Incidence of clinical and subclinical macular edema in patients submitted to phacoemulsification in a university health service

Introduction: The incidence of cystoid macular edema (CME) after cataract surgery varies substantially and depending on the diagnostic method used. In addition, other factors that influence the incidence of CME are the technique of surgery and the associated comorbidities. Objective: The aim of the present study was to evaluate the incidence of EMC after uncomplicated phacoemulsification surgery, using the spectral domain optical coherence tomography (OCT). Methods: The incidence of sub-clinical and clinical CME was evaluated in 14 patients who underwent uncomplicated phacoemulsification surgery, using OCT before the surgical procedure and after seven and 28 days after it. The volunteers could not use a prostaglandin analogue or present any retinopathy that compromised visual acuity. Results: The incidence of clinically significant CME was 6.4%, however retinal thickening by OCT was observed in all patients in the fourth postoperative week. Regarding gender and laterality, the percentages were similar. Conclusion: In this study, we obtained a low incidence of EMC in patients assisted at this center, corroborating multicenter studies.

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Cystoid Macular Edema Secondary to Paclitaxel Therapy

Latin American Journal of Ophthalmology ◽

10.25259/lajo-2-2018 ◽

2019 ◽

Vol 2 ◽

pp. 1 ◽

Cited By ~ 3

Author(s):

Anibal Martin Folgar ◽

Jorge Oscar Zarate

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Fluorescein Angiography ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Metastatic Breast ◽

Breast Adenocarcinoma ◽

Optical Coherence ◽

Ophthalmoscopic Examination

We present a 57-year-old referred reduced visual acuity who was in treatment with paclitaxel for developing metastatic breast adenocarcinoma. Ophthalmoscopic examination, optical coherence tomography, and autofluorescence show the cystoid macular edema, but fluorescein angiography is normal, without leakage of dye in the late times. The patient responds well 8 weeks after stopping antineoplastic. Paclitaxel can cause cystoid macular edema and lifting a recovery both anatomical and functional of the macula.

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CENTRAL RETINAL THICKNESS MEASURED WITH HIGH DEFINITION-OPTICAL COHERENCE TOMOGRAPHY SHOWS A WEAK CORRELATION WITH VISUAL ACUITY IN EYES WITH CLINICALLY SIGNIFICANT MACULAR EDEMA

Evidence-Based Ophthalmology ◽

10.1097/ieb.0b013e3182126a4a ◽

2011 ◽

Vol 12 (2) ◽

pp. 98-99

Author(s):

Talal Alabduljalil ◽

Michael H. Brent

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Retinal Thickness ◽

Central Retinal Thickness ◽

Optical Coherence ◽

Weak Correlation ◽

High Definition ◽

Clinically Significant Macular Edema ◽

Clinically Significant

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Clinical Course of Pseudophakic Cystoid Macular Edema Treated with Nepafenac

Journal of Clinical Medicine ◽

10.3390/jcm9093034 ◽

2020 ◽

Vol 9 (9) ◽

pp. 3034

Author(s):

Alexander Aaronson ◽

Asaf Achiron ◽

Raimo Tuuminen

Keyword(s):

Visual Acuity ◽

Cataract Surgery ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Randomized Clinical Trials ◽

Clinical Course ◽

Total Incidence ◽

Corrected Distance Visual Acuity ◽

Anti Inflammatory ◽

Clinically Significant

Background: To evaluate the clinical course of pseudophakic cystoid macular edema (PCME) treated with topical non-steroidal anti-inflammatory drugs (NSAIDs). Methods: An analysis of the clinical course of PCME consisting of 536 eyes of 536 patients from five consecutive randomized clinical trials aimed at the optimization of anti-inflammatory medication in patients undergoing routine cataract surgery. PCME was classified as (i) grade 0a; no macular thickening, (ii) grade 0b; macular thickening (central subfield macular thickness (CSMT) increase of at least 10%) without signs of macular edema, (iii) grade I; subclinical PCME, (iv) grade II; acute PCME, (v) grade III; long-standing PCME. Eyes with PCME classification from grade I onwards were treated with nepafenac 1 mg/mL t.i.d. for two months. Results: CSMT increase of at least 10% at any postoperative timepoint with cystoid changes—a criterion for PCME—was found in 19 of 536 eyes (total incidence 3.5%). Of these 19 eyes, 13 eyes (total incidence 2.4%) had clinically significant PCME. PCME was considered clinically significant when both of the following visual acuity criteria were fulfilled. At any timepoint after the cataract surgery both the corrected distance visual acuity (CDVA) gain was less than 0.4 decimals from that of preoperative CDVA, and the absolute CDVA level remained below 0.8 decimals. Only one of the 19 eyes with criteria for PCME (total incidence 0.2%, incidence of PCME eyes 5.3%) showed no macular edema resolution within 2 months after topical nepafenac administration. Conclusions: PCME in most cases is self-limiting using topical nepafenac without any further need for intravitreal treatment.

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Taxane Induced Cystoid Macular Edema: Case Report and Integrated Pathogenic Theory

Current Drug Safety ◽

10.2174/1574886313666180828163016 ◽

2019 ◽

Vol 14 (1) ◽

pp. 43-47 ◽

Cited By ~ 6

Author(s):

M. Kanakis ◽

I. Georgalas ◽

T. Makatsoris ◽

N. Pharmakakis

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Fluorescein Angiography ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Additional Treatment ◽

Published Data ◽

Optical Coherence

Purpose: To report a case of a 73-year-old man who presented with decreased visual acuity due to bilateral macular edema after paclitaxel administration for prostate cancer. Methods: The ophthalmic evaluation consisted of medical and ocular history, Best Corrected Visual Acuity, slit-lamp biomicroscopy and Spectral-domain optical coherence tomography / Fluorescein Angiography. Results: Optical Coherence Tomography and Fluorescein Angiography revealed silent cystoid macular edema. After consulting with the oncologist, the cessation of paclitaxel therapy was decided. The patient presented a gradual but steady resumption of the retinal edema, with complete restoration of normal retinal morphology and function within two months. The pathogenesis of the silent Cystoid Macular Edema (CME) is still unclear. Based on our case and a critical review of the previous observations and published data, we propose that the underlying cause of Taxane induced CME is the functional failure of Aquaporin mediated water transport at the level of retinal Intermediate and Deep capillary plexuses, and at lesser extent at the level of the Retinal Pigment Epithelium. Conclusion: Taxane induced silent CME should be attributed to the action of Taxanes on the microtubule guided aquaporin vesicles transport to the cell membrane. In our case of Taxane induced silent CME, withdrawal of the taxane was enough for complete recovery, and no additional treatment was needed.

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Clinical Characteristics Associated with the Development of Cystoid Macular Edema in Patients with Cytomegalovirus Retinitis

Microorganisms ◽

10.3390/microorganisms9061114 ◽

2021 ◽

Vol 9 (6) ◽

pp. 1114

Author(s):

Hye-Ji Kwon ◽

Gisung Son ◽

Joo-Yong Lee ◽

June-Gone Kim ◽

Yoon-Jeon Kim

Keyword(s):

Risk Factors ◽

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Acute Phase ◽

Cystoid Macular Edema ◽

Clinical Characteristics ◽

Development Zone ◽

Cmv Retinitis ◽

Different Characteristics

We evaluated the incidence and characteristics of eyes with cytomegalovirus (CMV) retinitis according to the occurrence of cystoid macular edema (CME) and identified the risk factors of its occurrence. Patients diagnosed with CMV retinitis and examined using optical coherence tomography were classified according to the development of CME. The CME group was further divided according to the presence of active retinitis at the time of CME development. The demographics, serologic findings, ophthalmic presentations, ocular treatments, and visual prognosis were compared. CME was identified in 25 eyes (17 eyes with active retinitis and 8 eyes with inactive retinitis) out of the 67 eyes with CMV retinitis. Visual acuity was worse in the CME group than in the non-CME group. The CME group had longer CMV viremia duration, zone 1 involvement, and larger extent of CMV retinitis. While CME with concurrent active retinitis developed in eyes with direct foveal involvement of retinitis in the acute phase and required more ganciclovir injections after CME development, CME without active retinitis developed in eyes with larger extents of involvement and more intravitreal ganciclovir injections before CME development. Zone 1 involvement and longer CMV viremia duration were independently associated with the occurrence of CME. CME, which caused visual deterioration, developed in considerable patients with CMV retinitis and had different characteristics according to the presence of active retinitis.

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Foveal Exudative Macroaneurysm Treated with Intravitreal Ranibizumab

Case Reports in Ophthalmology ◽

10.1159/000431353 ◽

2015 ◽

Vol 6 (2) ◽

pp. 170-175 ◽

Cited By ~ 6

Author(s):

Carlos Menezes ◽

Rui Carvalho ◽

Carla Teixeira ◽

José Alberto Lemos ◽

Rita Gonçalves ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Morphological Data ◽

Foveal Avascular Zone ◽

Optical Coherence ◽

Intravitreal Ranibizumab ◽

Corrected Visual Acuity ◽

Retinal Macroaneurysm ◽

Best Corrected Visual Acuity

Purpose: We report a case of a foveal macroaneurysm with long-standing macular edema in a rare location, successfully treated with intravitreal ranibizumab. Methods: We report the case of a 52-year-old man with left eye long-term visual loss due to macular edema caused by a retinal macroaneurysm, localized about 400 μm from the center of the fovea, and its response to 6 monthly ranibizumab intravitreal injections. His best-corrected visual acuity and morphological data evaluated by optical coherence tomography and fluorescein angiography are presented. Results: His best-corrected visual acuity improved from 1/10 to 3/10 after the 3rd injection, and from 1/10 to 4/10 after the 6th one. The central retinal thickness was evaluated by optical coherence tomography and improved from 310 to 233 μm, with the resolution of both the associated serous detachments and the cystoid macular edema; an almost complete reabsorption of the hard exudates at the end of the treatment was also observed. The macroaneurysm lumen almost obliterated after the 3rd injection and completely collapsed at the end of treatment. Conclusions: Intravitreal ranibizumab may be effective in the treatment of long-standing macular edema associated with foveal macroaneurysms. To the best of our knowledge, this is the first report of a retinal macroaneurysm located so close to the foveal avascular zone.

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