scholarly journals Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo

Metabolites ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 38 ◽  
Author(s):  
Muhammad Abdullah ◽  
Joe Kornegay ◽  
Aubree Honcoop ◽  
Traci Parry ◽  
Cynthia Balog-Alvarez ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Muscular Dystrophy ◽  
Golden Retriever ◽  
Proline Metabolism ◽  
Targeted Metabolomics ◽  
Golden Retriever Muscular Dystrophy ◽  
Metabolomics Analysis

Ringo: Discordance between the molecular and clinical manifestation in a Golden Retriever Muscular Dystrophy dog

2010 ◽  
Vol 20 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Eder Zucconi ◽  
Marcos Costa Valadares ◽  
Natássia M. Vieira ◽  
Carlos R. Bueno ◽  
Mariane Secco ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Clinical Manifestation ◽  
Golden Retriever ◽  
Golden Retriever Muscular Dystrophy

RADIOGRAPHIC FEATURES OF GOLDEN RETRIEVER MUSCULAR DYSTROPHY

2006 ◽  
Vol 47 (6) ◽  
pp. 574-580 ◽  
Author(s):  
JASON W. BRUMITT ◽  
STEPHANIE C. ESSMAN ◽  
JOE N. KORNEGAY ◽  
JOHN P. GRAHAM ◽  
WILLIAM J. WEBER ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Golden Retriever ◽  
Radiographic Features ◽  
Golden Retriever Muscular Dystrophy

scholarly journals Expiratory dysfunction in young dogs with golden retriever muscular dystrophy

2020 ◽  
Vol 30 (11) ◽  
pp. 930-937
Author(s):  
Eleanor C. Hawkins ◽  
Amanda K. Bettis ◽  
Joe N. Kornegay
Keyword(s):  
Muscular Dystrophy ◽  
Golden Retriever ◽  
Golden Retriever Muscular Dystrophy

scholarly journals Relevant aspects of golden retriever muscular dystrophy for the study of Duchenne muscular dystrophy in humans

2017 ◽  
Vol 47 (10) ◽  
Author(s):  
Julieta Rodini Engrácia de Moraes ◽  
Lygia Maria Mouri Malvestio ◽  
Isabela Mancini Martins ◽  
Patrícia Regina Erdmann Mosko ◽  
Jair Rodini Engracia Filho ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Phenotypic Expression ◽  
Clinical Signs ◽  
Golden Retriever ◽  
Golden Retriever Muscular Dystrophy ◽  
Cardiac Muscles ◽  
Representative Model ◽  
Progressive Weakness

ABSTRACT: Golden Retriever muscular dystrophy (GRMD) is the most representative model for studying Duchenne muscular dystrophy (DMD) in humans, owing its phenotypic expression. DMD is a recessive disorder linked to the X chromosome in which the loss of dystrophin induces progressive weakness and degeneration of the skeletal and cardiac muscles, which lead to replacement by connective and adipose tissues. Onset of clinical signs occurs between 2 and 5 years of age, and many patients die from heart or respiratory failure. The main studies concerning dystrophic Golden Retrievers (DGR) sought to elucidate the pathophysiology of the disease and its clinical implications to develop therapies and alternative treatments to improve the quality of life and increase longevity of DMD patients. This review presents an overview of relevant contributions of the DGR model for elucidating DMD in humans.

65. Single fiber electromyography in the golden retriever muscular dystrophy model

2012 ◽  
Vol 123 (6) ◽  
pp. e35
Author(s):  
R.K. Bhavaraju-Sanka ◽  
J.N. Kornegay ◽  
J.R. Bogan ◽  
J.L. Dow ◽  
J. Howard
Keyword(s):  
Muscular Dystrophy ◽  
Single Fiber ◽  
Golden Retriever ◽  
Golden Retriever Muscular Dystrophy

The cranial sartorius muscle undergoes true hypertrophy in dogs with golden retriever muscular dystrophy

2003 ◽  
Vol 13 (6) ◽  
pp. 493-500 ◽  
Author(s):  
Joe N Kornegay ◽  
Diane D Cundiff ◽  
Daniel J Bogan ◽  
Janet R Bogan ◽  
Carol S Okamura
Keyword(s):  
Muscular Dystrophy ◽  
Sartorius Muscle ◽  
Golden Retriever ◽  
Golden Retriever Muscular Dystrophy

scholarly journals Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis

2017 ◽  
Vol 174 (24) ◽  
pp. 4797-4811 ◽  
Author(s):  
Brian C Jensen ◽  
Traci L Parry ◽  
Wei Huang ◽  
Ju Youn Beak ◽  
Amro Ilaiwy ◽  
...  
Keyword(s):  
Heart Muscle ◽  
Kinase Inhibitor ◽  
Targeted Metabolomics ◽  
Metabolomics Analysis

Fibrogenic cytokines and extent of fibrosis in muscle of dogs with X-linked golden retriever muscular dystrophy

2002 ◽  
Vol 12 (9) ◽  
pp. 828-835 ◽  
Author(s):  
L PASSERINI ◽  
P BERNASCONI ◽  
F BAGGI ◽  
P CONFALONIERI ◽  
F COZZI ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Golden Retriever ◽  
Golden Retriever Muscular Dystrophy
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