Mono- and Diamination of 4,6-Dichloropyrimidine, 2,6-Dichloropyrazine and 1,3-Dichloroisoquinoline with Adamantane-Containing Amines
Keyword(s):
N-heteroaryl substituted adamantane-containing amines are of substantial interest for their perspective antiviral and psychotherapeutic activities. Chlorine atom at alpha-position of N-heterocycles has been substituted by the amino group using convenient nucleophilic substitution reactions with a series of adamantylalkylamines. The prototropic equilibrium in these compounds was studied using NMR spectroscopy. The introduction of the second amino substituent in 4-amino-6-chloropyrimidine, 2-amino-chloropyrazine, and 1-amino-3-chloroisoquinoline was achieved using Pd(0) catalysis.
1991 ◽
Vol 64
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pp. 16-20
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1976 ◽
Vol 17
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pp. 201-202
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1975 ◽
Vol 40
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pp. 2037-2042
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2006 ◽
Vol 36
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pp. 1479-1484
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1995 ◽
Vol 60
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pp. 6592-6594
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