scholarly journals Bullous Pemphigoid and Other Pemphigoid Dermatoses

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1061
Author(s):  
Valeryia Pratasava ◽  
Vikram Sahni ◽  
Aishwarya Suresh ◽  
Simo Huang ◽  
Abhirup Are ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Clinical Presentation ◽  
The Elderly ◽  
Mucous Membrane Pemphigoid ◽  
Skin Fragility ◽  
Treatment Refractory ◽  
Diagnostic Work ◽  
Work Up ◽  
Variable Clinical Presentation ◽  
Diagnostic Work Up

The pemphigoid family of dermatoses is characterized by autoimmune subepidermal blistering. The classic paradigm for pemphigoid, and the most common member, is bullous pemphigoid. Its variable clinical presentation, with or without frank bullae, is linked by significant pruritus afflicting the elderly. Mucous membrane pemphigoid is an umbrella term for a group of subepidermal blistering dermatoses that favor the mucosal membranes and can scar. Epidermolysis bullosa acquisita is a chronic blistering disorder characterized by skin fragility, sensitivity to trauma, and its treatment-refractory nature. Clinicians that encounter these pemphigoid disorders may benefit from an overview of their clinical presentation, diagnostic work-up, and therapeutic management, with an emphasis on the most frequently encountered pemphigoid disease, bullous pemphigoid.

scholarly journals Heart failure in the elderly: A geriatric syndrome. Picture of the modern situation

2019 ◽  
Vol 89 (1) ◽  
Author(s):  
Valentina Fagotto ◽  
Alessandro Cavarape ◽  
Alessandro Boccanelli
Keyword(s):  
Heart Failure ◽  
Older Patients ◽  
Clinical Presentation ◽  
The Elderly ◽  
Geriatric Syndrome ◽  
Diagnostic Work ◽  
Patient’S History ◽  
Work Up ◽  
Diagnostic Work Up

Among the older patients’ cohort, the aetiology of heart failure is peculiar and differs in many ways from the younger one, both in its epidemiology, diagnostic work-up and clinical presentation. Focusing on this population, we could assume that heart failure is a real geriatric syndrome, characterized by several features, which coexist with other comorbidities and require specific and targeted cares. It is therefore necessary to examine the global burden of heart failure and the patient’s history rather than the causal cardiomyopathy - frequently more than one in the elderly - facing with the condition, bearing in mind the quality of life even before its duration.

scholarly journals Mitochondrial Depletion Syndromes in Children and Adults

2013 ◽  
Vol 40 (5) ◽  
pp. 635-644 ◽  
Author(s):  
Josef Finsterer ◽  
Uwe Ahting
Keyword(s):  
Early Onset ◽  
Genetic Background ◽  
Clinical Presentation ◽  
Progressive External Ophthalmoplegia ◽  
Adult Onset ◽  
Chain Defects ◽  
Diagnostic Work ◽  
Work Up ◽  
Respiratory Chain Defects ◽  
Diagnostic Work Up

Abstract:To highlight differences between early-onset and adult mitochondrial depletion syndromes (MDS) concerning etiology and genetic background, pathogenesis, phenotype, clinical presentation and their outcome. MDSs most frequently occur in neonates, infants, or juveniles and more rarely in adolescents or adults. Mutated genes phenotypically presenting with adult-onset MDS include POLG1, TK2, TyMP, RRM2B, or PEO1/twinkle. Adult MDS manifest similarly to early-onset MDS, as myopathy, encephalo-myopathy, hepato-cerebral syndrome, or with chronic progressive external ophthalmoplegia (CPEO), fatigue, or only minimal muscular manifestations. Diagnostic work-up or treatment is not at variance from early-onset cases. Histological examination of muscle may be normal but biochemical investigations may reveal multiple respiratory chain defects. The outcome appears to be more favorable in adult than in early-onset forms. Mitochondrial depletion syndromes is not only a condition of neonates, infants, or juveniles but rarely also occurs in adults, presenting with minimal manifestations or manifestations like in the early-onset forms. Outcome of adult-onset MDS appears more favorable than early-onset MDS.

Impact of gender on the clinical presentation and diagnosis of deep-vein thrombosis

2010 ◽  
Vol 103 (04) ◽  
pp. 710-717 ◽  
Author(s):  
Hanno Riess ◽  
Viola Hach-Wunderle ◽  
Horst Gerlach ◽  
Heike Carnarius ◽  
Sonja Eberle ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Clinical Presentation ◽  
Risk Groups ◽  
Pretest Probability ◽  
Probability Score ◽  
Vein Thrombosis ◽  
Diagnostic Work ◽  
Deep Vein ◽  
Work Up ◽  
Diagnostic Work Up

SummaryIt is uncertain whether gender influences the clinical presentation of deep-vein thrombosis (DVT) and the discriminative value of the Wells diagnostic pretest probability score. The aim of the study was to determine whether gender impacts the clinical presentation and diagnosis of DVT. The study analysed a cohort of 4,976 outpatients with clinically suspected DVT of the leg prospectively recruited by 326 vascular medicine physicians in the German ambulatory care sector between October and December 2005. The diagnosis of DVT was based on compression ultrasonography in 96% of patients. Among 4,777 patients who had a diagnostic work-up for DVT there were more women (n=2,998) than men (n=1,779). However, the prevalence of confirmed DVT was 37.0% (658/1779) in men vs. 24.3% (730/2,998) in women (p<0.001). Among patients with confirmed DVT, proximal DVT was more common in men (59.6% vs. 44.5% in women, p<0.001). Swelling of the leg, pitting oedema and dilated superficial veins were more frequently reported by men (p<0.001). The percentage of patients with a high probability Wells clinical pretest score was higher in men than in women (67.0% vs. 57.0%, p<0.001). However, overall, the score equally discriminated risk groups for DVT in both sexes. In conclusion, women were more frequently referred for a diagnostic work-up for DVT than men, but the prevalence of DVT was higher in men and their thrombotic events were more severe. Nevertheless, the Wells clinical pretest probability score correctly identified low- and high-risk groups in both genders.

Diagnosing Suspected Stroke: A Cost-Effectiveness Analysis

1985 ◽  
Vol 1 (1) ◽  
pp. 147-158 ◽  
Author(s):  
Mona Britton ◽  
Egon Jonsson ◽  
Lars-Åke Marké ◽  
Veronica Murray
Keyword(s):  
The Elderly ◽  
Elderly Persons ◽  
Industrialized Countries ◽  
Public Concern ◽  
Effectiveness Analysis ◽  
Suspected Stroke ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Acute cerebrovascular disease (CBVD) has an annual incidence of 100–300 per 100,000 inhabitants in the industrialized countries (1,2). CBVD occurs mainly in the elderly. Acute mortality is around 15%. Disablement and decreased quality of life are common consequences. Institutionalized care will be needed after the acute phase for around one-third of the patients (3). Considering the volume of patients and the growing proportion of elderly persons in most countries, stroke poses a major problem for health care. An effective diagnostic work-up as the base for therapy to improve the situation is, therefore, a matter of great public concern, for humanitarian as well as economic reasons.

Clinical Presentation of Sarcoidosis and Diagnostic Work-Up

2014 ◽  
Vol 35 (03) ◽  
pp. 336-351 ◽  
Author(s):  
Jean-François Bernaudin ◽  
Yurdagul Uzunhan ◽  
Marianne Kambouchner ◽  
Pierre-Yves Brillet ◽  
Michael Soussan ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Weil’s disease in a young homeless man living in Lisbon

2020 ◽  
Vol 13 (6) ◽  
pp. e233543 ◽  
Author(s):  
Torcato Moreira Marques ◽  
Paula Oliveira Nascimento ◽  
André Almeida ◽  
Valentina Tosatto
Keyword(s):  
Clinical Presentation ◽  
Multiorgan Failure ◽  
Febrile Illness ◽  
Organ Support ◽  
Acute Febrile Illness ◽  
Acute Renal Injury ◽  
Worldwide Distribution ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Leptospirosis is a zoonotic disease of worldwide distribution caused by infection with Leptospira genus bacteria, a pathogenic spirochaete. We present the case of a 29-year-old man admitted to our hospital with fever and multiorgan failure. He provided poor information about his symptoms. No recent travel or occupational history was reported and his clinical presentation did not suggest any infectious foci. His relatives later disclosed that he had been homeless for 3 weeks in the context of behavioural changes, obtaining foodstuff from waste containers and water from rain puddles. In the setting of this epidemiology, his presentation of fever, jaundice, acute renal injury and thrombocytopaenia suggested leptospirosis. Prompt empirical antimicrobial coverage was started, alongside organ support therapy. The diagnosis was later confirmed through microscopical and molecular methods. The patient made a full recovery. Leptospirosis should be considered early in the diagnostic work-up of any patient with acute febrile illness with multiorgan system involvement, with the identification of risk factors being essential to treat early in development of the disease.

Thalamic Hemorrhage in the Working Class Population: Clinical Presentation and Evolution, Radiographical Properties, Diagnostic Work-Up, and Prognosis

2013 ◽  
Vol 80 (5) ◽  
pp. 660
Author(s):  
J. De Vlieger ◽  
J. Van Loon ◽  
F. Van Calenbergh ◽  
B. Nuttin ◽  
B. Depreitere ◽  
...  
Keyword(s):  
Working Class ◽  
Clinical Presentation ◽  
Thalamic Hemorrhage ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up
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