scholarly journals Pseudolaric Acid B Induces Growth Inhibition and Caspase-Dependent Apoptosis on Head and Neck Cancer Cell lines through Death Receptor 5

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3715
Author(s):  
Su-Jung Choi ◽  
Chi-Hyun Ahn ◽  
In-Hyoung Yang ◽  
Bohwan Jin ◽  
Won Woo Lee ◽  
...  

Pseudolaric Acid B (PAB), diterpenoid isolated from the root bark of Pseudolarix kaempferi Gordon tree (Pinaceae), exhibits an anti-proliferative and apoptotic activity in various cancer cell lines but to date, the effects of PAB on head and neck cancer (HNC) cell lines remain to be elucidated. In this study, we showed that PAB significantly inhibited the viability and caspase-dependent apoptosis in HN22 cell line. PAB-induced apoptosis is through inducing death receptor 5 (DR5) together with the increase in the expression of cleaved caspase-8. It also inhibited the proliferations and induced apoptosis through DR5 in other three HNC cell lines (HSC3, Ca9.22, and HSC4). Extending our in vitro findings, we found that ethanol extract of Pseudolarix kaempferi (2.5 mg/kg/day) reduced tumor growth in a xenograft model bearing HN22 cell line without any change in body weight. DR5 were also found to be increased in tumors tissue of PAB-treated mice without any apparent histopathological changes in liver or kidney tissues. Taken together, PAB may be a potential lead compound for chemotherapeutic agents against head and neck cancer.

ORL ◽  
2008 ◽  
Vol 70 (4) ◽  
pp. 257-263 ◽  
Author(s):  
Ming Zhao ◽  
Wojciech K. Mydlarz ◽  
Shaoyu Zhou ◽  
Joseph Califano

2017 ◽  
Vol 17 (4) ◽  
pp. 608-614 ◽  
Author(s):  
Sahar Yaghmaei ◽  
Parichehr Ghalayani ◽  
Siamak Salami ◽  
Farahnaz Nourmohammadian ◽  
Soheila Koohestanimobarhan ◽  
...  

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Katie Twigger ◽  
Victoria Roulstone ◽  
Joan Kyula ◽  
Eleni M Karapanagiotou ◽  
Konstantinos N Syrigos ◽  
...  

2007 ◽  
Vol 137 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Kirk P. Withrow ◽  
John P. Gleysteen ◽  
Ahmad Safavy ◽  
Joni Skipper ◽  
Renee A. Desmond ◽  
...  

2019 ◽  
Vol 64 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Dong-Hoon Won ◽  
Shin Hye Chung ◽  
Ji-Ae Shin ◽  
Kyoung-Ok Hong ◽  
In-Hyoung Yang ◽  
...  

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