scholarly journals Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing

Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1749 ◽  
Author(s):  
Mohsin Ali Badshah ◽  
Na Yoon Koh ◽  
Abdul Wasy Zia ◽  
Naseem Abbas ◽  
Zahra Zahra ◽  
...  

Metal-enhanced fluorescence (MEF) is a unique phenomenon of surface plasmons, where light interacts with the metallic nanostructures and produces electromagnetic fields to enhance the sensitivity of fluorescence-based detection. In particular, this enhancement in sensing capacity is of importance to many research areas, including medical diagnostics, forensic science, and biotechnology. The article covers the basic mechanism of MEF and recent developments in plasmonic nanostructures fabrication for efficient fluorescence signal enhancement that are critically reviewed. The implications of current fluorescence-based technologies for biosensors are summarized, which are in practice to detect different analytes relevant to food control, medical diagnostics, and forensic science. Furthermore, characteristics of existing fabrication methods have been compared on the basis of their resolution, design flexibility, and throughput. The future projections emphasize exploring the potential of non-conventional materials and hybrid fabrication techniques to further enhance the sensitivity of MEF-based biosensors.

2007 ◽  
Vol 111 (51) ◽  
pp. 18856-18863 ◽  
Author(s):  
Mustafa H. Chowdhury ◽  
Krishanu Ray ◽  
Kadir Aslan ◽  
Joseph R. Lakowicz ◽  
Chris D. Geddes

2003 ◽  
Vol 57 (5) ◽  
pp. 526-531 ◽  
Author(s):  
Chris D. Geddes ◽  
Alexandr Parfenov ◽  
Joseph R. Lakowicz

Chemically deposited silver particles are widely used for surface-enhanced Raman scattering (SERS) and more recently for surface-enhanced fluorescence (SEF), also known as metal-enhanced fluorescence (MEF). We now show that metallic silver deposited by laser illumination results in an ∼7-fold increased intensity of locally bound indocyanine green. The increased intensity is accompanied by a decreased lifetime and increased photostability. These results demonstrate the possibility of photolithographic preparation of surfaces for enhanced fluorescence in microfluidics, medical diagnostics, and other applications.


Author(s):  
Bong Jae Lee ◽  
Willard Hanson ◽  
Bumsoo Han

Metal-enhanced fluorescence has been extensively studied over the past three decades due to numerous opportunities for enhanced fluorescence sensing and imaging in microfluidics and medical diagnostics. Since the interaction between plasmonic nanoparticles and quantum dots (QDs) is the near-field phenomenon, most of past studies employed dielectric spacers to maintain the nanoscale interparticle distance. In the present study, however, we investigate the enhanced fluorescence from QDs that are mixed with plasmonic nanostructures, such as gold nanoshell (GNS), in the aquatic medium without confining inter-particle distances. Although the near-field interaction could not occur according to the distance estimation based on the particle concentrations, the experimental results indicate that the QD fluorescence can be greatly enhanced. A simple two-dimensional model based on Monte Carlo simulation reveals that there exist considerable probability that QDs reach the near-field region of GNSs due to the thermally induced Brownian motion. The results obtained from this study will facilitate the development of QD-mediated thermometry and ultimately enable image-guided deep-tissue thermal therapy.


2010 ◽  
Vol 107 (2) ◽  
pp. 024302 ◽  
Author(s):  
Yongxia Zhang ◽  
Anatoliy Dragan ◽  
Chris D. Geddes

Nanoscale ◽  
2021 ◽  
Author(s):  
Parinaz Fathi ◽  
Ayman Roslend ◽  
Kritika Mehta ◽  
Parikshit Moitra ◽  
Kai Zhang ◽  
...  

Increasing the fluorescence quantum yield of fluorophores is of great interest for in vitro and in vivo biomedical imaging applications. At the same time, photobleaching and photodegradation resulting from continuous...


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