can indicate more aggressive biological behavior of cancer. The aim of this study was to determine OPN levels in patients with HNSCC of different primary locations and to assess its prognostic significance in metastasis development. Materials and Methods: This cohort study included 45 patients (41 male and 4 female patients) with HNSCC with different primary localization of head and neck. All patients underwent surgery—neck dissection. All patients were categorized according to the histological findings of the resected material and tumor–node–metastasis (TNM) classification system. After surgery, N categories were determined on the basis of histological features of resected material. Results: The histological findings of our patients showed: N0 in 11 patients, N1 in 8 patients, N2a in 4 patients, N2b in 14 patients and N2c in 8 patients. Plasma OPN values in all study participants ranged from 2.24 to 109.10 ng/mL. OPN levels in plasma of patients with negative nodes compared to the group of patients with positive nodes in the neck differed significantly (16.89 ng/mL to 34.08 ng/mL, respectively; p = 0.03). There were significantly lower OPN plasma levels in the group of subjects with histologically positive one lymph node in the neck (N1) compared to the group of patients with N2b histologically positive findings of resected neck material (10.4 ng/mL to 43.9 ng/mL, respectively; p = 0.02). Conclusions: The results have shown that growing N degrees of positive neck nodes classification were accompanied by growing values of plasma osteopontin. Osteopontin might be important for the development of neck metastases.

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Prognostic significance of tissue proteomic profiling in stage I and II cutaneous malignant melanoma of the head and neck

10.26226/morressier.5a8bfc7ad462b8029238bed6 ◽

2018 ◽

Author(s):

Andro Košec

Keyword(s):

Malignant Melanoma ◽

Head And Neck ◽

Prognostic Significance ◽

Cutaneous Malignant Melanoma ◽

Stage I ◽

Proteomic Profiling

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Faculty Opinions recommendation of p16 expression in cutaneous squamous carcinomas with neck metastases: a potential pitfall in identifying unknown primaries of the head and neck.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717962964.793465021 ◽

2012 ◽

Author(s):

Giulio Cantu ◽

Madia Pompilio ◽

Paolo Formillo

Keyword(s):

Head And Neck ◽

Potential Pitfall ◽

Neck Metastases ◽

P16 Expression

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The Prognostic Significance of Circulating Tumour Cells in Head and Neck and Non-Small Cell Lung Cancer

SSRN Electronic Journal ◽

10.2139/ssrn.3237005 ◽

2018 ◽

Author(s):

Arutha Kulasinghe ◽

Joanna Kapeleris ◽

Rebecca Kimberley ◽

Stephen R Mattarollo ◽

Erik W Thompson ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Head And Neck ◽

Cell Lung Cancer ◽

Prognostic Significance ◽

Small Cell ◽

Tumour Cells ◽

Circulating Tumour Cells ◽

Small Cell Lung

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Transcriptional Expressions of Matrix Metalloproteinase and Their Diagnostic and Prognostic Significance in Head and Neck Squamous Cell Carcinoma

SSRN Electronic Journal ◽

10.2139/ssrn.3736014 ◽

2020 ◽

Author(s):

Pan Ting ◽

Jingrong Cheng ◽

Ying Yin ◽

Jiaqi Wang ◽

Xiaoru Mao ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Matrix Metalloproteinase ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Prognostic Significance ◽

Neck Squamous Cell Carcinoma

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CCTs as new biomarkers for the prognosis of head and neck squamous cancer

Open Medicine ◽

10.1515/med-2020-0114 ◽

2020 ◽

Vol 15 (1) ◽

pp. 672-688

Author(s):

Yanbo Dong ◽

Siyu Lu ◽

Zhenxiao Wang ◽

Liangfa Liu

Keyword(s):

Head And Neck ◽

Survival Data ◽

Enrichment Analysis ◽

Functional Enrichment Analysis ◽

Functional Enrichment ◽

Advanced Tumor Stage ◽

Expression Levels ◽

T Complex ◽

Advanced Tumor ◽

Squamous Cancer

AbstractThe chaperonin-containing T-complex protein 1 (CCT) subunits participate in diverse diseases. However, little is known about their expression and prognostic values in human head and neck squamous cancer (HNSC). This article aims to evaluate the effects of CCT subunits regarding their prognostic values for HNSC. We mined the transcriptional and survival data of CCTs in HNSC patients from online databases. A protein–protein interaction network was constructed and a functional enrichment analysis of target genes was performed. We observed that the mRNA expression levels of CCT1/2/3/4/5/6/7/8 were higher in HNSC tissues than in normal tissues. Survival analysis revealed that the high mRNA transcriptional levels of CCT3/4/5/6/7/8 were associated with a low overall survival. The expression levels of CCT4/7 were correlated with advanced tumor stage. And the overexpression of CCT4 was associated with higher N stage of patients. Validation of CCTs’ differential expression and prognostic values was achieved by the Human Protein Atlas and GEO datasets. Mechanistic exploration of CCT subunits by the functional enrichment analysis suggests that these genes may influence the HNSC prognosis by regulating PI3K-Akt and other pathways. This study implies that CCT3/4/6/7/8 are promising biomarkers for the prognosis of HNSC.

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Inhibitory Control of Adjacent Finger Movements while Performing a Modified Version of the Halstead Finger Tapping Test: Effects of Age, Education and Sex

Journal of the International Neuropsychological Society ◽

10.1017/s1355617720001101 ◽

2020 ◽

pp. 1-12

Author(s):

George P. Prigatano ◽

Sandro Barbosa de Oliveira ◽

Carlos Wellington Passos Goncalves ◽

Sheila Marques Denucci ◽

Roberta Monteiro Pereira ◽

...

Keyword(s):

Inhibitory Control ◽

College Education ◽

Healthy Adults ◽

Finger Tapping ◽

Dominant Hand ◽

Motor Inhibition ◽

Finger Movements ◽

Diagnostic Significance ◽

Finger Tapping Test ◽

Study Participants

Abstract Objective: Selective motor inhibition is known to decline with age. The purpose of this study was to determine the frequency of failures at inhibitory control of adjacent finger movements while performing a repetitive finger tapping task in young, middle-aged and older adults. Potential education and sex effects were also evaluated. Methods: Kinematic recordings of adjacent finger movements were obtained on 107 healthy adults (ages 20–80) while they performed a modified version of the Halstead Finger Tapping Test (HTFF). Study participants were instructed to inhibit all finger movements while tapping with the index finger. Results: Inability to inhibit adjacent finger movements while performing the task was infrequent in young adults (2.9% of individuals between 20 and 39 years of age) but increased with age (23.3% between the ages of 40 and 59; 31.0% between ages 60 and 80). Females and males did not differ in their inability to inhibit adjacent finger movements, but individuals with a college education showed a lower frequency of failure to inhibit adjacent finger movements (10.3%) compared to those with a high school education (28.6%). These findings were statistically significant only for the dominant hand. Conclusion: Selective motor inhibition failures are most common in the dominant hand and occur primarily in older healthy adults while performing the modified version of the HFTT. Monitoring selective motor inhibition failures may have diagnostic significance.

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