:
The current review discusses the different synthetic pathways for one of the most important and interesting
heterocyclic ring systems 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action at several
receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers.
Moreover, it has been exploited for the treatment of a variety of cardiovascular diseases due to its potential antihypertensive,
anti-angina, vasodilator, and cardiac depressant activities. Furthermore, it also shows antibacterial, anticancer, antileishmanial, anticoagulant, anticonvulsant, anti-tubercular, antioxidant, antiulcer, and neuroprotective properties. Several
reports have demonstrated dihydropyridine derivatives as a potentiator of cystic fibrosis transmembrane conductance
regulator protein, potent antimalarial agent and HIV-1 protease inhibitor. Herein, we have briefly reviewed different novel
chemistry and synthesis of 1,4-dihydropyridine.
Photochemistry of 1,4-Dihydropyridine Derivatives: Diradical Formation, Delocalization and Trapping as a Route to Novel Tricyclic and Tetracyclic Nitrogen Heterocyclic Ring Systems