Clinical Characteristics Associated with the Development of Cystoid Macular Edema in Patients with Cytomegalovirus Retinitis

We evaluated the incidence and characteristics of eyes with cytomegalovirus (CMV) retinitis according to the occurrence of cystoid macular edema (CME) and identified the risk factors of its occurrence. Patients diagnosed with CMV retinitis and examined using optical coherence tomography were classified according to the development of CME. The CME group was further divided according to the presence of active retinitis at the time of CME development. The demographics, serologic findings, ophthalmic presentations, ocular treatments, and visual prognosis were compared. CME was identified in 25 eyes (17 eyes with active retinitis and 8 eyes with inactive retinitis) out of the 67 eyes with CMV retinitis. Visual acuity was worse in the CME group than in the non-CME group. The CME group had longer CMV viremia duration, zone 1 involvement, and larger extent of CMV retinitis. While CME with concurrent active retinitis developed in eyes with direct foveal involvement of retinitis in the acute phase and required more ganciclovir injections after CME development, CME without active retinitis developed in eyes with larger extents of involvement and more intravitreal ganciclovir injections before CME development. Zone 1 involvement and longer CMV viremia duration were independently associated with the occurrence of CME. CME, which caused visual deterioration, developed in considerable patients with CMV retinitis and had different characteristics according to the presence of active retinitis.

Download Full-text

Cystoid Macular Edema Secondary to Paclitaxel Therapy

Latin American Journal of Ophthalmology ◽

10.25259/lajo-2-2018 ◽

2019 ◽

Vol 2 ◽

pp. 1 ◽

Cited By ~ 3

Author(s):

Anibal Martin Folgar ◽

Jorge Oscar Zarate

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Fluorescein Angiography ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Metastatic Breast ◽

Breast Adenocarcinoma ◽

Optical Coherence ◽

Ophthalmoscopic Examination

We present a 57-year-old referred reduced visual acuity who was in treatment with paclitaxel for developing metastatic breast adenocarcinoma. Ophthalmoscopic examination, optical coherence tomography, and autofluorescence show the cystoid macular edema, but fluorescein angiography is normal, without leakage of dye in the late times. The patient responds well 8 weeks after stopping antineoplastic. Paclitaxel can cause cystoid macular edema and lifting a recovery both anatomical and functional of the macula.

Download Full-text

Incidence of clinical and subclinical macular edema in patients submitted to phacoemulsification in a university health service

ABCS Health Sciences ◽

10.7322/abcshs.2020s03.1850 ◽

2020 ◽

Vol 45 (Suppl.3) ◽

pp. e020103

Author(s):

Luciana de Almeida ◽

Glaucia Luciano da Veiga ◽

Fernando Martins de Oliveira ◽

Fernando Luiz Affonso Fonseca ◽

Vagner Loduca Lima ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Health Service ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Diagnostic Method ◽

Prostaglandin Analogue ◽

Multicenter Studies ◽

Clinically Significant ◽

Low Incidence

Introduction: The incidence of cystoid macular edema (CME) after cataract surgery varies substantially and depending on the diagnostic method used. In addition, other factors that influence the incidence of CME are the technique of surgery and the associated comorbidities. Objective: The aim of the present study was to evaluate the incidence of EMC after uncomplicated phacoemulsification surgery, using the spectral domain optical coherence tomography (OCT). Methods: The incidence of sub-clinical and clinical CME was evaluated in 14 patients who underwent uncomplicated phacoemulsification surgery, using OCT before the surgical procedure and after seven and 28 days after it. The volunteers could not use a prostaglandin analogue or present any retinopathy that compromised visual acuity. Results: The incidence of clinically significant CME was 6.4%, however retinal thickening by OCT was observed in all patients in the fourth postoperative week. Regarding gender and laterality, the percentages were similar. Conclusion: In this study, we obtained a low incidence of EMC in patients assisted at this center, corroborating multicenter studies.

Download Full-text

Visual Outcome in Ocular Sarcoidosis: Retrospective Evaluation of Risk Factors

European Journal of Ophthalmology ◽

10.5301/ejo.2011.6417 ◽

2011 ◽

Vol 21 (6) ◽

pp. 802-810 ◽

Cited By ~ 17

Author(s):

Elisabetta Miserocchi ◽

Giulio Modorati ◽

Federico Di Matteo ◽

Laura Galli ◽

Paolo Rama ◽

...

Keyword(s):

Risk Factors ◽

Visual Acuity ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Multivariable Analysis ◽

Visual Outcome ◽

Ocular Sarcoidosis ◽

Poor Visual Outcome ◽

Posterior Synechia

Purpose. To analyze risk factors associated with poor visual outcome in patients with ocular sarcoidosis. Methods. In this retrospective study, charts of 44 patients with uveitis and biopsy-proven sarcoidosis were reviewed. Ocular parameters evaluated were as follows: location, type of uveitis, visual acuity, presence of posterior synechia, iris nodules, vitritis, snowballs, chorioretinal lesions, retinal vasculitis, papillitis, macular edema, cataract, and glaucoma. Final visual acuity of the worst-seeing eye at last follow-up was the outcome considered in univariable and multivariable analyses. Visual acuity of the worst-seeing eye was stratified into 2 categories according to the threshold 20/50 (≤20/50 and >20/50). Results. A total of 44 patients with bilateral uveitis were studied. The majority of patients presented with panuveitis (52%), granulomatous type (61%), posterior synechia (62%). The most frequent vision-threatening complications were cystoid macular edema (56%) and cataract (56%). The median best-corrected visual acuity in the worst-seeing eye at presentation and at end of follow-up was respectively 0.4 (interquartile range [IQR] 0.26–0.80) and 0.63 (IQR 0.36–1.00). At univariable analysis, the presence of iris nodules (p=0.049), cystoid macular edema (p=0.007), and cataract (p=0.007) were clinically significant conditions for a visual outcome of 20/50 or worse in the worst-seeing eye. In multivariable analysis, cystoid macular edema (p=0.034) was the only statistically significant predictor associated with unfavorable visual outcome. Conclusions. In this study, we attempted to find risk factors related to poor visual outcome in patients with ocular sarcoidosis. The results suggest that only the presence of cystoid macular edema was significantly associated with worst visual outcome.

Download Full-text

Optical coherence tomography in diabetic macular edema: patterns and related risk factors

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v5i2.8727 ◽

2013 ◽

Vol 5 (2) ◽

pp. 190-194 ◽

Cited By ~ 4

Author(s):

Mohammadreza Ahmadpour-Baghdadabad ◽

Masoudreza Manaviat ◽

Ahmad Shojaoddiny-Ardekani

Keyword(s):

Risk Factors ◽

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Vision Loss ◽

Cross Sectional Study ◽

Optical Coherence ◽

Foveal Thickness ◽

Cross Sectional

Introduction: Diabetic Macular Edema (DME) is an important cause of vision loss in diabetic retinopathy. Optical Coherence Tomography (OCT) is a non-invasive modality that produces high-resolution images of retinal layers. Objective: To evaluate the prevalence of DME patterns and their association with risk factors and visual acuity. Materials and Methods: In this cross-sectional study, type 2 diabetics with macular edema referred to our center during a ten-month period underwent OCT. Patients with macular edema due to causes other than diabetes and with OCT images of improper quality were excluded from the study. Four distinct patterns were found in the OCT images. A questionnaire including age, sex, duration of diabetes, serum TG and cholesterol, HbA1c, BMI and visual acuity, as well as the findings of OCT images were filled for the subjects. Results: Eighty-six eyes from 46 patients were evaluated. The most and the least common patterns were sponge-like retinal swelling (SLRS) and posterior hyaloidal traction (PHT) found in 64.0% and 5.8% of the subjects, respectively. A sub-retinal fluid pattern was more common in males (p=0.011) and in patients with serum TG > 200mg/dl (p=0.037). There were significant associations between central foveal (r=0.45, p<0.001), nasal (r=0.35, p=0.001) and temporal (r=0.32, p=0.003) thicknesses with visual acuity. Moreover, the highest thickness (462.4±119.2μm) and also the worst visual acuity (1.0±0.5logMAR) pertained to the cystoid macular edema (CME) pattern. Conclusion: Our study showed that the most common OCT pattern of DME is the sponge-like retinal swelling, while posterior hyaloidal traction has the lowest prevalence. A higher foveal thickness and a lower visual acuity are seen in the CME pattern. Nepal J Ophthalmol 2013; 5(10): 190-194 DOI: http://dx.doi.org/10.3126/nepjoph.v5i2.8727

Download Full-text

Taxane Induced Cystoid Macular Edema: Case Report and Integrated Pathogenic Theory

Current Drug Safety ◽

10.2174/1574886313666180828163016 ◽

2019 ◽

Vol 14 (1) ◽

pp. 43-47 ◽

Cited By ~ 6

Author(s):

M. Kanakis ◽

I. Georgalas ◽

T. Makatsoris ◽

N. Pharmakakis

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Fluorescein Angiography ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Additional Treatment ◽

Published Data ◽

Optical Coherence

Purpose: To report a case of a 73-year-old man who presented with decreased visual acuity due to bilateral macular edema after paclitaxel administration for prostate cancer. Methods: The ophthalmic evaluation consisted of medical and ocular history, Best Corrected Visual Acuity, slit-lamp biomicroscopy and Spectral-domain optical coherence tomography / Fluorescein Angiography. Results: Optical Coherence Tomography and Fluorescein Angiography revealed silent cystoid macular edema. After consulting with the oncologist, the cessation of paclitaxel therapy was decided. The patient presented a gradual but steady resumption of the retinal edema, with complete restoration of normal retinal morphology and function within two months. The pathogenesis of the silent Cystoid Macular Edema (CME) is still unclear. Based on our case and a critical review of the previous observations and published data, we propose that the underlying cause of Taxane induced CME is the functional failure of Aquaporin mediated water transport at the level of retinal Intermediate and Deep capillary plexuses, and at lesser extent at the level of the Retinal Pigment Epithelium. Conclusion: Taxane induced silent CME should be attributed to the action of Taxanes on the microtubule guided aquaporin vesicles transport to the cell membrane. In our case of Taxane induced silent CME, withdrawal of the taxane was enough for complete recovery, and no additional treatment was needed.

Download Full-text

Cystoid macular edema after phacoemulsification: risk factors and effect on visual acuity

Canadian Journal of Ophthalmology ◽

10.3129/i06-062 ◽

2006 ◽

Vol 41 (6) ◽

pp. 699-703 ◽

Cited By ~ 51

Author(s):

Gokhan Gulkilik ◽

Selim Kocabora ◽

Muhittin Taskapili ◽

Gunay Engin

Keyword(s):

Risk Factors ◽

Visual Acuity ◽

Macular Edema ◽

Cystoid Macular Edema

Download Full-text

Risk Factors for Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty

Cornea ◽

10.1097/ico.0000000000001950 ◽

2019 ◽

Vol 38 (7) ◽

pp. 820-824 ◽

Cited By ~ 7

Author(s):

Satoru Inoda ◽

Takahiko Hayashi ◽

Hidenori Takahashi ◽

Itaru Oyakawa ◽

Hideaki Yokogawa ◽

...

Keyword(s):

Risk Factors ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Endothelial Keratoplasty ◽

Descemet Membrane Endothelial Keratoplasty ◽

Descemet Membrane

Download Full-text

Foveal Exudative Macroaneurysm Treated with Intravitreal Ranibizumab

Case Reports in Ophthalmology ◽

10.1159/000431353 ◽

2015 ◽

Vol 6 (2) ◽

pp. 170-175 ◽

Cited By ~ 6

Author(s):

Carlos Menezes ◽

Rui Carvalho ◽

Carla Teixeira ◽

José Alberto Lemos ◽

Rita Gonçalves ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Morphological Data ◽

Foveal Avascular Zone ◽

Optical Coherence ◽

Intravitreal Ranibizumab ◽

Corrected Visual Acuity ◽

Retinal Macroaneurysm ◽

Best Corrected Visual Acuity

Purpose: We report a case of a foveal macroaneurysm with long-standing macular edema in a rare location, successfully treated with intravitreal ranibizumab. Methods: We report the case of a 52-year-old man with left eye long-term visual loss due to macular edema caused by a retinal macroaneurysm, localized about 400 μm from the center of the fovea, and its response to 6 monthly ranibizumab intravitreal injections. His best-corrected visual acuity and morphological data evaluated by optical coherence tomography and fluorescein angiography are presented. Results: His best-corrected visual acuity improved from 1/10 to 3/10 after the 3rd injection, and from 1/10 to 4/10 after the 6th one. The central retinal thickness was evaluated by optical coherence tomography and improved from 310 to 233 μm, with the resolution of both the associated serous detachments and the cystoid macular edema; an almost complete reabsorption of the hard exudates at the end of the treatment was also observed. The macroaneurysm lumen almost obliterated after the 3rd injection and completely collapsed at the end of treatment. Conclusions: Intravitreal ranibizumab may be effective in the treatment of long-standing macular edema associated with foveal macroaneurysms. To the best of our knowledge, this is the first report of a retinal macroaneurysm located so close to the foveal avascular zone.

Download Full-text