Chemical Composition and Cytotoxic Activity of the Fractionated Trunk Bark Essential Oil from Tetraclinis articulata (Vahl) Mast. Growing in Tunisia

The aim of the present research was to determine the chemical composition and the cytotoxic effects of Tetraclinis articulata trunk bark essential oil (HEE) obtained by steam distillation and five fractions obtained by normal phase silica chromatographic separation. Chemical analysis allowed the identification of 54 known compounds. Relatively high amounts of oxygenated sesquiterpenes (44.4–70.2%) were detected, mainly consisting of caryophyllene oxide (13.1–26.6%), carotol (9.2–21.2%),14-hydroxy-9-epi-(E)-caryophyllene (3.2–15.5%) and humulene epoxide II (2.6–7.2%). The cytotoxic activity against human mammary carcinoma cell lines (MDA-MB-231) and colorectal carcinoma cell lines (SW620) of the essential oil and its fractions were assessed. All the samples displayed moderate to weak activity compared to 5-fluorouracil. The colorectal carcinoma cell line was relatively more sensitive to the essential oil and its fractions compared to the breast cancer cell line, showing IC50 values from 25.7 to 96.5 μg/mL. In addition, the essential oil and its fraction E.2 revealed a cytotoxic activity against colorectal carcinoma cell line, with IC50 values lower than 30 μg/mL. This is the first report on the chemical composition and cytotoxic activity of the trunk bark essential oil of T. articulata.

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Cytotoxic Activity of Catharanthus roseus (Apocynaceae) Crude Extracts and Pure Compounds Against Human Colorectal Carcinoma Cell Line

International Journal of Pharmacology ◽

10.3923/ijp.2010.43.47 ◽

2009 ◽

Vol 6 (1) ◽

pp. 43-47 ◽

Cited By ~ 16

Author(s):

M.J. Siddiqui ◽

Z. Ismail ◽

A.F.A. Aisha ◽

A.M.S. Abdul Maji

Keyword(s):

Colorectal Carcinoma ◽

Cytotoxic Activity ◽

Cell Line ◽

Catharanthus Roseus ◽

Carcinoma Cell ◽

Carcinoma Cell Line ◽

Colorectal Carcinoma Cell Line ◽

Human Colorectal Carcinoma Cell ◽

Pure Compounds ◽

Human Colorectal Carcinoma

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Diazenyl schiff bases: Synthesis, spectral analysis, antimicrobial studies and cytotoxic activity on human colorectal carcinoma cell line (HCT-116)

Arabian Journal of Chemistry ◽

10.1016/j.arabjc.2017.05.004 ◽

2020 ◽

Vol 13 (1) ◽

pp. 377-392 ◽

Cited By ~ 12

Author(s):

Harmeet Kaur ◽

Siong Meng Lim ◽

Kalavathy Ramasamy ◽

Mani Vasudevan ◽

Syed Adnan Ali Shah ◽

...

Keyword(s):

Spectral Analysis ◽

Colorectal Carcinoma ◽

Cytotoxic Activity ◽

Cell Line ◽

Carcinoma Cell ◽

Colorectal Carcinoma Cell Line ◽

Antimicrobial Studies ◽

Human Colorectal Carcinoma Cell ◽

Hct 116 ◽

Human Colorectal Carcinoma

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Synthesis of New Pt(II) Complex Bearing Organoselenium Ligands and Evaluation of Cytotoxic Activity of Some Structurally Related Pd(II) Complexes

Macedonian Journal of Chemistry and Chemical Engineering ◽

10.20450/mjcce.2020.1905 ◽

2020 ◽

Vol 39 (1) ◽

pp. 59

Author(s):

Ninko Radenković ◽

Marina Kostić ◽

Nataša Đorđević ◽

Zana Doličanin ◽

Tanja Soldatović ◽

...

Keyword(s):

Colorectal Carcinoma ◽

Cytotoxic Activity ◽

Cell Line ◽

Mtt Assay ◽

Carcinoma Cell ◽

In Vitro Study ◽

Colorectal Carcinoma Cell Line ◽

Hct 116 ◽

Healthy Lung

Herein we report the synthesis of new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplatinum(II) complex Pt1. Newly synthetized complex, together with two, structurally related trans-Pd(II) complexes (trans-bis(2-(phenylselenylmethyl)oxolane)dichloropalladium(II) Pd1 and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II)) Pd2, were screened for cytotoxic activity through in vitro study on the HCT-116 colorectal carcinoma cell line and on the MRC-5 healthy lung pleura cell line. Activity of complexes was assessed by comparing it to the cisplatin. The cells viability and proliferation were determined using MTT assay.

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