scholarly journals Immunomodulatory Effects of Green Tea Polyphenols

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3755
Author(s):  
Shuzhen Wang ◽  
Zhiliang Li ◽  
Yuting Ma ◽  
Yan Liu ◽  
Chi-Chen Lin ◽  
...  

Green tea and its bioactive components, especially polyphenols, possess many health-promoting and disease-preventing benefits, especially anti-inflammatory, antioxidant, anticancer, and metabolic modulation effects with multi-target modes of action. However, the effect of tea polyphenols on immune function has not been well studied. Moreover, the underlying cellular and molecular mechanisms mediating immunoregulation are not well understood. This review summarizes the recent studies on the immune-potentiating effects and corresponding mechanisms of tea polyphenols, especially the main components of (–)-epigallocatechin-3-gallate (EGCG) and (–)-epicatechin-3-gallate (ECG). In addition, the benefits towards immune-related diseases, such as autoimmune diseases, cutaneous-related immune diseases, and obesity-related immune diseases, have been discussed.

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 193 ◽  
Author(s):  
Yasuyoshi Miyata ◽  
Yohei Shida ◽  
Tomoaki Hakariya ◽  
Hideki Sakai

Prostate cancer is the most common cancer among men. Green tea consumption is reported to play an important role in the prevention of carcinogenesis in many types of malignancies, including prostate cancer; however, epidemiological studies show conflicting results regarding these anti-cancer effects. In recent years, in addition to prevention, many investigators have shown the efficacy and safety of green tea polyphenols and combination therapies with green tea extracts and anti-cancer agents in in vivo and in vitro studies. Furthermore, numerous studies have revealed the molecular mechanisms of the anti-cancer effects of green tea extracts. We believe that improved understanding of the detailed pathological roles at the molecular level is important to evaluate the prevention and treatment of prostate cancer. Therefore, in this review, we present current knowledge regarding the anti-cancer effects of green tea extracts in the prevention and treatment of prostate cancer, with a particular focus on the molecular mechanisms of action, such as influencing tumor growth, apoptosis, androgen receptor signaling, cell cycle, and various malignant behaviors. Finally, the future direction for the use of green tea extracts as treatment strategies in patients with prostate cancer is introduced.


2015 ◽  
Vol 57 (8) ◽  
pp. 1631-1637 ◽  
Author(s):  
Eunmiri Roh ◽  
Jong-Eun Kim ◽  
Jung Yeon Kwon ◽  
Jun Seong Park ◽  
Ann M. Bode ◽  
...  

2010 ◽  
Vol 13 (6) ◽  
pp. 665-674 ◽  
Author(s):  
Isabel Baeza ◽  
Nuria M. De Castro ◽  
Lorena Arranz ◽  
Mónica De la Fuente

2017 ◽  
Vol 1 ◽  
pp. s55
Author(s):  
Sarah Y Siu ◽  
Georgina M Ferzli ◽  
Neil Brody

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